Molecular Pathology and Imaging Core

分子病理学和成像核心

• 批准号: 9762894
• 负责人: JONATHAN P KATZ
• 金额: $ 16.56万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9762894
• 关键词: Biomedical Research; Cells; Collaborations; Core Facility; Country; Development; Digestive System Disorders; Doctor of Medicine; Equipment; Exposure to; Floor; Fostering; Funding; Gastrointestinal tract structure; Histology; Human Resources; Image; Individual; Institution; Laboratories; Lasers; Lead; Leadership; Light; Liver; Liver diseases; Microscope; Microscopy; Modeling; Molecular; Neurobiology; Organ; Pancreas; Pancreatic Diseases; Pennsylvania; Process; Productivity; Program Research Project Grants; Reagent; Research; Research Personnel; Research Training; Resources; Services; Sleep; Slide; Specialist; Surveys; System; Techniques; Technology; Tissue Sample; Tissues; Training; U-Series Cooperative Agreements; Universities; circadian; cost effective; experience; imaging capabilities; laser capture microdissection; live cell imaging; medical schools; member; molecular pathology; new technology; next generation sequencing; pathology imaging; programs; ranpirnase; square foot

PROJECT SUMMARY (MOLECULAR PATHOLOGY & IMAGING CORE) The Molecular Pathology and Imaging Core (MPIC) is a unique entity at the University of Pennsylvania and provides tremendous service, resources, expertise, and efficiency for investigators of the Center for Molecular Studies in Digestive and Liver Diseases (CMSDLD). The MPIC has specific expertise in processing and analyses of all tissue types relevant to the CMSDLD and includes specialized microscopes, as well as other reagents and equipment essential for the research of CMSDLD investigators; no resource with similar expertise exists on the Penn campus or in nearby institutions. In addition, by providing cost-effective approaches, the MPIC is particular beneficial to Pilot and Feasibility awardees, who receive subsidies for MPIC services, and junior investigators/Associate Members, many of whom do not yet have independent funding. Established in 1995 as part of a Program Project grant, the MPIC expanded in 1997 to serve CMSDLD investigators and, since its inception, has been heavily utilized and extremely successful, serving as a model core facility for numerous other Centers and Program Projects at the University of Pennsylvania and throughout the country. The MPIC is a key component of the CMSDLD, providing essential, routine services as well as cutting edge technologies to CMSDLD investigators. Currently comprising more than 1,000 square feet on the 9th floor of BRBII/III, the MPIC is lead by an experienced Director and Technical Director and supported by a highly-trained staff. Moreover, working with other Cores and Centers, the MPIC expands the resources and services available to CMSDLD investigators, and since the last competitive renewal of this application, the MPIC has continued to incorporate and integrate new services and technologies. Additionally, the MPIC promotes new and exciting collaborations and research directions. Overall, the MPIC serves the CMSDLD by pursuing the following two interrelated Specific Aims: (1) To enhance the efficiency and productivity of CMSDLD members by providing specialized technical resources, services, and expertise in histology, pathology, and imaging of the digestive tract, liver, and pancreas; and (2) To integrate new technologies that advance research and discovery for studies of digestive, liver, and pancreatic diseases by both surveying and anticipating the needs of CMSDLD members. As such, the MPIC provides exceptional utility, quality, value, experience, service, and commitment to the CMSDLD.

项目摘要（分子病理和成像核心） 分子病理学和成像核心（MPIC）是宾夕法尼亚大学和 为分子中心的研究人员提供巨大的服务，资源，专业知识和效率 消化和肝病研究（CMSDLD）。 MPIC在处理和 对与CMSDLD相关的所有组织类型的分析，包括专门的显微镜以及其他 CMSDLD研究人员研究至关重要的试剂和设备；没有类似的资源 宾夕法尼亚州校园或附近机构中存在专业知识。此外，通过提供具有成本效益的 方法，MPIC特别有益于飞行员和可行性获奖者，他们获得了MPIC补贴 服务和初级调查人员/同学成员，其中许多人还没有独立资金。 MPIC成立于1995年作为计划项目赠款的一部分，于1997年扩展为CMSDLD服务 调查人员以及自成立以来，已被大量利用且非常成功，作为模型 宾夕法尼亚大学和 全国。 MPIC是CMSDLD的关键组成部分，提供了必不可少的常规服务 以及CMSDLD研究人员的尖端技术。目前包含1000多个平方 MPIC在Brbii/III 9楼的脚上由经验丰富的主管和技术总监和 受到训练有素的员工的支持。此外，与其他核心和中心合作，MPIC扩展了 CMSDLD调查人员可用的资源和服务，以及自上次竞争性更新以来 应用程序，MPIC继续合并并整合新的服务和技术。此外， MPIC促进了新的和令人兴奋的合作和研究方向。总体而言，MPIC为 CMSDLD通过追求以下两个相互关联的特定目的：（1）提高效率和 CMSDLD成员的生产力通过提供专业的技术资源，服务和专业知识 消化道，肝脏和胰腺的组织学，病理学和成像； （2）整合新的 通过研究和发现进行研究和发现的技术，用于研究消化，肝脏和胰腺疾病的研究 调查和预期CMSDLD成员的需求。因此，MPIC提供了例外 实用程序，质量，价值，经验，服务以及对CMSDLD的承诺。