NURTURE:Research Training and Mentoring Program for Career Development of Faculty at Makerere University College of Health Sciences

培养：麦克雷雷大学健康科学学院教师职业发展研究培训和指导计划

• 批准号: 9756488
• 负责人: Nelson K Sewankambo
• 金额: $ 79.9万
• 依托单位: MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-31 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9756488
• 关键词: AIDS/HIV problem; Address; Africa; Africa South of the Sahara; Area; Award; Communicable Diseases; Country; Cryptococcal Meningitis; Development; Environment; Epidemic; Faculty; Fellowship; Focus Groups; Fostering; Funding; Goals; Grant; Guidelines; HIV; HIV/TB; Health; Health Priorities; Health Sciences; Health Status; Health system; Human Resources; Incentives; Indigenous; Individual; Infection; Infrastructure; Institution; International; Intervention; Investments; Link; Malaria; Master' s Degree; Medical Education; Meningeal Tuberculosis; Mentors; Mentorship; Morbidity - disease rate; Play; Policies; Population; Productivity; Publications; Research; Research Personnel; Research Support; Research Training; Resources; Role; Scientist; Secure; Services; Stretching; Teacher Professional Development; Training; Training Programs; Tuberculosis; Uganda; Universities; Ursidae Family; Vision; antiretroviral therapy; burden of illness; career; career development; co-infection; college; doctoral student; faculty mentor; faculty research; innovation; mortality; programs

 DESCRIPTION (provided by applicant): Sub-Saharan Africa (SSA) bears 24% of the world's burden of disease, the lowest health worker to population ratio and has less than 1% of the global financial resources and 3% of the human resource needs. Globally 35 million people are living with HIV/AIDS, of whom 9.7 million are receiving antiretroviral therapy. HIV/AIDS and related illnesses remain major challenges to health in SSA, where 69% of the global HIV disease burden resides. HIV/AIDS Co-infections including tuberculosis and cryptococcal meningitis remain major causes of morbidity and mortality among HIV-infected individuals. In Uganda, 1.4 million people were estimated to be living with HIV and only 38% are receiving ART according to the 2013 WHO guidelines for ART initiation. The other infectious diseases that have challenged the continent for decades still remain while new ones emerge or old ones re-emerge. Non- communicable diseases (NCDs) are increasingly recognized as emerging epidemics that add an additional burden to our weak health systems already stretched by the ongoing HIV, tuberculosis, malaria and other infectious diseases. Indigenous institutions like Makerere University in Uganda need to play their role in identifying and finding sustainable and easily accessible interventions to the priority national and regional health challenges. Institutios including Makerere University grapple with the inadequate numbers of well-trained researchers particularly at the junior and mid-level. In the last 20-30 years Uganda has made significant advances and substantial contributions to research related to regionally relevant priority health challenges. Some of the research findings have contributed to national and global policies in the areas of HIV/AIDS, tuberculosis (TB) and malaria. Makerere University College of Health Sciences (MakCHS) has played a central role in building Uganda's research capacity. The five-year funding from the Medical Education Partnership (MEPI) grant and its two linked awards (grants # 5R24TW008886, # 5R24TW008861 and # 4R25N5080968) have led to a remarkable further increase in the proportion of publications that have Ugandans as first authors. This demonstrates that the environment is ready for additional investments for research capacity enhancements that will support Ugandan institutions to leapfrog to the next level of research productivity. MakCHS and 4 other Ugandan have trained and mentored 15 PhD students and 68 masters' degree trainees and also supported 29 non-degree mentored faculty research fellowships. There are, however still major gaps in the research capacity of our training institutions required to accelerate improvements in the country's health status. We propose a five year training and mentoring program for junior and mid-level faculty with a particular focus on the three interlinked themes of HIV/AIDS and its associated co-infections, other infectious diseases including malaria, and NCDs. The goal of this proposal is to develop a sustainable culture for supporting research training and mentoring for career development of upcoming faculty in an environment at MakCHS that fosters continuous development and retention of independent researchers. To achieve this goal our program has three specific aims: Aim 1: To provide targeted training and mentorship for individualized research capacity development of junior and mid-level faculty to become independent research leaders capable of addressing regionally relevant health challenges and influence policy and practice. Aim 2: To increase faculty retention by facilitating research career progression through strengthening existing and emerging research groups focusing on HIV/AIDS-related illness, other infectious diseases and NCDs. Aim 3: To facilitate continued development of a conducive research environment at MakCHS with institutional research policies, infrastructure, incentives and services that support researchers to become internationally competitive in conducting high quality research. The proposed capacity building program is to contribute towards the realization of our long term vision for MakCHS to be a leading and transformational institution for academic excellence and innovation in health sciences in Africa. At the end of this 5-year training program, our overarching objective is to solidify research groups of productive, independent scientists who can competitively excel in securing international funding, strengthen the research culture at Makerere and build the capacity to support its partner universities in Uganda. MakCHS is increasingly recognized as a research leader in the area of HIV and associated co-infections, other infections including malaria and the emerging non-communicable diseases.

