Nanoparticulate Coatings Enhance Ion Detection

纳米颗粒涂层增强离子检测

• 批准号: 8715209
• 负责人: Ernest Kjell Lewis
• 金额: $ 35.05万
• 依托单位: IONWERKS, INC.
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-25 至 2015-12-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8715209
• 关键词: Alloys; Biological; Caliber; Charge; Collaborations; Deposition; Detection; Electronics; Electrons; Employee Strikes; Fast Electron; Film; Fluorescence Microscopy; Future; Goals; Height; Helium; Housing; Individual; Ions; Kinetics; Mass Spectrum Analysis; Measures; Metals; Microscope; Microscopy; Molecular; Noble Gases; Penetration; Peptides; Performance; Photons; Physiologic pulse; Porosity; Probability; Radial; Relative (related person); Rice; Sales; Semiconductors; Solid; Solutions; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Structure; Surface; System; Techniques; Testing; Time; Transmission Electron Microscopy; Universities; Vacuum; base; detector; improved; instrument; ion mobility; mass spectrometer; nano; nanoparticulate; particle; photonics; public health relevance; research study; simulation

DESCRIPTION (provided by applicant): A new thin film approach to increasing the gain and sensitivity of current and future fast particle detectors is hypothesized. An increased ion induced secondary electron yield at the first surface of the detector while retaining high timing accuracy will make such detectors suitable replacement for MCP detectors in biological applications such as electron or ion microscopies and time of flight mass spectrometers. Moreover, the detector may be sensitive to the energy or momentum of the incoming ion. Such information could simplify MALDI or electrospray MS spectra containing highly charged molecular ions.

描述（由申请人提供）：假设有一种新的薄膜方法可以提高当前和未来快速粒子探测器的增益和灵敏度。离子诱导增加 探测器第一表面的二次电子产量，同时保持高定时精度，将使此类探测器适合替代生物应用中的 MCP 探测器，例如电子或离子显微镜和飞行时间质谱仪。此外，检测器可能对进入离子的能量或动量敏感。这些信息可以简化含有高电荷分子离子的 MALDI 或电喷雾 MS 谱。