Ultrahigh-Field MRI of Hip Joint Diseases Leading to Early Osteoarthritis

导致早期骨关节炎的髋关节疾病的超高场 MRI

• 批准号: 9761980
• 负责人: Casey Peter Johnson
• 金额: $ 12.99万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9761980
• 关键词: 3-Dimensional; Acute; Address; Arthroscopic Surgical Procedures; Basic Science; Bone necrosis; Brain Diseases; Capital; Cartilage; Child; Clinical; Clinical Management; Clinical Research; Clinical Treatment; Contralateral; Degenerative polyarthritis; Development; Diagnosis; Diagnostic; Disease; Disease Management; Disease Progression; Disease model; Doctor of Philosophy; Dysplasia; Early Diagnosis; Educational workshop; Environment; Fibrocartilages; Foundations; Future; Goals; Head; Hip Joint; Hip Osteoarthritis; Hip region structure; Histologic; Histology; Hour; Image; Imaging Device; Imaging Techniques; Imaging technology; Ischemia; Joints; Legg-Perthes Disease; Location; Magnetic Resonance; Magnetic Resonance Imaging; Maps; Marrow; Measures; Mentored Research Scientist Development Award; Mentors; Minnesota; Modeling; Monitor; Morphology; Musculoskeletal; Musculoskeletal Diseases; Musculoskeletal System; Noise; Operative Surgical Procedures; Orthopedic Surgery procedures; Outcome; Pathologic; Pathology; Patient Care; Patient imaging; Patients; Phase; RF coil; Radiology Specialty; Relaxation; Research; Resolution; Resources; Schedule; Sensitivity and Specificity; Signal Transduction; Site; Specimen; Structure; Techniques; Technology; Therapeutic; Thinness; Time; Tissues; Total Hip Replacement; Training; Translational Research; Treatment Efficacy; Universities; Validation; Vascular Diseases; Veterinary Medicine; arthropathies; bone; clinical care; clinical imaging; contrast imaging; disability; early onset; experience; healing; imaging modality; imaging system; improved; innovation; joint injury; magnetic field; musculoskeletal imaging; non-invasive imaging; pre-clinical; premature; prevent; programs; research study; skills; support network; symposium; time use; tool; transmission process

PROJECT SUMMARY: This K01 award will provide training and protected time for Dr. Casey P. Johnson, PhD, to develop an independent research program to address a critical need for new imaging solutions to improve the clinical management of developmental hip joint diseases that are precursors to osteoarthritis (OA). As there is no cure for OA and end treatment is total hip replacement, it is imperative to diagnose and treat early hip pathologies before irreversible damage occurs to prevent long-term disability and progression to OA. However, management of these diseases, which include (among others) Legg-Calve-Perthes disease (LCPD) and femoroacetabular impingement (FAI), is hindered by a lack of sensitive and high-spatial-resolution imaging tools to evaluate early, potentially treatable, bone and cartilage damage. To address this challenge, Dr. Johnson will develop and validate techniques to quantitatively assess hip damage using ultrahigh-field (UHF) (≥7 Tesla) magnetic resonance imaging (MRI), the technological future for high-spatial-resolution imaging of the musculoskeletal (MSK) system. Dr. Johnson has a strong background in the development of efficient, quantitative, and high-resolution MRI methods and their application to vascular and brain diseases, making him uniquely qualified to advance UHF MRI of multifactorial MSK diseases. During the K01 award’s five-year training period, Dr. Johnson will develop his expertise in MSK imaging research, enhance his professional skills, and establish a network of support within the MSK and MRI research fields. He will be mentored by and collaborate with experts in radiology, orthopaedic surgery, pathology, veterinary medicine, and UHF MRI and receive structured training through coursework, seminars, workshops, scientific conferences, and hands-on experiences. Dr. Johnson’s research will be embedded within the University of Minnesota’s Center for Magnetic Resonance Research, a world-renowned research environment for the development and application of UHF MRI technology. Two specific aims will provide training in: (i) preclinical imaging of specimens using a small-bore 9.4T MRI system with histological validation; and (ii) clinical imaging of patients using a whole-body 7T MRI system with surgical validation. Aim 1 will develop and histologically validate, in a piglet model of LCPD, techniques to quantitatively assess early ischemia-induced changes to femoral head marrow, cartilage, and bone. This will address a need to stage LCPD in children prior to femoral head fragmentation. Aim 2 will develop and arthroscopically validate, in patients with FAI, techniques to quantitatively assess cartilage and labral damage. This will address a need to determine the extent of damage to identify candidates for reparative arthroscopic surgery. UHF MRI development will focus on T2, T2*, and T1ρ mapping using both short and ultrashort echo-time sequences to quantify tissues with both slowly- (cartilage and marrow) and rapidly- (bone and labrum) decaying MRI signals. This research will provide Dr. Johnson with a strong foundation to advance imaging to improve long-term clinical outcomes for young patients with hip and other joint diseases.

项目摘要：该K01奖将为Casey P. Johnson博士提供培训和受保护的时间 博士，制定独立研究计划，以解决新成像解决方案的关键需求 改善发展为骨关节炎前体（OA）的髋关节疾病的临床管理。 由于无法治愈OA，终端治疗是完全髋关节置换的，因此必须诊断和治疗 在不可逆损害发生前的早期髋关节病理，以防止长期残疾和向OA发展。 但是，这些疾病的管理包括（包括）legg-calve-perthes疾病（LCPD） 缺乏敏感和高空间分辨率的成像，阻碍了股骨替代的撞击（FAI） 提早评估，可能治疗，骨骼和软骨损伤的工具。为了应对这一挑战，博士 约翰逊将开发和验证技术，以使用超高场（UHF）定量评估髋关节损伤 （≥7Tesla）磁共振成像（MRI），这是高空间分辨率成像的技术未来 肌肉骨骼（MSK）系统。约翰逊博士在高效的发展方面具有很强的背景 定量和高分辨率MRI方法及其在血管和脑疾病中的应用，使他 具有独特的资格来推进多因素MSK疾病的UHF MRI。在K01奖的五年期间 培训期，约翰逊博士将发展他的MSK成像研究专家，并增强他的专业人士 技能，并在MSK和MRI研究领域建立支持网络。他将被他考虑并 与放射学，骨科外科，病理学，兽医医学和UHF MRI的专家合作 通过课程，半手，讲习班，科学会议和动手接受结构化培训 经验。约翰逊博士的研究将嵌入明尼苏达大学的中心 磁共振研究，一个世界知名的研究环境，用于开发和应用 UHF MRI技术。两个具体的目标将提供：（i）使用A的标本的临床前成像 小孔9.4T MRI系统具有组织学验证； （ii）使用全身的患者的临床成像 具有手术验证的7T MRI系统。 AIM 1将在仔猪模型中发展和组织学验证 LCPD，定量评估股骨头骨髓的变化，软骨，软骨， 和骨头。这将解决在股骨头分裂之前在儿童中上演LCPD的必要性。 AIM 2意志 在有FAI患者中，开发和关节验证了定量评估软骨的技术和 唇损伤。这将解决确定损害范围以确定候选人的损害程度的需求 关节镜手术。 UHF MRI开发将重点介绍T2，T2*和T1ρ映射，并同时使用Short和 超时回声序列，以缓慢（软骨和骨髓）和快速（骨）量化组织 和Labrum）腐烂的MRI信号。这项研究将为约翰逊博士提供良好的基础 成像以改善髋关节和其他关节疾病的年轻患者的长期临床结局。