 描述（由适用提供）：撒哈拉以南非洲（SSA）占世界疾病燃烧的24％，是卫生工作者与人口比率最低的疾病，不到全球财务资源的1％和3％的人力资源需求。全球3500万人患有艾滋病毒/艾滋病，其中970万人接受了抗逆转录病毒疗法。艾滋病毒/艾滋病和相关疾病仍然是SSA健康的主要挑战，其中有69％的全球艾滋病毒疾病伯宁所居住。艾滋病毒/艾滋病的共同感染，包括结核病和隐孢菌脑膜炎，仍然是艾滋病毒感染者发病和死亡的主要原因。在乌干达，据估计有140万人患有艾滋病毒，只有38％的人根据2013年WHO艺术倡议指南接受艺术。几十年来挑战非洲大陆的其他传染病仍然存在，而新的疾病则出现或重新出现。越来越多的疾病（NCD）被越来越多地被认为是新兴的发作，这些事件为我们的较弱的卫生系统增加了额外的燃烧，而疾病，结核病，疟疾和其他传染病已经延伸。像乌干达的Makerere University这样的土著机构需要在识别和寻找可持续且易于获得的干预措施方面对国家和地区健康挑战的干预措施发挥作用。研究所包括麦克雷雷大学（Makerere University）努力应对训练有素的研究人员不足，尤其是在初中和中级。在过去的20 - 30年中，乌干达为与区域相关优先级健康挑战相关的研究做出了重大进步和重大贡献。一些研究发现为艾滋病毒/艾滋病，结核病（TB）和疟疾地区的国家和全球政策做出了贡献。 Makerere大学健康科学学院（Makchs）在建立乌干达的研究能力方面发挥了核心作用。医学教育合作伙伴关系（MEPI）赠款的五年资金及其两个链接奖项（赠款＃5R24TW008886，＃5R24TW008861和＃4R25N5080968）已导致了乌干达人作为乌干达人的著作比例的进一步增长。这表明环境已准备好进行额外的投资，以增强研究能力，这将支持乌干达机构跨越更高的研究生产力。麦克奇（Makchs）和其他4个乌干达人已经培训并培训了15名博士学位学生和68位硕士学位的学员，还支持29名非学位的教职研究金。但是，我们的培训机构的研究能力有很大的差距，以加速该国健康状况的改善。我们为初中和中级教师提供了五年的培训和心理计划，特别关注三个相互联系的艾滋病毒/艾滋病主题及其相关的共同感染，包括疟疾和NCD在内的其他传染病。该提案的目的是开发一种可持续的文化，用于在Makchs的环境中支持研究培训和心理发展，以促进独立研究人员的持续发展和保留。为了实现这一目标，我们的计划具有三个特定的目标：目标1：为初级和中级教师的个性化研究能力发展提供有针对性的培训和心态，以成为能够应对地区相关的健康挑战并影响政策和实践的独立研究领导者。目标2：通过促进研究职业发展，通过加强关注与艾滋病毒/艾滋病相关疾病的现有和新兴研究小组，其他传染病和NCD来提高研究职业的进步。目的3：为了支持Makchs的持续开发，具有机构研究政策，基础设施，激励措施和服务，以支持研究人员在进行高质量研究方面具有国际竞争力。拟议的能力建设计划是为实现我们的长期愿景做出贡献，使Makchs成为非洲健康科学学术卓越和创新的领先和变革型机构。在这项为期5年的培训计划结束时，我们的总体目标是巩固生产性，独立科学家的研究小组，他们可以有能力地获得国际资金，增强Makerere的研究文化，并建立支持其在乌干达的合作伙伴大学的能力。 Makchs越来越多地被认为是HIV和相关联合感染领域的研究领导者，包括疟疾和新兴的非通信疾病在内的其他感染。

