VERITY: Value and Evidence in Rheumatology using bioInformaTics, and advanced analYtics

VERITY：使用生物信息学和高级分析学的风湿病学价值和证据

基本信息

批准号：
9768189
负责人：
Daniel Hal Solomon
金额：
$ 89.49万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-20 至 2022-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9768189
关键词：
ARHGEF5 gene Accountability Address Adherence Adult Affect Algorithms Americas Area Arthritis Behavior Therapy Big Data Bioinformatics Biological Markers Biosensor Body Weight decreased Childhood Clinical Clinical Investigator Clinical Research Clinical Trials Design Communities Computerized Medical Record Country Data Data Collection Databases Development Disease Evolution Faculty Feeds Foundations Funding Future Generations Goals Grant Harvest Health Technology Hospitals Infrastructure International Intervention Knowledge Learning Longevity Lupus Measurable Mentors Methodology Methods Mission Modeling Musculoskeletal Diseases National Institute of Arthritis and Musculoskeletal and Skin Diseases Natural Language Processing Outcome Outcome Measure Participant Patient Care Patient-Focused Outcomes Patients Pharmaceutical Preparations Phenotype Physical activity Population Protocols documentation Psoriasis Psoriatic Arthritis Registries Research Research Design Research Methodology Research Personnel Resources Rheumatism Rheumatology Science Seeds Services Societies Supervision Technology Testing Training Woman Work analytical method behavioral economics bioinformatics resource care outcomes clinical care clinical research site cohort comparative effectiveness design distributed data effectiveness research feeding improved innovation insurance claims mHealth medical schools multidimensional data next generation novel optimal treatments patient engagement patient oriented prevent programs skills tool translational study treatment strategy

项目摘要

PROJECT ABSTRACT Pediatric and adult rheumatic and musculoskeletal (MSK) diseases challenge the clinical researcher: they affect the population across the lifespan, impact a broad range of patient-centered outcomes, are rarely cured, and often have multiple possible treatment strategies. If properly addressed, these factors present tremendous opportunities for improving patient care and outcomes of patients. The overarching goal of the Brigham and Women’s Hospital (BWH) CCCR is to facilitate advancements in the methodologic sciences supporting clinical research within the NIAMS pediatric and adult rheumatic and musculoskeletal (MSK) disease missions. VERITY is organized around central scientific themes that can be applied to multiple rheumatic and MSK diseases. The Cores address the following cross-cutting areas: 1) including patients in clinical trial design, outcome selection, result interpretation, and dissemination; 2) integrating behavioral economics to enhance benefits of known interventions, i.e., adherence to medications, engagement in physical activity and weight loss; 3) extracting maximum information content from big data; 4) using smart technologies (mobile health) to advance clinical research; and 5) disseminating knowledge and mentoring of local and national rheumatic and MSK disease clinical researchers through distributed learning models. These scientific themes will be approached through several Cores described in the following Specific Aims. 1. To strategically direct, supervise, and provide financial accountability to VERITY and to train a broad group of local and national investigators for patient-oriented clinical research in pediatric and adult rheumatic and MSK diseases. (Administrative Core) 2. To develop and implement state of the art methods in innovative trials and longitudinal comparative effectiveness studies for rheumatic and MSK disease research. (Methodology Core) 3. To support bioinformatic approaches to enhance utilization of large databases for phenotyping relevant patients, and implementing biomarker, electronic medical record, and comparative effectiveness analyses. (Bioinformatics Resource Core)

项目摘要小儿和成人风湿和肌肉骨骼（MSK）疾病挑战临床研究人员：它们会影响整个寿命的人口，影响广泛的以患者为中心的结果，很少治愈，通常具有多种可能的治疗策略。如果正确解决，这些因素存在改善患者护理和患者结果的巨大机会。总体目标 Brigham and妇女医院（BWH）CCCR将促进方法论科学的进步在NIAMS小儿和成人风湿和肌肉骨骼（MSK）中支持临床研究（MSK）疾病任务。 Verity是围绕中心科学主题组织的，可以应用于多个风湿性和 MSK疾病。核心解决以下横切区域：1）包括患者参加临床试验设计，结果选择，结果解释和传播； 2）将行为经济学整合到提高已知干预措施的益处，即遵守药物，参与体育锻炼和减肥； 3）从大数据中提取最大信息内容； 4）使用智能技术（移动技术健康）来推进临床研究； 5）传播当地和国家的知识和心理风湿病和MSK疾病临床研究人员通过分布式学习模型。这些科学主题将通过以下特定目标中描述的几个核心接触。 1。在战略上指导，监督并向真实责任提供财务责任，并培训一群地方和国家针对儿科和成人风湿病和MSK疾病的患者临床研究的研究者。（行政核心）2。在创新试验中开发和实施艺术方法的状态风湿性和MSK疾病研究的纵向比较有效性研究。（方法核心） 3。支持生物信息学方法来增强大型数据库的利用相关的表型患者以及实施生物标志物，电子病历和比较有效性分析。（生物信息学资源核心）