Human Imaging Core

人体成像核心

• 批准号: 9764350
• 负责人: BRADLEY J. ERICKSON
• 金额: $ 27.16万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2020-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9764350
• 关键词: Affect; Algorithms; Area; Atrophic; Automation; Autosomal Dominant Polycystic Kidney; Big Data; Biological Markers; Blood; Classification; Clinical Data; Clinical Research; Clinical Trials; Cyst; Cystic kidney; Data; Detection; Development; Diagnosis; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Disease Progression; End stage renal failure; Faculty; Foundations; Funding; Grant; Growth and Development function; Health Insurance Portability and Accountability Act; Hour; Image; Image Analysis; Individual; Industry; International; Intracranial Aneurysm; Ischemia; Kidney; Kidney Calculi; Liver; Magnetic Resonance Elastography; Magnetic Resonance Imaging; Measurement; Measures; Methodology; Methods; Multi-Institutional Clinical Trial; Nephrons; Normal Range; Organ; Oxygen; Patients; Polycystic Kidney Diseases; Quality Control; Renal Blood Flow; Renal Tissue; Renal function; Research Personnel; Resources; Scanning; Secondary to; Services; Standardization; Surface; Techniques; Technology; Time; Tissues; Training; Translating; United States National Institutes of Health; X-Ray Computed Tomography; analytical method; base; blood flow measurement; blood oxygen level dependent; calcification; clinical practice; cost; design; elastography; genomic data; human imaging; imaging biomarker; imaging capabilities; imaging modality; imaging study; improved; kidney imaging; new technology; novel; outcome forecast; preservation; primary endpoint; protocol development; rapid detection; secondary endpoint; therapy outcome; tool; urinary tract obstruction

HUMAN IMAGING CORE SUMMARY/ABSTRACT The focus of the Human Imaging Core (Director: Dr. Bradley Erickson) is to provide critical human imaging capabilities to MTPC investigators and extended national and international faculty by making a variety of services available. These include imaging protocol development; image transfer, management and storage; volumetric and other quantitative analysis (cyst distribution, cyst parenchyma-surface area, Dual energy CT) and advanced MR imaging analysis (renal blood flow measurements, intracranial aneurysm detection, and MR elastography) of affected organs in ADPKD. During the past grant cycle to date, the Human Imaging Core has provided image analysis for six NIH, two PKD Foundation, five industry, and three Mayo funded clinical studies or trials. These include volumetric analysis of 2,669 CT and 2,434 MR scans of kidneys or livers, in addition to MR measurements of RBF and other image analyses in a smaller number of patients. The volumetric analysis alone has taken approximately 5,613 hours. The Human Imaging Core has also assisted in the design and management of MR images from Mayo patients with ADPKD participating in multicenter clinical trials (CRISP and HALT) and the protocol development for DIPAK 1 (a clinical trial of Lanreotide supported by the Dutch Kidney Foundation and IPSEN Pharmaceutica). In addition, six new core services that were developed during the prior period: automated kidney segmentation from stereology, image-based classification of patients, magnetic resonance elastography, dual energy CT to characterize renal stones, renal blood flow, cyst- parenchyma surface area, are now available to researchers. Furthermore, the Human Imaging Core actively develops new technologies to enhance the breadth of offerings or the value of the current services. Technologies under development include: novel imaging methods for characterizing PKD (magnetization transfer imaging, diffusion, and blood-oxygen level determination) and differentiating cysts and parenchymal tissues. In addition to providing the services, the core offers training in these techniques. The core has educated and trained a large number of individuals from across the world on the proper use of tools to measure TKV and has also shared some of our algorithms developed in the past grant cycle. For these reasons, we believe that the Human Imaging Core is a critical resource for the study of PKD, and is a unique strength of the current application, as no other PKD Center has such a core.

人成像核心摘要/抽象 人类成像核心的重点（导演：布拉德利·埃里克森（Bradley Erickson）博士）是提供关键的人类成像 MTPC调查人员的能力，并扩大了国家和国际教师 可用的服务。这些包括成像协议开发；图像传输，管理和存储； 体积和其他定量分析（囊肿分布，囊肿实质表面面积，双能CT） 和高级MR成像分析（肾脏血流测量，颅内动脉瘤检测和MR ADPKD中受影响器官的弹性。在迄今为止的过去赠款周期中，人类成像核心具有 提供了六个NIH，两个PKD基金会，五个行业和三项梅奥资助的临床研究的图像分析 或试验。其中包括对肾脏或肝脏的2,669 CT和2,434张MR扫描的体积分析 少数患者的RBF和其他图像分析的MR测量值。体积分析 一个人只花了大约5,613小时。人类成像核心也有助于设计和 参与多中心临床试验的蛋黄酱患者的MR图像的管理（Crisp） dipak 1的停顿和协议开发 肾脏基金会和Ipsen Pharmaceutica）。此外，在 前期：来自立体学的自动肾脏分割，基于图像的患者分类， 磁共振弹性图，双能CT表征肾结石，肾脏血流，囊肿 - 实质表面积，现在可供研究人员使用。此外，人类成像核心主动 开发新技术，以增强产品的广度或当前服务的价值。 正在开发的技术包括：用于表征PKD的新型成像方法（磁化 转移成像，扩散和血氧水平的测定）和区分囊肿和实质性 组织。除了提供服务外，核心还提供了这些技术的培训。核心有 受过教育并培训了来自世界各地的大量个人，以适当使用工具 测量TKV，还分享了我们在过去的赠款周期中开发的一些算法。为此 原因，我们认为人类成像核心是研究PKD的关键资源，并且是独特的 当前应用的强度，因为没有其他PKD中心具有这样的核心。