Innovative Personal Monitoring Approaches to Characterize Ultrafine and Fine Particulate Matter and Respiratory Health Effects

创新的个人监测方法来表征超细颗粒物和细颗粒物以及呼吸系统健康影响

• 批准号: 9894543
• 负责人: Seung-Hyun Cho
• 金额: $ 28.65万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-19 至 2022-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9894543
• 关键词: Accelerometer; Address; Adolescent; Adverse effects; Affect; Air; Air Pollutants; Air Pollution; Alveolar; Area; Assessment tool; Asthma; Biometry; Caliber; Carbon Black; Child; Childhood Asthma; Clinical; Data; Data Collection; Data Set; Deposition; Dose; Ecological momentary assessment; Environment; Environmental Health; Epidemiology; Evaluation; Exposure to; Foundations; Future; Global Positioning System; Health; Health Policy; Impairment; Individual; Inhalation; Institutes; Intake; Intervention; Joints; Knowledge; Link; Location; Lung; Measurement; Measures; Metals; Methodology; Methods; Modeling; Monitor; Nitrogen Dioxide; Outcome; Ozone; Participant; Particulate Matter; Pattern; Persons; Physiological Processes; Play; Proxy; Reactive Oxygen Species; Research; Research Design; Respiratory physiology; Risk; Role; Site; Source; Surface; Technology; Time; Toxic effect; Toxicology; Translating; Ultrafine; Work; air monitoring; asthmatic; data infrastructure; epidemiology study; fine particles; improved; innovation; insight; mHealth; miniaturize; nanometer; novel; particle; particle exposure; pollutant; respiratory; respiratory health; response; sensor; spatiotemporal; theories; tool; toxicant; ultrafine particle; ventilation

PROJECT SUMMARY/ABSTRACT Evidence from experimental toxicology studies suggests that ultrafine particles (UFP) play a significant role in particulate matter (PM) respiratory toxicity because of their high potential to transport toxicants via a large number concentration and a large surface area per unit mass as compared with larger particles, including PM2.5. However, the theory that UFPs confer greater respiratory health risks than larger particles has not been validated in epidemiological settings. Experts identified the limitations of previous UFP studies, including the absence of data for concurrent exposures to other ambient pollutants, the error in characterizing exposure by using proxies such as fixed-site monitors or distance from roadways, and by exposure metrics used in those studies that did not provide information about how much PM would have been inhaled into the lungs. The proposed study intends to improve the method to assess UFPs exposures for respiratory health effect studies by addressing previous research gaps. The proposed Project Team's approach is to assess concurrent exposures to UFPs and other co-pollutants that can confound the UFP– lung function relationship for asthmatic adolescents, conduct a person-level assessment of spatio-temporal variability for each UFP and PM2.5, and apply inhaled PM doses that account for physiological process of PM intake and contact with the lungs to preliminarily determine the degree of lung function changes affected by UFP exposure from co-pollutants. We will apply novel exposure assessment approaches enabled by our innovative integration of wearable PM sensors, biometric sensors, and mobile data collection tool to produce high-quality exposure data sets that can delineate the effects of UFPs from other co-pollutants. This approach is essential because the traditional approach of using central fixed-site data or external exposure concentration data does not provide information about the amounts of contaminants that are inhaled by individuals, and it significantly underestimates the respiratory responses because of the exposures. This proposed effort will form the foundation of future work by informing of the study design and approaches to produce robust personal exposure data to multiple pollutants and by providing preliminary data regarding the distinct and joint effects of varying size fractions of PM and other pollutants on lung function by using innovative exposure metrics. Increased knowledge about the respiratory effects from UFPs will subsequently guide future environmental health policies, air pollution management strategies and control technologies, and interventions and clinical monitoring to reduce the burden of asthma.

项目摘要/摘要 实验毒理学研究的证据表明，Ultrafine颗粒（UFP）起着重要作用 在颗粒物（PM）呼吸毒性中，由于其通过大型运输有毒物质的潜力很高 与较大的颗粒相比，数量浓度和每单位质量较大的表面积 PM2.5。但是，UFP赋予比大颗粒更大的呼吸健康风险的理论尚未 在流行病学环境中得到了验证。专家确定了以前的UFP研究的局限性， 包括缺少与其他环境污染物并发暴露的数据，错误 通过使用固定站点监视器或距道路距离等代理以及通过 这些研究中使用的暴露指标未提供有关PM的信息 它们被内在到肺部。拟议的研究旨在改善评估UFP暴露的方法 通过解决以前的研究差距，用于呼吸健康效应研究。拟议的项目团队的 方法是评估可能混淆UFP – ufps和其他共污染物的并发暴露。 哮喘青少年的肺功能关系，进行人级评估时空评估 每个UFP和PM2.5的可变性，并应用合并的PM剂量，以说明PM的物理过程 摄入量并与肺部接触，以初步确定受肺功能变化的程度 来自共污染物的UFP暴露。我们将采用新颖的曝光评估方法 可穿戴PM传感器，生物识别传感器和移动数据收集工具的创新整合以生产 可以从其他共污染物中描述UFP的影响的高质量暴露数据集。这 方法是必不可少的，因为使用中央固定点数据或外部曝光的传统方法 集中数据未提供有关吸入的污染物量的信息 个体，并且由于暴露而大大低估了呼吸反应。这 拟议的努力将通过告知研究设计和方法来构成未来工作的基础 通过提供有关多种污染物的强大个人暴露数据，并通过提供有关 通过使用，不同大小的尺寸分数和其他污染物对肺功能的不同和关节作用。 创新的暴露指标。随后，对UFP的呼吸作用的知识增加将随后 指导未来的环境健康政策，空气污染管理策略和控制技术， 以及干预措施和临床监测以减少哮喘的灼伤。