ACTIVE Cognitive Training Trial: 20-Yr Follow-up of Functioning, Health, & Dementia

主动认知训练试验：20 年功能、健康、

• 批准号: 9754732
• 负责人: GEORGE W. REBOK
• 金额: $ 73.81万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9754732
• 关键词: Accounting; Acute; Address; Affect; Age; Age of Onset; Aging; Algorithms; Alzheimer' s Disease; Alzheimer' s disease related dementia; Ambulatory Care; Automobile Driving; Caring; Cause of Death; Cessation of life; Code; Cognition; Comorbidity; Data; Data Set; Dementia; Disease; Drug Prescriptions; Elderly; Event; Financial Hardship; Financial cost; Follow-Up Studies; Growth; Health; Health Care Costs; Health Care Visit; Health care facility; Healthcare; Home Care Services; Hospitalization; Impaired cognition; Incidence; Independent Living; Individual; Intervention; Life; Link; Maintenance; Medicaid; Medicaid eligibility; Medicare claim; Medicare/Medicaid; Memory; Mental Depression; Methods; Morbidity - disease rate; Outcome; Participant; Personal Satisfaction; Population; Prevention; Preventive care; Primary Health Care; Public Health; Public Policy; Randomized Clinical Trials; Records; Reporting; Resources; Sampling; Speed; Testing; Training; Visit; base; cognitive ability; cognitive benefits; cognitive training; combat; cost; daily functioning; depressive symptoms; disability; disability burden; evidence base; falls; follow-up; frailty; functional loss; health care service utilization; health service use; improved; indexing; innovation; instrumental activity of daily living; medical supply; mortality; novel; nursing home length of stay; physical conditioning; prevent; processing speed; randomized trial; therapy design; treatment effect; treatment group

Abstract The Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) study is the largest randomized clinical trial (N = 2802) to examine whether cognitive training enhanced both cognitive abilities and everyday functioning in normal older adults. Subjects trained on memory, reasoning, or processing speed performed significantly above controls at 5- and 10-year follow-ups. In addition, trained subjects reported less difficulty in performing IADL tasks at 10-year follow-up. Speed and reasoning training was associated with reduction in auto crashes and in driving cessation. Recent preliminary, but promising findings suggest an effect of training on incidence of Alzheimer's and related dementias. While these findings provide strong support for the benefits of cognitive training, the results focus on only short-term outcomes. This proposed 20-year follow-up would allow us to address questions highly relevant to health care and public policy that can only be addressed when the majority of the sample is deceased: Is training-related enhancement of cognition and everyday functioning associated with a long-term reduction in disability, loss of independence, and incident dementia in advanced old age and a reduction in associated financial costs? We propose to employ a wide range of linked data including: Medicare and Medicaid Claims, National Death Index, driving records, and credit reports. This study will assess the long-term impact and sustainability of the ACTIVE interventions on critical real life outcomes and related costs in advanced old age, including 1) Maintenance of independent functioning; 2) Physical health, disability, frailty, and mortality; 3) Incidence and duration of Alzheimer's and related dementias and depression.

抽象的 独立和重要老年人（活跃）研究的高级认知训练是最大的随机认知训练 临床试验（n = 2802）检查认知训练是否增强了认知能力和日常能力 在正常的老年人中起作用。接受记忆，推理或处理速度的受试者执行 在5年和10年的随访中显着高于对照。此外，训练有素的受试者报告的难度较小 在10年随访中执行IADL任务。速度和推理培训与减少有关 自动崩溃和驾驶停止。最近的初步但有希望的发现表明了培训的影响 关于阿尔茨海默氏症和相关痴呆症的发病率。尽管这些发现为利益提供了大力支持 在认知训练中，结果仅着眼于短期结局。该建议的20年随访将 允许我们解决与医疗保健和公共政策高度相关的问题，只有在 大多数样本已故：与训练相关的认知和日常功能是 与长期降低残疾，独立性丧失和晚期痴呆症有关 老年和相关财务成本的减少？我们建议采用广泛的链接数据 包括：医疗保险和医疗补助索赔，国家死亡指数，驾驶记录和信用报告。这项研究 将评估积极干预措施对关键现实生活结果的长期影响和可持续性 以及高级老年的相关费用，包括1）维护独立功能； 2）身体 健康，残疾，脆弱和死亡率； 3）阿尔茨海默氏症和相关痴呆症的发病率和持续时间 沮丧。