Exercise, cognition, and cannabis use in adolescents

青少年的锻炼、认知和大麻使用

基本信息

批准号：
9889803
负责人：
Ileana Pacheco-Colón
金额：
$ 3.61万
依托单位：
FLORIDA INTERNATIONAL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-05-01 至 2021-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9889803
关键词：
Abstinence Address Adolescence Adolescent Adolescent and Young Adult Adolescent marijuana use Adverse effects Age Alcohol consumption Alcohol or Other Drugs use Alcohols American Attention Back Brain Brain region Cannabis Child Cognition Cognitive Complex Coupled Data Data Analyses Decision Making Development Drug usage Exercise Fostering Functional Magnetic Resonance Imaging Future Goals Grant Health Individual Knowledge Laws Light Link Longitudinal Studies Mediating Mediation Mediator of activation protein Memory Memory impairment Methods Moderate Exercise National Research Service Awards Neurons Neuropsychology Outcome Parents Performance Population Prevalence Prevention Psychomotor Performance Reporting Research Personnel Risk Risk Factors Role Sampling Self Efficacy Short-Term Memory Signal Transduction Social support Sports Statistical Methods Substance Use Disorder Symptoms Task Performances Time Tobacco use Training Training Support addiction adolescent substance use base cigarette smoking cognitive development cognitive function computerized data processing coping early onset exercise intensity exercise intervention financial incentive improved marijuana use marijuana user neural correlate prevent protective factors recruit relating to nervous system sex skills stress reactivity young adult

项目摘要

Project Summary/Abstract Cannabis use is prevalent among adolescents and young adults. Despite knowledge about adverse effects, there are few efficacious prevention and treatment efforts aimed at cannabis use in this population. Exercise is one promising avenue for both which has received limited attention in this context. Exercise interventions have been linked to increased abstinence rates in the treatment of substance use disorders. Studies also suggest that the association between exercise and substance use may depend on factors such as substance and exercise type. Specifically, sports participation has been consistently linked to increased alcohol and decreased tobacco use, but its association with cannabis use is less understood and may be moderated by factors such as age, sex, and specific sport. The role of exercise-related cognitive improvements in influencing outcomes has not yet been examined. Considering loosening cannabis laws, lower perceived risk of cannabis use among adolescents, and the extent of neural changes taking place during adolescence, understanding the complex associations between exercise, cognition, and cannabis use is crucial in informing future prevention and treatment efforts aimed at this population. The proposed NRSA training grant will leverage data from two ongoing longitudinal studies (R01 DA033156, U01 DA041156) to examine associations between exercise, cognition, and cannabis use. Specifically, this proposal will examine decision making as a mediator of the association between exercise and cannabis use among adolescents over a 1-year period (Aim 1). It will also examine the moderating influence of exercise on the association between cannabis use and memory performance among adolescents over a 1-year period (Aim 2). Finally, this project will examine the neural underpinnings of the associations between exercise and cognition in a sample of preadolescent children by analyzing BOLD activation during fMRI monetary incentive delay and N-back tasks (Aim 3). Through a carefully crafted training plan, the PI will gain advanced understanding of the effects of addiction and exercise on brain and cognitive function (Training Goals 1 and 2), as well as the skills necessary to conduct advanced longitudinal and fMRI data analyses (Training Goals 3 and 4). This application will foster the development of PI Pacheco-Colón as an independent researcher focused on disentangling risk and protective factors from consequences of adolescent substance use, and longitudinally examining the impact of early substance use on adolescent brain and cognitive development.

项目摘要/摘要在青少年和年轻人中，大麻使用普遍存在。尽管有不良影响，但在该人群中旨在用于大麻的有效预防和治疗工作。运动是在这种情况下，这两者都承诺了两者的注意力。运动干预措施与增加药物使用障碍治疗的禁欲率有关。研究也表明运动与物质使用之间的关联可能取决于物质和诸如物质和运动类型。具体而言，体育参与一直与增加的酒精和扩展的烟草使用，但其与大麻使用的关联较少了解，并且可能由年龄，性别和特定运动等因素。与运动有关的认知改善的作用影响尚未检查结果。考虑放松大麻法，降低了大麻的风险在青少年中使用以及青少年期间的神经变化程度运动，认知和大麻使用之间的复杂关联对于告知未来的预防至关重要治疗工作旨在这一人群。拟议的NRSA培训赠款将利用两个正在进行的纵向研究（R01 DA033156，U01 DA041156）检查运动之间的关联认知和大麻使用。具体而言，该建议将研究决策作为调解人在1年期间，青少年的运动与大麻使用之间的关联（AIM 1）。它也会检查运动对大麻使用与记忆之间关联的调节影响青少年在1年期间的表现（AIM 2）。最后，该项目将检查中立锻炼和认知之间的关联的基础分析fMRI货币激励延迟和N后折线任务期间的大胆激活（AIM 3）。通过一个精心制作的培训计划，PI将获得对成瘾和锻炼影响的深入了解关于大脑和认知功能（训练目标1和2），以及进行高级的技能纵向和fMRI数据分析（培训目标3和4）。该应用程序将促进PI的发展 Pacheco-Colón作为一名独立研究人员，重点是消除风险和保护因素青少年物质使用的后果，并纵向研究早期使用物质对青少年的大脑和认知发展。