项目成果

Conducting an ongoing HIV clinical trial during the COVID-19 pandemic in Uganda: a qualitative study of research team and participants' experiences and lessons learnt.

• DOI: 10.1136/bmjopen-2021-048825
• 发表时间: 2021-04-21
• 期刊: BMJ open
• 影响因子: 2.9
• 作者: Muwanguzi PA;Kutyabami P;Osingada CP;Nasuuna EM;Kitutu FE;Ngabirano TD;Nankumbi J;Muhindo R;Kabiri L;Namutebi M;Nabunya R;Kiwanuka N;Sewankambo N
• 通讯作者: Sewankambo N

Soluble Programmed Death-Ligand 1 (sPD-L1) is Elevated in Aggressive Prostate Cancer Disease Among African Men.

• DOI: 10.1007/s40487-022-00184-6
• 发表时间: 2022-06
• 期刊: ONCOLOGY AND THERAPY
• 影响因子: 2.7
• 作者: Katongole, Paul;Sande, Obondo J;Reynolds, Steven J;Joloba, Moses;Kajumbula, Henry;Kalungi, Samuel;Ssebambulidde, Kenneth;Nakimuli, Cynthia;Atuheirwe, Maxine;Orem, Jackson;Niyonzima, Nixon
• 通讯作者: Niyonzima, Nixon

Molecular characterisation of second-line drug resistance among drug resistant tuberculosis patients tested in Uganda: a two and a half-year's review.

• DOI: 10.1186/s12879-022-07339-w
• 发表时间: 2022-04-11
• 期刊: BMC INFECTIOUS DISEASES
• 影响因子: 3.7
• 作者: Mujuni, Dennis;Kasemire, Dianah Linda;Ibanda, Ivan;Kabugo, Joel;Nsawotebba, Andrew;Phelan, Jody E.;Majwala, Robert Kaos;Tugumisirize, Didas;Nyombi, Abdunoor;Orena, Beatrice;Turyahabwe, Irene;Byabajungu, Henry;Nadunga, Diana;Musisi, Kenneth;Joloba, Moses Lutakoome;Ssengooba, Willy
• 通讯作者: Ssengooba, Willy

Evaluation of Xpert ® MTB/XDR test for susceptibility testing of Mycobacterium tuberculosis to first and second-line drugs in Uganda.

乌干达结核分枝杆菌对一线和二线药物药敏试验的 Xpert® MTB/XDR 试验评价。

• DOI: 10.1101/2023.04.03.23288099
• 发表时间: 2023
• 期刊: medRxiv : the preprint server for health sciences
• 作者: Katamba,Achilles;Ssengooba,Willy;Sserubiri,James;Semugenze,Derrick;William,KasuleGeorge;Abdunoor,Nyombi;Byaruhanga,Raymond;Turyahabwe,Stavia;Joloba,MosesL
• 通讯作者: Joloba,MosesL

Short report: knowledge and perceptions of health workers that strengthen adherence for paediatric and adolescent clients on the intensive adherence counselling program in Kampala, Uganda: a qualitative study.

• DOI: 10.4314/ahs.v21i1.5s
• 发表时间: 2021-05
• 期刊: African health sciences
• 影响因子: 1
• 作者: Nasuuna E;Kigozi J;Muganzi A;Sewankambo N;Nakanjako D
• 通讯作者: Nakanjako D