Southern New England Partnership In Stroke Research, Innovation and Treatment (SPIRIT)

新英格兰南部中风研究、创新和治疗合作伙伴关系 (SPIRIT)

基本信息

批准号：
9757834
负责人：
MARK Jay ALBERTS
金额：
$ 32.74万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-15 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9757834
关键词：
Academic Medical Centers Acute Adult Agreement American Heart Association Area Blood Vessels Cause of Death Characteristics Childhood Childhood stroke Clinical Clinical Management Clinical Research Clinical Trials Clinical Trials Design Clinical Trials Network Collaborations Communities Community Hospitals Computer software Computerized Medical Record Connecticut Continuity of Patient Care Critical Care Development Discipline Disease Education Emergency Department Physician Enrollment Faculty Funding Future Generations Geographic Locations Goals Healthcare Hospitals Human Subject Research Image Enhancement Infrastructure Institution Institutional Review Boards International Lead Leadership Massachusetts Medical Records Mentors Mission Modeling Modernization Monitor Multicenter Studies Multicenter Trials National Institute of Neurological Disorders and Stroke Neurologist Neurology Neurosurgeon New England Patients Pediatric Hospitals Persons Policies Population Preparation Prevention Principal Investigator Protocols documentation Quality Control Records Recovery Rehabilitation therapy Research Research Personnel Research Project Grants Resource Sharing Rhode Island Science Scientist Specialist Stroke Stroke prevention Structure Sum System Talents Teleconferences Training Training and Education Translational Research United States United States National Institutes of Health Universities Vision Work acute stroke base biomarker development care systems clinical biomarkers clinical care clinical implementation collaborative environment data management data sharing design disability ethnic diversity experience innovation medical schools meetings member multidisciplinary nervous system disorder next generation operation patient oriented research patient population programs racial and ethnic racial diversity recruit rural patients rural setting stroke clinical trials stroke patient stroke therapy stroke trials success tool urban setting

项目摘要

We propose the Southern New England Partnership In Stroke Research, Innovation and Treatment (SPIRIT), a StrokeNet Regional Coordinating Center (RCC) anchored by 3 leading institutions: Yale School of Medicine, the Warren Alpert School of Medicine at Brown University, and Hartford Hospital. Each Hub is a Comprehensive Stroke Center with 14 total Primary Stroke Centers. Yale is the 7th largest hospital in the United States, and in collaboration with Brown and Hartford Hospital, and their respective networks, SPIRIT captures a diverse geographic area that provides access to 5.7 million people, including most adult and pediatric stroke patients in Connecticut and Rhode Island. This robust patient volume (over 3500 total stroke patients in 2016), combined with an exceptionally strong collaborative and organizational framework, gives SPIRIT great potential for clinical trial implementation. Principal Investigators Dr. Kevin N. Sheth (Yale), Dr. Karen Furie (Brown), and Dr. Mark Alberts (Hartford Hospital) bring a complementary set of leadership and high-level clinical trials experience in stroke. Each leader brings well recognized expertise in international multicenter studies and implementation of stroke systems of care, as well as a track record of high quality stroke trial recruitment and retention. In various capacities, they have worked together for over 12 years, and each PI leads an enthusiastic cadre of faculty across disciplines, to create a highly collaborative environment focused on stroke research, multicenter trials, membership on Institutional Review Boards, clinical trial committees, and extensive mentoring in patient-oriented research. SPIRIT maintains strong connections to NIH funded CTSA networks and is further strengthened by the following characteristics: 1) A pool of talented investigators with nationally recognized clinical and translational research expertise in stroke; 2) Rich diversity (both ethnic/racial as well as urban/rural) of patients in Southern New England currently not captured by the existing StrokeNet network; 3) Active leadership and participation in stroke communities and stroke systems of care in the areas of statewide policy, continuity of care, American Heart Association collaborations and regional education; 4) Deep investigator and patient pools for all three areas of StrokeNet initiatives – prevention, acute treatment, and recovery; 5) Access to a range of specialized tools already harmonized across centers including a common electronic medical record system (EPIC) and RAPID software for acute stroke imaging, enhancing data sharing and collaboration; 6) Continuous commitment from all three institutions to the central IRB model and use of a Master Trial Agreement; 7) Rich science core with ongoing NIH funded stroke studies and multiple, active StrokeNet proposals currently under review; and 8) An education core designed to identify, support and accelerate the development of tomorrow's stroke investigators. The Yale, Brown, and Hartford stroke teams together – where the sum of the collaboration is even more exciting than each part – is poised to make significant contributions to enhance and further the mission of NINDS and StrokeNet to reduce the burden of neurological disease.

我们提议建立新英格兰南部中风研究、创新和治疗合作伙伴关系 (SPIRIT)， StrokeNet 区域协调中心 (RCC) 由 3 个领先机构支持：耶鲁大学医学院、布朗大学沃伦阿尔珀特医学院和哈特福德医院每个中心都是一个综合性中心。耶鲁中风中心共有 14 个初级中风中心，是美国第七大医院。 SPIRIT 与布朗医院和哈特福德医院及其各自的网络合作，捕捉到了多元化的信息为 570 万人提供服务的地理区域，其中包括大多数成人和儿童中风患者康涅狄格州和罗德岛州的患者数量庞大（2016 年中风患者总数超过 3500 人）。凭借异常强大的协作和组织框架，赋予 SPIRIT 临床应用的巨大潜力首席研究员 Kevin N. Sheth 博士（耶鲁大学）、Karen Furie 博士（布朗大学）和 Mark 博士 Alberts（哈特福德医院）在以下方面带来了一套互补的领导力和高水平临床试验经验每位领导者都带来了国际多中心研究和实施方面公认的专业知识。卒中护理系统，以及各种高质量卒中试验招募和保留的记录。他们已经合作了超过 12 年，每个 PI 都领导着一支充满热情的教职人员队伍跨学科，创建一个高度协作的环境，专注于中风研究、多中心试验、机构审查委员会、临床试验委员会的成员资格以及以患者为中心的广泛指导 SPIRIT 与 NIH 资助的 CTSA 网络保持着紧密的联系，并通过以下方式得到进一步加强：具有以下特点： 1）拥有一批具有国家认可的临床和临床研究能力的优秀研究者中风的转化研究专业知识；2) 患者的丰富多样性（民族/种族以及城市/农村）位于新英格兰南部，目前尚未被现有 StrokeNet 网络捕获 3) 积极领导；参与中风社区和中风护理系统在联邦政策、护理连续性、美国心脏协会合作和区域教育；4) 深入的研究人员和患者库； StrokeNet 举措的三个领域——预防、急性治疗和康复；5) 获得一系列信息；各个中心已经协调了专门的工具，包括通用的电子病历系统 (EPIC) 和 RAPID 软件用于急性中风成像，增强数据共享和协作 6) 连续性；所有三个机构对中央 IRB 模式的承诺以及主试验协议的使用 7) Rich 科学核心，正在进行 NIH 资助的中风研究，以及目前正在进行的多项活跃的 StrokeNet 提案审查；8) 旨在识别、支持和加速未来发展的教育核心耶鲁大学、布朗大学和哈特福德中风研究小组携手合作——这是合作的总和比每个部分都更令人兴奋 – 准备为增强和进一步发展做出重大贡献 NINDS 和 StrokeNet 的使命是减轻神经系统疾病的负担。