Columbia University Skin Disease Resource-Based Center (epiCURE)

哥伦比亚大学皮肤病资源中心 (epiCURE)

• 批准号: 9765045
• 负责人: DAVID RINSEY BICKERS
• 金额: $ 77.12万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9765045
• 关键词: Academic Medical Centers; Address; Adopted; Algorithms; Area; Awareness; Basic Science; Biology; Biomedical Research; Charge; Clinic; Clinical; Clinical Research; Clinical effectiveness; Collaborations; Communities; Core Facility; Country; Cutaneous; Dermatology; Development; Disease; Disease model; Elements; Environment; Feasibility Studies; Fostering; Future; Goals; Immunity; Institute of Medicine (U.S.); Institution; International; Investigation; Mission; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Nerve; New York; Pathologic; Patients; Phase; Pilot Projects; Pre-Clinical Model; Quality of life; Research; Research Personnel; Research Project Grants; Research Training; Resources; Scientist; Services; Skin; Stem cells; Strategic Planning; Structure; Training and Education; Translating; Translational Research; Universities; base; cellular imaging; community based participatory research; design; fundamental research; improved; innovation; metropolitan; multidisciplinary; pre-clinical; pre-clinical research; precision medicine; preclinical efficacy; programs; public health relevance; response; skin disorder; sound; success; translational medicine

 DESCRIPTION (provided by applicant): This application proposes the creation of a Skin Disease Resource-Based Core center at Columbia University (epiCURE). The epiCURE is designed to address critical roadblocks on the Continuum of Translational research as defined by the Institute of Medicine. The continuum defines three critical translational phases in biomedical research: basic science into pre-clinical efficacy into clinical effectiveness. The Cores of the epiCURE center have been strategically configured to address these critical phases in skin disease research, and provide a unique set of services and resources to facilitate advancement of the Research Community along the translational continuum pipeline that is driven by a Precision Medicine-based algorithm and is responsive to the NIAMS mission. The epiCURE Center, and the Institutional Commitment that accompanies it, can accomplish this goal by providing a uniquely effective service-based vehicle for investigator interactions that further education, training and research in cutaneous biology and skin disease. The configuration of the epiCURE represents a natural, logical progression built on the previous successes of our existing SDRC over the past 18 years, in bridging basic discoveries and translational research, and catalyzing their entry into the clinic. We have given very careful consideration to selecting the service and resource components of the epiCURE so that they bolster the existing research excellence at Columbia University and the broader Research Community, which is comprised of 37 investigators at Columbia University as well as 37 investigators at other 18 institutions in the New York metropolitan area and across the country. In addition to an Administrative Core and innovative Enrichment Program, the epiCURE is structured around three Service Cores that span a continuum of basic, pre-clinical and translational research: 1) Skin Stem Cell Imaging and Manipulation (SCIM); 2) Skin Immunity, Integrity and Disease Models (SIND); and 3) Translational and Precision Medicine Resources (TRAP). The overall goal of the epiCURE center is to break down barriers to translational research, and accelerate the progress of investigation in skin disease research to rapidly advance from basepairs to bedside.

 描述（由应用程序提供）：本申请提出了哥伦比亚大学（Epicure）的基于皮肤疾病的核心中心的创建。该Epicure旨在解决医学研究所所定义的转化研究连续体的关键障碍。连续体定义了生物医学研究中的三个关键翻译阶段：基础科学对临床有效性的临床前有效性。 Epicure Center的核心已在战略上配置为解决皮肤病研究中的这些关键阶段，并提供了一套独特的服务和资源，以促进研究社区沿翻译连续管道的发展，这是由基于精确医学的算法驱动的，并且对NIAMS的响应迅速。 Epicure Center以及涉及它的机构承诺，可以通过为研究人员的相互作用提供基于服务的独特的工具来实现这一目标，以进一步教育，培训和研究皮肤生物学和皮肤病。 Epicure的配置代表了过去18年中现有SDRC的先前成功建立的自然，逻辑上的进展，这是在弥合基本发现和翻译研究的过程中，并促进了他们进入诊所的进入。我们已经非常仔细地考虑了Epicure的服务和资源组成部分。因此，他们加强了哥伦比亚大学和更广泛的研究社区的现有研究卓越，由哥伦比亚大学的37名调查员以及纽约大都会地区和全国其他18个机构的37个调查员组成。除了行政核心和创新的富集计划外，该Epicure还围绕三个服务核心构建，这些服务核心跨越了基本的，临床前和翻译的研究：1）皮肤干细胞成像和操纵（SCIM）； 2）皮肤免疫，完整性和疾病模型（SIND）； 3）翻译和精密医学资源（陷阱）。 Epicure Center的总体目标是打破翻译研究的障碍，并加速皮肤病研究的研究进展，从而迅速从底层底部发展到床边。