Modeling Effective Health Policies for Colorectal Cancer

为结直肠癌建立有效的健康政策模型

基本信息

批准号：
8727270
负责人：
KAREN M KUNTZ
金额：
$ 92.8万
依托单位：
SLOAN-KETTERING INST CAN RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-01 至 2016-02-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8727270
关键词：
Address Advisory Committees Age Biological Markers Cancer Control Cancer Etiology Cancer Model Cessation of life Characteristics Collaborations Colorectal Cancer Computed Tomographic Colonography DNA Data Disease Equilibrium Evaluation Fecal occult blood Feces Flexible fiberoptic sigmoidoscopy Funding Future Genomics Goals Guidelines Health Policy Incidence Individual Intervention Malignant Neoplasms Medicare Methods Modality Modeling National Cancer Institute Online Systems Past Trends Pathway interactions Policies Policy Maker Policy Making Preventive Primary Prevention Process Race Randomized Controlled Trials Recommendation Relative (related person)Research Risk Risk Factors Secondary Prevention Services Surveillance Modeling Testing United States Update Washington Work base cancer therapy colorectal cancer screening cost effectiveness experience health disparity improved innovation insight member models and simulation modifiable risk mortality new technology population based screening sex shift work tool treatment strategy trend tumor

项目摘要

DESCRIPTION (provided by applicant): Colorectal cancer (CRC) is still the second most common cause of cancer death in the United States, despite the availability of a range of interventions to reduce the burden of CRC. Microsimulation modeling can inform policy makers in prioritizing among these cancer-control interventions. The CISNET-CRC team includes three collaborative modeling groups, each with a state-of-the-art, population-based microsimulation model for CRC: MISCAN, SimCRC, and CRC-SPIN. These three modeling groups have collaborated for eight years and have delivered a substantial body of policy-oriented work. We propose to continue this collaboration, further developing our models and using them to identify optimal cancer-control policies and practices to reduce the burden of CRC. Our proposed work centers around three specific aims. In Aim 1 we extend our models to reflect the evolving understanding of the CRC disease processes and to incorporate new and updated screening modalities, allowing us to address new policy questions. Here we focus on new data on genomics, biomarkers, pathways, and the upcoming data from randomized controlled trials of flexible sigmoidoscopy screening. In Aim 2 we apply our updated models to inform health policy, including evaluation of interventions across the cancer-control spectrum. New technologies and more individually tailored screening and treatment strategies will be evaluated with a special focus on health disparities. In Aim 3 we disseminate results from our models to inform health policy, via methods that engage policy makers and encourage appropriate use of modeling in policy making and decision support. Here we envision innovation using open-access web-based model applications. We will begin with model extensions required for specific applications, with the balance of the work shifting heavily toward applications over the course of the funding period. Dissemination of our findings will occur throughout the funding period.

描述（由申请人提供）：尽管可以采取一系列干预措施来减轻结直肠癌（CRC）的负担，但结直肠癌（CRC）仍然是美国癌症死亡的第二大常见原因。微观模拟模型可以帮助政策制定者确定这些癌症控制干预措施的优先顺序。 CISNET-CRC 团队包括三个协作建模小组，每个小组都拥有最先进的基于人群的 CRC 微观模拟模型：MISCAN、SimCRC 和 CRC-SPIN。这三个建模小组已经合作了八年，并交付了大量以政策为导向的工作。我们建议继续这种合作，进一步开发我们的模型，并利用它们来确定最佳的癌症控制政策和实践，以减轻结直肠癌的负担。我们提出的工作围绕三个具体目标。在目标 1 中，我们扩展了我们的模型，以反映对 CRC 疾病过程不断发展的理解，并纳入新的和更新的筛查模式，使我们能够解决新的政策问题。在这里，我们重点关注基因组学、生物标志物、通路的新数据，以及来自灵活乙状结肠镜筛查的随机对照试验的即将到来的数据。在目标 2 中，我们应用更新的模型来为卫生政策提供信息，包括评估整个癌症控制范围的干预措施。将评估新技术和更个性化的筛查和治疗策略，并特别关注健康差异。在目标 3 中，我们通过让政策制定者参与并鼓励在政策制定和决策支持中适当使用模型的方法，传播模型的结果，为卫生政策提供信息。在这里，我们设想使用基于网络的开放模型应用程序进行创新。我们将从特定应用程序所需的模型扩展开始，在资助期间，工作的平衡将主要转向应用程序。我们的研究结果将在整个资助期间传播。

项目成果

期刊论文数量（17）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Optimal colorectal cancer screening in states' low-income, uninsured populations—the case of South Carolina.

针对各州低收入、无保险人群的最佳结直肠癌筛查——以南卡罗来纳州为例。

DOI：
发表时间：
2015-06
期刊：
影响因子：
3.4
作者：
van der Steen, Ale;Knudsen, Amy B;van Hees, Frank;Walter, Gailya P;Berger, Franklin G;Daguise, Virginie G;Kuntz, Karen M;Zauber, Ann G;van Ballegooijen, Marjolein;Lansdorp
通讯作者：
Lansdorp

Should colorectal cancer screening be considered in elderly persons without previous screening? A cost-effectiveness analysis.

未经筛查的老年人是否应该考虑进行结直肠癌筛查？

DOI：
发表时间：
2014-06-03
期刊：
影响因子：
39.2
作者：
van Hees, Frank;Habbema, J Dik F;Meester, Reinier G;Lansdorp;van Ballegooijen, Marjolein;Zauber, Ann G
通讯作者：
Zauber, Ann G

Validation of Models Used to Inform Colorectal Cancer Screening Guidelines: Accuracy and Implications.

用于告知结直肠癌筛查指南的模型的验证：准确性和意义。

DOI：
发表时间：
2016-07
期刊：
影响因子：
0
作者：
Rutter, Carolyn M;Knudsen, Amy B;Marsh, Tracey L;Doria;Johnson, Eric;Pabiniak, Chester;Kuntz, Karen M;van Ballegooijen, Marjolein;Zauber, Ann G;Lansdorp
通讯作者：
Lansdorp

Estimation of Benefits, Burden, and Harms of Colorectal Cancer Screening Strategies: Modeling Study for the US Preventive Services Task Force.

结直肠癌筛查策略的益处、负担和危害的估计：美国预防服务工作组的建模研究。

DOI：
10.1001/jama.2016.6828
发表时间：
2016-06-21
期刊：
JAMA
影响因子：
0
作者：
Knudsen AB;Zauber AG;Rutter CM;Naber SK;Doria-Rose VP;Pabiniak C;Johanson C;Fischer SE;Lansdorp-Vogelaar I;Kuntz KM
通讯作者：
Kuntz KM

The appropriateness of more intensive colonoscopy screening than recommended in Medicare beneficiaries: a modeling study.

对医疗保险受益人进行比建议更严格的结肠镜检查的适当性：一项模型研究。

DOI：
发表时间：
2014-10
期刊：
影响因子：
39
作者：
van Hees, Frank;Zauber, Ann G;Klabunde, Carrie N;Goede, S Luuk;Lansdorp;van Ballegooijen, Marjolein
通讯作者：
van Ballegooijen, Marjolein