Sleep disturbance in spinal cord injury: Identifying symptoms and risk factors

脊髓损伤中的睡眠障碍：识别症状和危险因素

• 批准号: 8699937
• 负责人: Donald J. Fogelberg
• 金额: $ 11.76万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8699937
• 关键词: Activities of Daily Living; Address; Adult; Adverse effects; Affect; Anxiety; Area; Award; Biological Models; Biomedical Research; Bladder; Breathing; Burn injury; California; Characteristics; Chronic; Circadian Rhythm Sleep Disorders; Clinical; Clinical Protocols; Clinical Trials; Cognitive; Data; Decubitus ulcer; Development; Diagnostic; Disease; Doctor of Philosophy; Environment; Ethnography; Evaluation; Frequencies; Functional disorder; Funding; General Population; Goals; Grant; Health; Home environment; Housing; Incidence; Individual; International; Intervention; Interview; Intestines; Knowledge; Lead; Life; Measures; Medical; Melatonin; Mental Depression; Methods; Mission; Multiple Sclerosis; Nature; Neurologic; Neurorehabilitation; Neurosecretory Systems; Obesity; Occupational; Occupational Therapy; Outcomes Research; Pain; Pain management; Paralysed; Patient Care; Patient Self-Report; Pharmaceutical Preparations; Phase; Physical Medicine; Physical activity; Physiologic Thermoregulation; Physiological; Plant Roots; Polysomnography; Population; Positioning Attribute; Prevalence; Prevention; Process; Property; Psychometrics; Quality of life; Questionnaire Designs; Questionnaires; Randomized Controlled Trials; Rehabilitation Outcome; Rehabilitation therapy; Reporting; Research; Research Project Grants; Research Training; Respondent; Risk Factors; Role; Science; Secondary to; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Sleep disturbances; Sleeplessness; Source; Spinal cord injury; Structure; Surveys; Symptoms; Techniques; Testing; Training Programs; Translating; Translational Research; Traumatic Brain Injury; United States National Institutes of Health; Universities; Vasopressins; Washington; Weight Gain; Work; actigraphy; adverse outcome; base; career; chronic pain; clinically significant; dual diagnosis; evidence base; experience; high risk; improved; improved functioning; instrument; interest; medical schools; news; novel; population based; post-doctoral training; professor; programs; public health relevance; rehabilitation strategy; research clinical testing; response; routine care; satisfaction; screening; theories; tool

DESCRIPTION (provided by applicant): Candidate Dr. Donald Fogelberg is currently Assistant Professor in the Department of Rehabilitation Medicine at the University of Washington (UW). He completed his PhD and his post-doctoral training in the Division of Occupational Science and Occupational Therapy at the University of Southern California (USC). While at USC, he worked on several federally funded research grants, including 3 ethnographic studies and two randomized controlled trials. In his current position, he works with two NIDRR-funded research teams, the Traumatic Brain Injury (TBI) Model System and the SCI Model System, both housed in the UW Department of Rehabilitation Medicine. Dr. Fogelberg's research experience includes multiple phases of the translational research process: collecting and analyzing qualitative, descriptive data; translating these data into structured clinical protocols suitable for testing; and preparing for and implementing an RCT. He has been actively involved in research concerning spinal cord injury (SCI) rehabilitation since 2005. Dr. Fogelberg's main research interest is in sleep disturbance in the context of chronic neurological conditions. His long term career objectives are to examine the impact of sleep disturbance on rehabilitation outcomes; to translate this knowledge into novel evidence- based rehabilitation strategies; and to utilize rigorous clinical trials research to evaluate interventions for sleep disturbance in those with chronic neurological conditions. Currently, his research is focused on sleep disturbance in SCI, with a view to developing a better understanding of both the frequency of sleep problems in SCI and the relationship of sleep disturbances to co-morbid conditions that are common in SCI, and developing more effective means of detecting sleep disturbance in this population. Environment The University of Washington School of Medicine consistently ranks among the top Medical Schools in the nation in the U.S. News and World Report for its excellence in research, clinical training programs, and patient care. The School of Medicine is an international leader in biomedical research, receiving over $500 million in research funding annually. The Department of Rehabilitation Medicine at the University of Washington has had a strong commitment to research since its inception. Research, both basic and clinical, is a major component of the departmental mission. The Department is consistently ranked in the top two in NIH funding and the top three in overall research funding for all rehabilitation departments. The department has six federally funded centers, including Model Systems grants for Spinal Cord Injuries, Traumatic Brain Injuries, and Burns; a Research and Training Center Grant for Multiple Sclerosis; a Program Project in Chronic Pain Management; and a Center for Outcomes Research in Rehabilitation. Research I will conduct two studies during the course of this award. From month 7 to month 30, I will complete a sleep study with two main components, each addressing one of my specific aims. The first component will be a structured cognitive interview with individuals living with SCI. Cognitive interviewing is a theory-based interview technique which focusses on the cognitive processes used by questionnaire respondents in generating their responses to survey or questionnaire items. The purpose of these interviews is to identify sources of response errors and improve questionnaire design. Working with the same subjects, I will then gather objective data on key sleep parameters using both actigraphy (ACT) and in-home polysomnography (PSG). After completing the sleep study, I will conduct the second study, a survey of adults with SCI. This survey will yield data on the psychometric properties of the screening instrument; the frequency of symptoms indicating insomnia, circadian rhythm sleep disorders (CRSD), and sleep related breathing disorders (SRBD) and the relationship of sleep disturbances to commonly co-occurring disorders.

