Shared Resource: Biosample Repository Facility

共享资源：生物样本储存库设施

基本信息

批准号：
9754605
负责人：
DENISE C CONNOLLY
金额：
$ 15.94万
依托单位：
RESEARCH INST OF FOX CHASE CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9754605
关键词：
Abbreviations Advisory Committees Basic Science Bioinformatics Biological Biological Markers Biological Models Biometry Blood Blood Cells Blood Donations Blood specimen Cancer Biology Cancer Center Cancer Center Support Grant Cancer Control Cell Culture Techniques Cell Separation Clinical Clinical Data Collaborations Collection Comprehensive Cancer Center Computer Assisted Consent Custom Detection Development Development Plans Diagnostic Doctor of Philosophy Drug or chemical Tissue Distribution Enzyme-Linked Immunosorbent Assay Epigenetic Process Ethics Family Cancer History Family member Farming environment Fox Chase Cancer Center Foxes Freezing Funding Future Genomics Goals Health Health system Histopathology Facility Hospital Personnel Human Immunoperoxidase Technics Individual Informed Consent Institutional Review Boards Interleukin-6 International Intervention Laboratory Animals Link Malignant - descriptor Malignant Neoplasms Medical Oncologist Molecular Normal tissue morphology Participant Pathologic Pathologist Pathology Patient Self-Report Patients Peer Review Population Study Procedures Process Recording of previous events Research Research Personnel Research Support Resource Sharing Resources Sampling Services Specimen Stains Supervision Surgeon Surgical Pathology Therapeutic Tissue Banks Tissue Microarray Tissue Sample Tissues Training Transgenic Mouse Facility Translational Research Universities University Hospitals Urine Work animal facility automated image analysis cancer prevention clinical database high throughput screening imaging facilities imaging system lifestyle factors liquid crystal polymer medical schools member molecular modeling patient oriented peripheral blood programs quantitative imaging repository research study volunteer

项目摘要

MODEL SYSTEMS SHARED RESOURCE: BIOSAMPLE REPOSITORY FACILITY (BRF) PROJECT SUMMARY/ABSTRACT Fox Chase Cancer Center (FCCC) established biospecimen banking activities in 1987 to coordinate the ethical collection, storage, annotation and distribution of tissue and peripheral blood samples to support translational research. This centralized shared resource operates under the supervision of Denise Connolly, PhD (MT) and is advised by an inter-programmatic Facility Advisory Committee (FAC). To enhance BRF services, the Center invested $369,770 for a PE Vectra Multispectral Quantitative Imaging System and a MesoScale Discovery chemiluminescent ELISA platform. The Biosample Repository Facility (BRF) has three major functions: 1) to identify participants, obtain informed consent, collect tissue, blood and/or urine specimens and obtain information on personal and family histories of cancer, clinical intervention and lifestyle factors for use in research; 2) to process and store human biospecimens obtained through investigator-initiated studies; and 3) to provide tissue-related analysis services including custom tissue microarray (TMA) construction, standard immunoperoxidase and fluorescent immunohistochemical detection and analysis of biomarker expression. Working in collaboration with pathologists, medical oncologists, surgeons and other hospital personnel, specifically trained BRF staff obtains subject informed consent, collects samples and assembles comprehensive clinical, pathological and personal/demographic information about each donor and the corresponding samples. As part of this banking process, the BRF staff provides: 1) diagnostic pathology support; 2) a comprehensive informed consent process for the appropriate collection of tissue, blood and other biospecimens for research; 3) a specialized biospecimen bank devoted to the collection and distribution of de- identified specimens to support research; 4) custom TMA construction; 5) immunohistochemical staining; 6) computer assisted tissue analysis services; and 7) extensive supporting data from the clinical record and self- reported health history of each participant. All specimens collected by and housed in the BRF are linked to comprehensive clinical databases supported by the Population Studies Facility (PSF). The BRF currently houses over 16,500 fresh-frozen tissue samples, over 47,000 blood samples, and has access to >100,000 surgical pathology cases. The annual accruals for new tissue and blood specimens are approximately 1,500 and 3,000, respectively. In 2014, the BRF served 31 FCCC investigators (24 peer-review funded) across all five Research Programs. Ninety (90%) percent of the BRF's 2014 use (by primary service line) was by peer-review funded Cancer Center members. Future plans involve the Center's commitment to construct a dedicated freezer farm that will provide sample storage capacity for the next ten years.

模型系统共享资源：生物样品存储库设施（BRF）项目摘要/摘要 Fox Chase Cancer Center（FCCC）于1987年建立了Biospecimen Banking活动，以协调道德组织和外周血样本的收集，存储，注释和分布以支持翻译研究。该集中的共享资源在Denise Connolly，PhD（MT）和由程序间设施咨询委员会（FAC）建议。为了增强BRF服务，该中心为PE Vectra多光谱定量成像系统和中尺度发现投资369,770美元化学发光ELISA平台。生物样品存储库设施（BRF）具有三个主要功能：1）确定参与者，获得知情同意，收集组织，血液和/或尿液标本并获得有关癌症的个人和家庭历史，临床干预和生活方式因素的信息研究; 2）处理和存储通过研究人员发起的研究获得的人类生物测量； 3）提供与组织相关的分析服务，包括定制组织微阵列（TMA）结构，标准免疫过氧化物酶和荧光免疫组织化学检测和生物标志物表达的分析。与病理学家，医学肿瘤学家，外科医生和其他医院人员合作，经过专门培训的BRF员工获得了知情同意，收集样本和集会有关每个捐赠者和的全面临床，病理和个人/人口统计信息相应的样品。作为此银行过程的一部分，BRF员工提供：1）诊断病理支持; 2）适当收集组织，血液和其他的全面知识同意过程研究生物测量； 3）专门用于收集和分配的专业生物循环银行确定了支持研究的标本； 4）定制TMA构造； 5）免疫组织化学染色； 6）计算机辅助组织分析服务； 7）来自临床记录和自我的广泛支持数据报告了每个参与者的健康历史。 BRF中收集和安置的所有标本都链接到人口研究机构（PSF）支持的全面临床数据库。 BRF当前房屋超过16,500个新鲜的组织样品，超过47,000个血液样本，可以使用> 100,000 外科病理病例。新组织和血液标本的年应计费约为1,500 和3,000。 2014年，BRF为31名FCCC调查人员（由24个同行评审资助）服务于所有人五个研究计划。 BRF 2014年使用（主要服务线）的90％（90％）是同行评审资助的癌症中心成员。未来的计划涉及中心建造一个的承诺专用的冰柜农场将在未来十年内提供样品存储容量。