National Clinical Trials Network Research at the University of Wisconsin

威斯康星大学国家临床试验网络研究

• 批准号: 9888349
• 负责人: Lisa M Barroilhet
• 金额: $ 55.93万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-03-06 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9888349
• 关键词: American College of Radiology Imaging Network; American College of Surgeons Oncology Group; Cancer Burden; Cancer Center; Cancer Patient; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Cooperative Group Program; Data; Development; Eastern Cooperative Oncology Group; Ensure; Faculty; Goals; Grant; Gynecologic Oncology; Gynecologic Oncology Group; Image; Imaging Techniques; Infrastructure; Leadership; Malignant Neoplasms; Medical Oncology; Mission; Modernization; NCI Center for Cancer Research; National Clinical Trials Network; Oncology; Phase; Phase II/III Clinical Trial; Population; Population Heterogeneity; Prevention; Principal Investigator; Protocols documentation; Radiation Oncology; Radiation Therapy Oncology Group; Research; Research Infrastructure; Research Personnel; Resources; Strategic Planning; Structure; Surgical Oncology; Therapeutic; Time; Translational Research; Underserved Population; Universities; University of Wisconsin Comprehensive Cancer Center; Wisconsin; cancer clinical trial; cancer education; cancer therapy; data management; design; experience; innovation; interdisciplinary approach; interest; multidisciplinary; next generation; novel; programs; treatment trial

Project Summary/Abstract The University of Wisconsin Carbone Cancer Center (UWCCC), its leadership, and its faculty are driven by a mission to defeat cancer through rapid application of groundbreaking research in cancer education, prevention and treatment. Embedded in the UWCCC's strategic plan are tactics for expanding a modern research platform inclusive of a comprehensive clinical research program with exemplary data management and clinical trial prioritization as well as scientific oversight and leadership. The UWCCC NCTN LAPs multi-disciplinary team remains an integral component of this strategic initiative and collaborates with key faculty to support innovative translational research for next generation clinical trials within the NCI's National Clinical Trials Network. Since 1974, UWCCC faculty have functioned as leaders in the development of the NCI cancer cooperative group program; first within ECOG and then with RTOG, ACOSOG and GOG in the early 2000s. As the NCI and its NCTN transitioned to a centralized infrastructure in 2014, the UWCCC designed a LAPS team of collaborative principal investigators by combining the existing broad scientific leadership from three of the primary cooperative groups (ECOG/ACRIN, NRG and ALLIANCE). This multi-disciplinary approach with leaders from Surgical, Medical, Radiation and Gynecologic Oncology, facilitated an innovative governance structure to provide leadership and oversight in prioritization of Phase II/III clinical trials, timely trial activation and robust accrual as well as the development of junior faculty interested in oncologic clinical research. In the four years since our last grant submission, the UWCCC LAPS team has provided support for the important genomically-directed clinical trials as well as those with a focus on advanced imaging, while strengthening our Cancer Center's infrastructure. This UG1 application seeks support for continuing the NCTN activities within the UWCCC. This partnership remains an important mechanism for providing a diverse population of cancer patients with novel treatment approaches, as well as a means for providing resources and support for existing and new leaders within the NCTN to bring innovative translational projects to Phase II/III clinical trials.

项目摘要/摘要 威斯康星大学碳纤维癌中心（UWCCC），其领导层及其教职员工由 通过在癌症教育，预防中快速应用开创性研究来击败癌症的使命 和治疗。嵌入UWCCC的战略计划中是扩展现代研究平台的策略 包括具有示例性数据管理和临床试验的全面临床研究计划 优先级以及科学监督和领导力。 UWCCC NCTN圈多学科团队 仍然是该战略倡议的组成部分，并与关键教师合作支持创新 NCI国家临床试验网络中的下一代临床试验的转化研究。 自1974年以来，UWCCC教师一直是NCI癌症合作组发展的领导者 程序;首先在ECOG中，然后在2000年代初与RTOG，ACOSOG和GOG一起使用。作为NCI及其 UWCCC于2014年过渡到集中式基础设施，设计了一个合作的圈子团队 首席研究人员结合了三个主要合作社现有的广泛科学领导 组（ECOG/ACRIN，NRG和Alliance）。这种多学科的方法与外科手术的领导者 医学，辐射和妇科肿瘤学，促进了一种创新的治理结构 第二阶段/III临床试验的优先级领导和监督，及时的试验激活和强大的应计为 以及对肿瘤学临床研究感兴趣的初级教师的发展。自上次以来的四年 UWCCC LAPS团队Grant提交，为重要的基因组指导的临床提供了支持 试验以及专注于高级成像的试验，同时加强了癌症中心的基础设施。 该UG1应用程序寻求支持在UWCCC中继续进行NCTN活动。这个合作伙伴关系 仍然是为癌症患者提供新型治疗的多样化人群的重要机制 方法，以及为现有和新领导者提供资源和支持的手段 NCTN将创新的转化项目带入II/III期临床试验。