描述（由申请人提供）：候选人 Donald Fogelberg 博士目前是华盛顿大学 (UW) 康复医学系助理教授。他在南加州大学 (USC) 职业科学与职业治疗系完成了博士学位和博士后培训。在南加州大学期间，他参与了多项联邦政府资助的研究经费，包括 3 项人种学研究和两项随机对照试验。在目前的职位上，他与两个由 NIDRR 资助的研究团队合作，即创伤性脑损伤 (TBI) 模型系统和 SCI 模型系统，这两个团队均位于华盛顿大学康复医学系。 Fogelberg 博士的研究经验包括转化研究过程的多个阶段：收集和分析定性、描述性数据；将这些数据转化为适合测试的结构化临床方案；准备和实施随机对照试验。自 2005 年以来，他一直积极参与脊髓损伤 (SCI) 康复的研究。Fogelberg 博士的主要研究兴趣是慢性神经系统疾病背景下的睡眠障碍。他的长期职业目标是研究睡眠障碍对康复结果的影响；将这些知识转化为新颖的循证康复策略；并利用严格的临床试验研究来评估对慢性神经系统疾病患者睡眠障碍的干预措施。目前，他的研究重点是 SCI 中的睡眠障碍，旨在更好地了解 SCI 中睡眠问题的发生频率以及睡眠障碍与 SCI 中常见并发症的关系，并开发更有效的治疗方法。检测该人群睡眠障碍的方法。环境 华盛顿大学医学院因其在研究、临床培训项目和患者护理方面的卓越表现，在《美国新闻与世界报道》中始终位居全美顶尖医学院之列。医学院是生物医学研究领域的国际领先者，每年获得超过 5 亿美元的研究经费。华盛顿大学康复医学系自成立以来一直致力于研究。基础和临床研究是该部门使命的重要组成部分。该部门在 NIH 资助中始终名列前两名，在所有康复部门的总体研究经费中名列前三。该部门有六个联邦资助的中心，包括脊髓损伤、创伤性脑损伤和烧伤模型系统拨款中心；多发性硬化症研究和培训中心拨款；慢性疼痛管理项目；和康复结果研究中心。研究 在获得该奖项期间，我将进行两项研究。从第 7 个月到第 30 个月，我将完成一项睡眠研究，其中包括两个主要部分，每个部分都针对我的一个具体目标。第一部分是对 SCI 患者进行结构化认知访谈。认知访谈是一种基于理论的访谈技术，重点关注问卷受访者在生成对调查或问卷项目的回答时使用的认知过程。这些访谈的目的是确定回答错误的来源并改进问卷设计。然后，我将使用相同的受试者，使用体动记录仪 (ACT) 和家庭多导睡眠图 (PSG) 收集有关关键睡眠参数的客观数据。完成睡眠研究后，我将进行第二项研究，即对患有 SCI 的成年人进行调查。这项调查将产生有关筛查工具心理测量特性的数据；失眠、昼夜节律睡眠障碍 (CRSD) 和睡眠相关呼吸障碍 (SRBD) 症状的频率以及睡眠障碍与常见并发疾病的关系。