Frontiers of Aging: From Molecules to Physiology

衰老前沿：从分子到生理学

• 批准号: 9762278
• 负责人: MARCIA HAIGIS
• 金额: $ 5万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-03-15 至 2020-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9762278
• 关键词: Academia; Aging; Animal Model; Area; Atmosphere; Biology of Aging; Career Choice; Cell Aging; Cells; Chromatin; Clinical; Data; Educational workshop; Epigenetic Process; Explosion; Faculty; Feedback; Fostering; Foundations; Funding; Future; Generations; Genomic Instability; Geriatrics; Gerontology; Goals; Government; Growth; Health; Hearing; Human; Image; Individual; Industry; Intervention; Invertebrates; Knowledge; Location; Maine; Medical; Mentors; Methods; Molecular; Organism; Participant; Pathway interactions; Physiological; Physiology; Postdoctoral Fellow; Prize; Process; Request for Applications; Research; Research Personnel; Rivers; Science; Scientist; Senior Scientist; Signal Transduction; Societies; Stem cells; Sum; Travel; Work; body system; career; career development; collaborative environment; detection of nutrient; frontier; graduate student; interdisciplinary collaboration; meetings; next generation; novel; posters; pre-doctoral; programs; proteostasis; psychologic; social; symposium; translational approach; translational scientist; translational study; unpublished works

This application requests funds to support the 2019 Gordon Research Conference (GRC) on the Biology of Aging, to be held at the Grand Sumit Hotel at Sudnday River (Newry, Maine, USA) on July 14-19, 2019, and the Gordon Research Seminar (GRS), which will be held at the same location on July 13-14, 2019, immediately prior to the GRC. This will be the fifteenth Biology of Aging meeting since its origin in 1962. While geriatrics and gerontology societies and their conferences have focused on the medical, social and psychological consequences of aging, in the most recent two decades there has been a explosion of knowledge on underlying mechanisms of the aging process. While the biology of aging is still a relatively new field, this GRC has become the premier forum for unpublished data presentation and discussions, resulting in a meeting where one can view exciting current science and also see the future directions of the field. This meeting is unique in its diversity, reflected in the theme of the 2019 conference: “Frontiers of Aging: From Molecules to Physiology”. Participating scientists will present basic studies in invertebrate model organisms, as well as studies in higher organisms. Appropriately, the talks and posters will reflect the diversity of the biology of aging by ranging from molecular studies to understanding how aging impacts numerous cellular and organ systems and organisms. We will also hear exciting work on interventions to modulate aging. Finally, this meeting will emphasize novel methods in imaging and single cell efforts, which will stimulate the field. To meet these goals, we have organized a diverse program with the following sessions: 1) conserved pathways, 2) translational studies of aging, 3) chromatin and epigenetics, 4) genomic instability, 5) metabolites and signaling, 6) proteostasis, 7) nutrient sensing, 8) stem cells and clonal dynamics, and 9) cellular senescence. The meeting will incorporate a panel discussion, mentoring lunch, and numerous networking opportunities. Our multifaceted approach to meet the objectives of this meeting include: i) A program rich in scientific diversity of topic and approach with the overarching theme “Frontiers of Aging: From Molecules To Physiology”; ii) An atmosphere to promote interdisciplinary collaborations and stimulate scientific exchange; iii) Mentoring opportunities to promote interactions between junior investigators and senior, established investigators; and iv) Support of individual diversity in participation.

该申请要求资金支持2019年戈登研究会议（GRC） 老化，将于2019年7月14日至19日在美国缅因州纽里的Sudnday River（美国纽里）举行 戈登研究研讨会（GRS）将于2019年7月13日至14日在同一地点举行 直接在GRC之前。自1962年起起源以来，这将是衰老会议的第15个生物学。 老年医学和老年学会及其会议的重点是医疗，社会和 衰老的心理后果，在最近的二十年中 关于衰老过程的基本机制的知识。虽然衰老的生物学仍然是一个相对新的 字段，此GRC已成为未发表的数据演示和讨论的主要论坛，从而导致 开会可以查看令人兴奋的当前科学，还可以看到该领域的未来方向。这 会议的多样性是独一无二的，反映在2019年会议的主题：“老化的边界：来自 生理学分子”。参与的科学家将在无脊椎动物模型生物中介绍基础研究， 以及对较高生物体的研究。适当地，谈判和海报将反映 通过分子研究到了解衰老如何影响众多细胞和 器官系统和生物。我们还将听到有关调节衰老的干预措施的激动人心的工作。最后，这个 会议将强调成像和单细胞工作中的新方法，这将刺激该领域。见面 这些目标，我们组织了一个多样化的计划，其中包括以下会议：1）构成途径，2） 衰老的翻译研究，3）染色质和表观遗传学，4）基因组不稳定性，5）代谢物和信号传导， 6）蛋白质，7）营养感应，8）干细胞和克隆动力学以及9）细胞感应。这 会议将结合小组讨论，心理午餐和众多网络机会。我们的 达到这次会议目标的多方面方法包括：i）一项丰富的科学多样性计划 主题和方法与总体主题“衰老的边界：从分子到生理学”； ii） 促进跨学科合作并刺激科学交流的气氛； iii）指导 促进初级调查员与高级研究人员之间互动的机会；和iv） 支持个人参与的多样性。