VERITY: Value and Evidence in Rheumatology using bioInformaTics, and advanced analYtics

VERITY：使用生物信息学和高级分析学的风湿病学价值和证据

基本信息

批准号：
9768189
负责人：
Daniel Hal Solomon
金额：
$ 89.49万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-20 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9768189
关键词：
ARHGEF5 gene Accountability Address Adherence Adult Affect Algorithms Americas Area Arthritis Behavior Therapy Big Data Bioinformatics Biological Markers Biosensor Body Weight decreased Childhood Clinical Clinical Investigator Clinical Research Clinical Trials Design Communities Computerized Medical Record Country Data Data Collection Databases Development Disease Evolution Faculty Feeds Foundations Funding Future Generations Goals Grant Harvest Health Technology Hospitals Infrastructure International Intervention Knowledge Learning Longevity Lupus Measurable Mentors Methodology Methods Mission Modeling Musculoskeletal Diseases National Institute of Arthritis and Musculoskeletal and Skin Diseases Natural Language Processing Outcome Outcome Measure Participant Patient Care Patient-Focused Outcomes Patients Pharmaceutical Preparations Phenotype Physical activity Population Protocols documentation Psoriasis Psoriatic Arthritis Registries Research Research Design Research Methodology Research Personnel Resources Rheumatism Rheumatology Science Seeds Services Societies Supervision Technology Testing Training Woman Work analytical method behavioral economics bioinformatics resource care outcomes clinical care clinical research site cohort comparative effectiveness design distributed data effectiveness research feeding improved innovation insurance claims mHealth medical schools multidimensional data next generation novel optimal treatments patient engagement patient oriented prevent programs skills tool translational study treatment strategy

项目摘要

PROJECT ABSTRACT Pediatric and adult rheumatic and musculoskeletal (MSK) diseases challenge the clinical researcher: they affect the population across the lifespan, impact a broad range of patient-centered outcomes, are rarely cured, and often have multiple possible treatment strategies. If properly addressed, these factors present tremendous opportunities for improving patient care and outcomes of patients. The overarching goal of the Brigham and Women’s Hospital (BWH) CCCR is to facilitate advancements in the methodologic sciences supporting clinical research within the NIAMS pediatric and adult rheumatic and musculoskeletal (MSK) disease missions. VERITY is organized around central scientific themes that can be applied to multiple rheumatic and MSK diseases. The Cores address the following cross-cutting areas: 1) including patients in clinical trial design, outcome selection, result interpretation, and dissemination; 2) integrating behavioral economics to enhance benefits of known interventions, i.e., adherence to medications, engagement in physical activity and weight loss; 3) extracting maximum information content from big data; 4) using smart technologies (mobile health) to advance clinical research; and 5) disseminating knowledge and mentoring of local and national rheumatic and MSK disease clinical researchers through distributed learning models. These scientific themes will be approached through several Cores described in the following Specific Aims. 1. To strategically direct, supervise, and provide financial accountability to VERITY and to train a broad group of local and national investigators for patient-oriented clinical research in pediatric and adult rheumatic and MSK diseases. (Administrative Core) 2. To develop and implement state of the art methods in innovative trials and longitudinal comparative effectiveness studies for rheumatic and MSK disease research. (Methodology Core) 3. To support bioinformatic approaches to enhance utilization of large databases for phenotyping relevant patients, and implementing biomarker, electronic medical record, and comparative effectiveness analyses. (Bioinformatics Resource Core)

项目摘要儿科和成人风湿病和肌肉骨骼 (MSK) 疾病对临床研究人员提出了挑战：它们影响人口的整个生命周期，影响广泛的以患者为中心的结果，但很少治愈，并且通常有多种可能的治疗策略，如果处理得当，这些因素都会存在。改善患者护理和患者治疗结果的巨大机会。布莱根妇女医院 (BWH) CCCR 旨在促进方法科学的进步支持 NIAMS 儿童和成人风湿病和肌肉骨骼 (MSK) 内的临床研究疾病任务。 VERITY 围绕中心科学主题组织，可应用于多种风湿病和 MSK 疾病核心涉及以下交叉领域：1) 包括参与临床试验的患者。设计、结果选择、结果解释和传播；2）整合行为经济学增强已知干预措施的益处，即坚持药物治疗、参加体育活动和减肥；3）从大数据中提取最大的信息内容4）使用智能技术（移动）健康）以推进临床研究；5）传播知识并为地方和国家提供指导风湿病和 MSK 疾病临床研究人员通过分布式学习模型学习这些科学主题。将通过以下具体目标中描述的几个核心来实现： 1. 战略性地指导，监督 VERITY 并提供财务责任，并培训广泛的地方和国家团队儿童和成人风湿病和 MSK 疾病以患者为导向的临床研究的研究人员。（行政核心） 2. 在创新试验和试验中开发和实施最先进的方法风湿病和 MSK 疾病研究的比较纵向有效性研究（方法学核心）。 3. 支持生物信息学方法，以加强大型数据库的利用，以进行相关表型分析患者，并实施生物标志物、电子病历和比较有效性分析。（生物信息学资源核心）