Washington University Rheumatic DiseasesResearch Resource-based Center

华盛顿大学风湿病研究资源中心

• 批准号: 9764270
• 负责人: Deborah J Lenschow
• 金额: $ 77.29万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9764270
• 关键词: Address; Adopted; Area; Autoimmunity; Basic Science; Bioinformatics; CRISPR/Cas technology; Cell Line; Clinical; Clinical and Translational Science Awards; Cytometry; Databases; Discipline; Disease; Environment; Fostering; Genome engineering; Genomic medicine; Genomics; Goals; Health; Human; Imaging technology; Inflammation; Infrastructure; Institution; Knock-in Mouse; Knock-out; Laboratories; Mentors; Musculoskeletal; Pathogenesis; Patients; Regenerative Medicine; Research; Research Personnel; Resources; Rheumatism; Sampling; Secure; Services; System; Technology; Tissues; Training and Education; Translating; Translational Research; Translations; Universities; Washington; base; biobank; bioinformatics tool; biomarker discovery; cellular imaging; cost effective; data management; design; disease registry; genomic data; improved; induced pluripotent stem cell; innovation; innovative technologies; interest; member; model building; multidisciplinary; mutant; next generation; next generation sequencing; programs; repository; response; translational genomics; translational impact

OVERALL ABSTRACT The overarching Goal of the Washington University Rheumatic Diseases Research Resource-based Center (WU-RDRRC) is to advance research in rheumatic diseases by providing the infrastructure, resources and opportunities for multiple levels of inquiry and translating those discoveries into treatments for delivery to patients. The WU-RDRRC seeks to advance the health of patients with rheumatic disease by supporting enabling technology and promoting the basic and translational research interests of its members. These interests are organized around three major themes: (1) Basic mechanisms of inflammation and autoimmunity; (2) Translational genomics and biomarker discovery; and (3) Musculoskeletal and Regenerative Medicine. Our Central Hypothesis is that translational endeavors in rheumatic diseases research require a team approach performed in a vibrant environment supported by a cross-disciplinary team of experts and state-of- the-art services. Our Focus is to promote interactive approaches that will accelerate the pace of innovative discoveries and translate findings to improvements in treatments for patients with rheumatic diseases. To accomplish our goals we propose the following: 1) A Translational Research Core (TRC) that comprises separate but related services devoted to supporting translational research endeavors: i) an integrated rheumatic disease registry and biospecimen repository (Biobank) that can be searched through electronic biomedical data management systems to allow annotation, tracking and sharing of tissue and databases; ii) a Genomics & Bioinformatics Facility (GBF) powered by the most up-to-date Next-Generation Sequencing technologies and bioinformatics tools to enhance the secure use and analysis of human genomic data and iii) an ImmunoMonitoring Facility (IMF) that offers access to mass cytometry for analysis of human samples. 2) A Genome Engineering Core (GEC) that facilitates functional studies through the use of technological advances such as CRISPR/Cas9 to generate mutant cell lines and knockout/knock-in mice and induced Pluripotent Stem Cells (iPSCs); and 3) A Cellular Imaging Core (CIC) that provides state-of-the-art imaging technologies for building models of health and disease. The Administrative Core promotes collaborative and synergistic interactions in rheumatic diseases research across multiple disciplines and fosters the mentoring of new investigators interested in rheumatic disease-related research.

总体抽象 华盛顿大学风湿病基于研究资源的总体目标 中心（WU-RDRRC）是通过提供基础设施，资源来提高风湿性疾病的研究 以及多个询问的机会，并将这些发现转化为处理的治疗方法 患者。 WU-RDRRC试图通过支持风湿病患者的健康 启用技术并促进其成员的基本和转化研究兴趣。这些 兴趣围绕三个主要主题组织：（1）炎症和自身免疫的基本机制； （2）转化基因组学和生物标志物发现； （3）肌肉骨骼和再生医学。 我们的核心假设是，风湿性疾病研究中的转化努力需要团队 在充满活力的环境中执行的方法，由专家和最新的跨学科团队支持 艺术服务。我们的重点是促进互动方法，以加快创新速度 发现并将发现转化为风湿性疾病患者的治疗方法的改善。 为了实现我们的目标，我们提出以下建议：1）构成的转化研究核心（TRC） 独立但相关的服务致力于支持翻译研究努力：i）综合 风湿病注册中心和生物循环库（生物库）可以通过电子搜索 生物医学数据管理系统，允许组织和数据库的注释，跟踪和共享； ii）a 基因组学和生物信息学设施（GBF）由最新的下一代测序提供支持 技术和生物信息学工具可增强人类基因组数据的安全使用和分析） 一种免疫调节设施（IMF），可访问质量细胞仪以分析人类样品。 2）a 基因组工程核心（GEC）通过使用技术进步来促进功能研究 例如CRISPR/CAS9生成突变细胞系，敲除/敲门小鼠并引起多能茎 细胞（IPSC）; 3）提供最先进成像技术的蜂窝成像核心（CIC） 建立健康和疾病的模型。行政核心促进协作和协同作用 风湿性疾病的相互作用跨多个学科的研究，并促进了新的指导 对风湿病相关的研究感兴趣的研究者。