Technology-supported sedentary behavior intervention to promote recovery from cancer surgery

技术支持的久坐行为干预促进癌症手术康复

• 批准号: 9766200
• 负责人: Carissa A Low
• 金额: $ 7.95万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-15 至 2022-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9766200
• 关键词: Activities of Daily Living; Address; Adherence; Adjuvant; Algorithms; Area; Behavior Therapy; Behavior assessment; Behavioral; Biological Markers; Cancer Patient; Cancer Survivor; Caring; Carissa; Cellular Phone; Clinical; Clinical Psychology; Colorectal Cancer; Colorectal Surgery; Complement; Complication; Control Groups; Curative Surgery; Data; Data Reporting; Doctor of Philosophy; Energy Metabolism; Ensure; Excision; Frequencies; Funding; Future; Goals; Health; Health Benefit; Hospitalization; Hospitals; Impairment; Inflammation; Inflammatory; Intervention; Intervention Trial; Knowledge; Light; Logistics; Malignant Neoplasms; Malignant neoplasm of abdomen; Measures; Mentors; Methodology; Methods; Monitor; Morbidity - disease rate; Operative Surgical Procedures; Outcome; Participant; Patient Schedules; Patients; Perioperative; Perioperative Care; Phase; Physical activity; Postoperative Period; Program Development; Psychoneuroimmunology; Quality of life; Randomized; Randomized Clinical Trials; Recovery; Reporting; Research; Research Personnel; Risk; Role; Scientist; Silver; Surgical Oncology; Symptoms; Techniques; Technology; Testing; Time; Training; Training Activity; Training Programs; Walking; Work; anticancer research; base; behavior change; biobehavior; cancer invasiveness; cancer surgery; cancer therapy; career development; comparison group; curative treatments; depressive symptoms; design; empowered; feasibility trial; field study; functional disability; hospital readmission; improved; improved outcome; innovation; innovative technologies; mHealth; metastatic colorectal; mobile computing; modifiable behavior; multidisciplinary; negative affect; new technology; oncology; patient population; peritoneal cancer; physical symptom; primary outcome; programs; prototype; psychological symptom; public health relevance; randomized trial; readmission rates; reduce symptoms; sedentary; sedentary lifestyle; skills; standard of care; surgery outcome; survivorship; user centered design; wearable device

Project Summary/Abstract This K07 proposal details a comprehensive career development program that will provide the applicant (Carissa Low, PhD) with the support, knowledge, and skills needed to become an independent behavioral scientist in cancer research. Building on her background in clinical psychology and psychoneuroimmunology, Dr. Low’s goals are to develop scalable behavioral interventions for patients undergoing potentially curative cancer surgery and to examine the effects of these behavioral interventions on clinical outcomes and biobehavioral mechanisms. To achieve these goals, the candidate and her mentors have designed a comprehensive program of training activities and mentored research in the following areas: 1) conceptual and methodological training in physical activity and sedentary behavior research; 2) technology- based behavioral assessment and intervention; and 3) clinical issues in surgical oncology. The proposed mentored research will use knowledge and skills acquired via the training plan to refine and test a novel technology-supported intervention to reduce sedentary behavior before and after cancer surgery. Capitalizing on emerging mobile technology, the intervention will integrate real-time wearable sensor and patient-reported data from the preoperative waiting period to 30 days post-hospital discharge to detect prolonged sedentary bouts and displace low- energy sedentary behavior with brief walking breaks. The frequency and duration of walking breaks will be personalized based on participants’ fluctuating symptom burden. After an initial study to field test and refine the algorithm and intervention, Dr. Low will conduct a randomized controlled feasibility trial of the technology-supported sedentary behavior intervention. Measures of feasibility will include retention, adherence, and patient-reported acceptability, and primary outcomes include objective activity levels, patient-reported depressive and physical symptoms and quality of life, circulating inflammatory biomarkers, and 30-day postoperative outcomes. The proposed research will provide pilot data for a R01 application to fund a fully powered randomized trial of the technology-supported sedentary behavior intervention. Although this initial study focuses on patients undergoing curative surgery for metastatic colorectal or peritoneal cancer, the proposed approach is likely to have broad applicability across other cancer patient populations facing similar challenges. The proposed multidisciplinary training and mentored research complement Dr. Low’s previous research and will facilitate her transition to an independent researcher and leader in mobile health and biobehavioral oncology research.

项目摘要/摘要 该K07提案详细介绍了一项全面的职业发展计划，将提供 申请人（Carissa Low，PhD），并具有所需的支持，知识和技能 癌症研究的独立行为科学家。在她的临床背景下建立 心理学和心理免疫学，Low博士的目标是发展可扩展的行为 对接受潜在治愈癌症手术的患者进行干预措施，并检查 这些行为干预对临床结果和生物行为机制的影响。到 实现这些目标，候选人和她的导师设计了一个全面的计划 培训活动并在以下领域进行了指导研究：1）概念和 体育锻炼和久坐行为研究的方法论培训； 2）技术 - 基于行为评估和干预； 3）手术肿瘤学的临床问题。这 拟议的修改研究将使用通过培训计划获得的知识和技能来 完善并测试一种新型技术支持的干预措施，以减少久坐行为 癌症手术后。利用新兴的移动技术，干预将 术前等待的集成实时可穿戴传感器和患者报告的数据 院后出院30天，以检测长期久坐的久坐不足并取代低 - 能源久坐的行为，短暂的步行休息。步行的频率和持续时间 休息时间将根据参与者的波动符号伯恩（Burnen）个性化。首先 研究和完善算法和干预的研究，Low博士将进行随机的 技术支持的久坐行为干预的可行性试验。 可行性措施将包括保留，依从性和患者报告的可接受性，以及 主要结果包括客观活动水平，患者报告的抑郁和身体 症状和生活质量，循环炎症生物标志物和术后30天 结果。拟议的研究将为R01应用提供试点数据，以完全资助 技术支持的久坐行为干预的动力随机试验。 尽管这项最初的研究重点是接受转移性治疗手术的患者 结直肠癌或腹膜癌，所提出的方法可能具有广泛的适用性 在其他癌症患者人群中，面临类似挑战。提议 多学科培训并修补了研究完成Low博士以前的研究和 将促进她向移动健康的独立研究人员和领导者的过渡以及 生物行为肿瘤学研究。

项目成果

A Real-Time Mobile Intervention to Reduce Sedentary Behavior Before and After Cancer Surgery: Usability and Feasibility Study.

• DOI: 10.2196/17292
• 发表时间: 2020-03-23
• 期刊: JMIR perioperative medicine
• 作者: Low CA;Danko M;Durica KC;Kunta AR;Mulukutla R;Ren Y;Bartlett DL;Bovbjerg DH;Dey AK;Jakicic JM
• 通讯作者: Jakicic JM

A Real-Time Mobile Intervention to Reduce Sedentary Behavior Before and After Cancer Surgery: Pilot Randomized Controlled Trial.

• DOI: 10.2196/41425
• 发表时间: 2023-01-12
• 期刊: JMIR perioperative medicine
• 作者: Low, Carissa A;Danko, Michaela;Durica, Krina C;Vega, Julio;Li, Meng;Kunta, Abhineeth Reddy;Mulukutla, Raghu;Ren, Yiyi;Sereika, Susan M;Bartlett, David L;Bovbjerg, Dana H;Dey, Anind K;Jakicic, John M
• 通讯作者: Jakicic, John M