University of Virginia - icddr,b Research Unit for Women's and Children's Health Research

弗吉尼亚大学 - icddr,b 妇女和儿童健康研究单位

• 批准号: 9754231
• 负责人: William A Petri
• 金额: $ 65.17万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9754231
• 关键词: Address; Adoption; African; Asians; Bangladesh; Birth Weight; Cessation of life; Child; Child Development; Child Health; Chronic; Clinical; Clinical Protocols; Clinical Research; Clinical Trials; Clinical trial protocol document; Collaborations; Communicable Diseases; Communities; Complement; Coordination and Collaboration; Country; Data; Development; Developmental Delay Disorders; Diarrhea; Enteral; Environment; Facility Accesses; Failure; Functional disorder; Goals; Government; Grant; Health; Health Status; Human Genetics; Immunology; Impairment; Income; Infant Malnutrition; Infection; Inflammation; Institutes; International; Intervention; Knowledge; Lead; Leadership; Live Birth; Malnutrition; Maternal Mortality; Maternal and Child Health; Maternal-fetal medicine; Modeling; Mothers; Mucous Membrane; Neonatal; Neonatal Mortality; Neonatology; Neurocognitive; Observational Study; Oral; Parasitology; Positioning Attribute; Pregnancy; Pregnant Women; Principal Investigator; Public Health; Publications; Recording of previous events; Rehydration Solutions; Research; Research Peer Review; Research Personnel; Respiratory Tract Infections; Role; Rotavirus Vaccines; Rural; Rural Population; Scientist; Site; Sustainable Development; Testing; United Nations; Universities; Urban Population; Vaccines; Virginia; Weight Gain; Woman; Work; authority; base; community based care; dietary supplements; experience; global health; improved; infant nutrition; innovation; invention; laboratory facility; microbiome; molecular diagnostics; mortality; multidisciplinary; neurodevelopment; novel; nutrition; oral vaccine; pollutant; population health; prevent; vaccinology

Project Summary We propose that the University of Virginia (UVa) and icddr,b become a Research Unit (RU) within the Global Network for Women's and Children's Health Research. Significance: Mothers and children in Bangladesh and other low-mid income countries suffer disproportionately from maternal and infant malnutrition, neonatal mortality from diarrhea and respiratory infections, vaccine failure and impaired child development. The UVa-icddrb Research Unit (RU) will address these critical needs of women and young children by complementing the existing Network strengths with added scientific expertise in infectious diseases, neurocognitive development, human genetics, maternal-fetal medicine, immunology, and vaccinology. The RU will also provide extraordinary access to rural and urban populations for clinical trials. Investigators: The RU Principal Investigator (PI) William Petri and Senior Foreign Investigator (SFI) Rashidul Haque have for 25 years co-led multidisciplinary teams studying maternal-child, with over 100 co-publications and eight on-going clinical trials or observational studies. They are joined at icddr,b by a multidisciplinary team of F. Qadri (Immunology), K. Zaman (Vaccinology), F. Tofail (Child Development), M. Billah and S. El Arifeen (Maternal and Child Health), T. Ahmed (infant nutrition) and at UVa by C. Chisholm (ob/gyn) and R. Sinkin (neonatology). Innovation: The RU has a long history of innovative studies and expertise in maternal-child health, including the impact of infection and inflammation on child neurocognitive development, role of airborne pollutants on respiratory infection, function of gut damage in oral vaccine failure and malnutrition. Approach: The RU will work within the Network to promote innovative studies that have the potential to lead to actionable and sustainable improvement in maternal and child health through the partnership of the RU with the government of Bangladesh (manifest through the worldwide implementation of oral rehydration solution, discovered at icddr,b and adoption nationwide of the Matlab model of community based care). Environment: The RU has unparalleled multidisciplinary strength, laboratory facilities and access to urban and rural populations of mothers and children. The icddr,b is one of the foremost global health institutes in the developing world with over 200 active clinical trials/protocols. The UVa Division of Infectious Diseases and International Health is the largest research unit at UVa with over $20 million in annual grant support and over two dozen active clinical protocols. The quarter of a century UVa-icddrb collaboration and unique and complementary expertise promises to bring unparalleled strengths to the Network's goal of making sustainable improvements in maternal and child health.

项目摘要 我们建议弗吉尼亚大学（UVA）和ICDDR，B成为全球的研究部门（RU） 妇女和儿童健康研究网络。 意义：孟加拉国和其他低中收入国家的母亲和儿童遭受不成比例的 从母亲和婴儿营养不良，腹泻和呼吸道感染的新生儿死亡率，疫苗 失败和儿童发展受损。 UVA-ICDDRB研究部（RU）将满足这些关键需求 通过增添科学专业知识的现有网络优势，妇女和幼儿的妇女和幼儿 在传染病，神经认知发展，人类遗传学，母亲医学，免疫学，免疫学， 和疫苗学。 RU还将为临床试验提供非凡的访问农村和城市人口。 调查人员：RU首席研究员（PI）William Petri和外国高级研究员（SFI）Rashidul Haque拥有25年的共同领导的多学科团队，他们研究母亲，共有100多个共同出版物 以及八项正在进行的临床试验或观察性研究。他们由一个多学科团队加入ICDDR，B F. Qadri（免疫学），K。Zaman（疫苗学），F。Tofail（儿童发展），M。Billah和S. El Arifeen （母亲和儿童健康），T。Ahmed（婴儿营养）以及C. Chisholm（OB/Gyn）和R. Sinkin的UVA （新生儿学）。 创新：RU在孕产妇健康方面拥有创新研究和专业知识的悠久历史，包括 感染和炎症对儿童神经认知发展的影响，空中污染物对 呼吸道感染，口服疫苗衰竭和营养不良中肠道损伤的功能。 方法：RU将在网络内部工作，以促进有可能导致的创新研究 通过与RU与RU与与 孟加拉国政府（通过全球实施口服补液解决方案，明显 在ICDDR，B，B和MATLAB基于社区护理的MATLAB模型的采用中发现）。 环境：RU具有无与伦比的多学科力量，实验室设施和进入城市的通道 以及母亲和儿童的农村人口。 ICDDR，B是最重要的全球卫生研究所之一 具有200多种主动临床试验/方案的发展中国家。 UVA传染病分部 国际卫生是UVA最大的研究部门，拥有超过2000万美元的年度赠款支持和 超过二十多个主动临床方案。四分之一世纪的UVA-ICDDRB协作和独特的和 互补的专业知识有望为网络的目标带来无与伦比的优势 孕产妇健康的可持续改善。