EB 2019 Symposium: The Environment and Gene Expression, Role of the Epigenome

EB 2019 研讨会：环境与基因表达、表观基因组的作用

• 批准号: 9763048
• 负责人: Philip M Iannaccone
• 金额: $ 0.3万
• 依托单位: LURIE CHILDREN'S HOSPITAL OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-15 至 2020-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9763048
• 关键词: Adult; Affect; American; Area; Biological Models; Biology; Chemical Exposure; Chemicals; Chromatin; Collaborations; DNA; Data; Development; Disease; Endocrine disruption; Environment; Environmental Exposure; Epigenetic Process; Experimental Pathology; Exposure to; Fetal Development; Fostering; Gene Expression; Gene Expression Alteration; Gene Expression Regulation; Generations; Genes; Goals; Growth; Health; Hour; Human; Knowledge; Link; Metabolism; Molecular; Pathology; Phenotype; Population; Proteins; Public Health; Research; Role; Science; Scientist; Societies; Study models; Surveys; Time; Toxicant exposure; Work; adverse outcome; epigenetic regulation; epigenome; fetal; follow-up; gene interaction; human disease; interest; meetings; programs; success; symposium

Abstract The proposal describes a 3-hour Symposium consisting of five expert presenters and four short talks from trainees entitled The Environment and Gene Expression, Role of the Epigenome. The interaction of genes and the environment has been an important focus topic for some time. The goal of achieving a direct connection between given environmental exposures to given gene expression alterations and then to a given phenotype has been elusive however. Moreover, transgenerational effects of environmental damage are well documented but not completely understood. As information surrounding epigenetic regulation of gene expression grows it is logical to attempt to use environmental alteration of epigenetic control as a link between exposure and disease. In recent years this link has been empirically strengthened. Exploring the role of environmental alteration of the epigenome in human disease is the subject of the proposed symposium. The symposium has been approved by the Program Committee of the American Society of Experimental Pathology (ASIP) at the EB 2019 meeting in Orlando FL April 6-10, 2019. The specific aims of the meeting are to 1) establish a forum for the discussion of the latest data linking specific alterations from known environmental exposure in both population and model system studies in a setting that is well attended and interdisciplinary 2) inform scientists from a broad range of scientific interests about the molecular mechanisms of endocrine disruption and other toxic exposures by known chemical exposures and 3) foster the growth of collaborative activity of the most current areas of experimentation around the role of chromatin landscape in regulation of gene expression with the best of environmental exposure science. The symposium will be embedded in the Experimental Biology annual meeting that typically has more than 14,000 registrants and will be under the aegis of the ASIP.

抽象的 该提案描述了一个3小时的研讨会，由五个专家演示者组成 和四个题为环境和基因的学员的简短会谈 表达，表观基因组的作用。基因与 一段时间以来，环境一直是一个重要的重点主题。目标 在给定的环境暴露与给定的环境暴露之间达到直接联系 基因表达改变，然后进行给定表型是难以捉摸的 然而。此外，环境破坏的转世代作用很好 记录但尚未完全理解。作为周围的信息 基因表达的表观遗传调节生长是合乎逻辑的 表观遗传控制的环境改变是暴露与暴露之间的联系 疾病。近年来，这种联系得到了经验加强。探索 表观基因组在人类疾病中的环境改变的作用是 拟议研讨会的主题。研讨会已由 美国实验病理学会计划委员会（ASIP） 在2019年4月6日至10日在奥兰多FL举行的EB 2019会议上。 会议是1）建立一个论坛，以讨论最新数据链接 人群中已知的环境暴露和 模型系统研究在参加良好和跨学科的环境中2） 从广泛的科学兴趣中了解有关分子的科学家 内分泌破坏的机制和其他有毒暴露 化学暴露和3）促进最多的协作活动的增长 围绕染色质景观作用的实验领域 通过最好的环境暴露科学调节基因表达。 研讨会将嵌入实验生物学年度会议中 通常有14,000多名注册人，将在 ASIP。