Flu2Text: A Multi-Site Study assessing an Intervention for 2nd Dose of Influenza Vaccine

Flu2Text：一项评估第二剂流感疫苗干预措施的多中心研究

• 批准号: 9753327
• 负责人: Alexander Gabriel Fiks
• 金额: $ 55.71万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9753327
• 关键词: 8 year old; Academy; Address; Adolescent; Adult; Affect; Age; American; Asses; Cessation of life; Characteristics; Child; Child Care; Child Health; Childhood; Communities; Country; Discipline of obstetrics; Dominican; Dose; Effectiveness; Effectiveness of Interventions; Family; Goals; Health Communication; Health behavior; Healthcare; Hospitalization; Individual; Influenza; Influenza vaccination; Intervention; Knowledge; Language; Low Income Population; Low income; Measures; Medical; Methods; Modeling; Morbidity - disease rate; Outcome; Outpatients; Parents; Pediatric Research; Pediatrics; Population; Randomized; Randomized Controlled Trials; Research; Risk; Sampling; Seasons; Severities; Site; Text Messaging; Time; Translational Research; Vaccination; Vaccines; Visit; Work; age group; behavior change; compare effectiveness; cost; disadvantaged population; forgetting; health literacy; high risk; improved; influenza virus vaccine; mortality; pediatrician; practice setting; primary outcome; public health relevance; recruit; secondary outcome; success; treatment as usual

Problem: Influenza infection results in high morbidity and mortality. Young children are at particular risk for incomplete influenza vaccination because, depending on their previous vaccination status, many need 2 doses in a single season, as one dose does not confer adequate protection. Yet, only half of those who receive the first dose receive the second. Besides forgetting to remember to return for subsequent doses, receipt of 2 doses in a season can be affected by limited parental knowledge regarding influenza vaccination such as lack of understanding of the need for a second dose, as well as the importance of prompt receipt of that dose. Even among disadvantaged populations, 90% of adults in the U.S. have a cellphone. In a scalable, efficient manner, text messaging can provide vaccine reminders that can both remind families to return for a second dose as well as offer educational information that can promote influenza vaccine health-literacy by addressing common barriers that result in missing or delaying a second dose. Our research in one low-income, urban primarily Dominican community has demonstrated the efficacy of using text message reminders to increase receipt of 2nd dose of influenza vaccine compared to solely a written reminder (72.2% vs. 57.7%; p<0.01). While previous text message vaccine reminder studies have demonstrated success, they have been conducted locally and primarily with a low-income population. A study with national scope is therefore vital to understanding the effectiveness and optimal use of text message reminders to parents with varied backgrounds and whose children are cared for in diverse practice settings. To achieve this goal, the proposed study has 3 specific aims: AIM 1: To compare the effectiveness i n improving receipt of the second dose of influenza vaccine of personalized text message reminders embedded with educational information vs. usual care in a diverse pediatric population in need of two doses in a given season. AIM 2: To compare the effectiveness i n improving t h e timeliness of the second dose of influenza vaccine of personalized text message reminders embedded with educational information vs. usual care in a diverse pediatric population in need of two doses in a given season. AIM 3: To assess parental and child characteristics that modify text message effectiveness. Methods: In each of 2 seasons, 2000 parents of 6 months through 8 year-old children in need of two doses that season (4000 total) in 50 practices nationally who have received the 1st influenza vaccine dose that season will be randomized to receive either 1) text message reminders embedded with influenza vaccine health-literacy promoting information or 2) usual care. Parents will be recruited through the American Academy of Pediatrics national Pediatric Research in Office Settings (PROS) network. Outcomes: The primary outcome is receipt of two doses by the end of the season (April 30). A secondary outcome will be timeliness of second dose receipt. If successful, this project could support and inform a new paradigm in interactive health communication in a low cost, scalable manner that may be readily disseminated.

问题：流感感染会导致高发病率和死亡率。幼儿有特别的风险 不完整的流感疫苗接种是因为，根据其先前的疫苗接种状态，许多需要2剂 在一个季节中，一个剂量没有提供足够的保护。但是，只有一半的人 第一剂量获得第二剂。除了忘记记住返回以后的剂量之外，还收到2 一个季节中的剂量可能会受到有关流感疫苗接种（例如缺乏流感）知识的有限知识的影响 了解第二剂量的需求以及及时收到该剂量的重要性。 即使在处境不利的人群中，美国有90％的成年人都有手机。在可扩展的 有效的方式，文本消息传递可以提供疫苗提醒，这些提醒既可以提醒家庭回来 第二剂量以及提供可以通过 解决导致缺失或延迟第二剂量的常见障碍。我们在一个低收入中的研究， 城市主要是多米尼加社区，证明了使用文本消息提醒的功效 与完全的书面提醒相比，增加了第二剂量流感疫苗的收到（72.2％比57.7％； p <0.01）。虽然以前的短信疫苗提醒研究已经证明了成功，但它们一直是 在本地和主要是低收入人群进行的。因此，对国家范围的研究对于 了解对有多样的父母的短信提醒的有效性和最佳用途 背景且孩子在各种练习环境中受到照顾。为了实现这一目标，提议 研究具有3个特定目的：目标1：比较提高第二剂量的有效性 个性化短信的流感疫苗提醒嵌入了教育信息与通常 在给定季节，需要两种剂量的各种儿科人群的护理。目标2：比较 有效性，提高了个性化文本的第二剂量流感疫苗的及时性 邮件提醒嵌入了教育信息与常规护理中的小儿种群中 在给定季节需要两剂。目标3：评估修改文本的父母和儿童特征 消息有效性。方法：在两个季节中，每个6个月至8岁的孩子的父母 在全国接受第一个流感的50种实践中，需要两次剂量（总共4000剂） 疫苗剂量该季节将被随机接收1）嵌入的短信提醒 促进信息的流感疫苗健康文素或2）通常的护理。父母将通过 美国儿科学会国家儿科研究（PROS）网络。结果： 主要结果是在本赛季结束时（4月30日）收到两剂。次要结果将是 第二剂收据的及时性。如果成功，该项目可以支持并告知新的范式 以低成本，可扩展的方式进行交互式健康交流，可以很容易地传播。

项目成果

Text Message Reminders for the Second Dose of Influenza Vaccine for Children: An RCT.

• DOI: 10.1542/peds.2022-056967
• 发表时间: 2022-09-01
• 期刊: PEDIATRICS
• 影响因子: 8
• 作者: Stockwell, Melissa S.;Shone, Laura P.;Nekrasova, Ekaterina;Wynn, Chelsea;Torres, Alessandra;Griffith, Miranda;Shults, Justine;Unger, Rebecca;Ware, Leigh Ann;Kolff, Chelsea;Harris, Donna;Berrigan, Lindsay;Montague, Heather;Localio, A. Russell;Fiks, Alexander G.
• 通讯作者: Fiks, Alexander G.

Pediatric Practices' Perceptions of Text Message Communication with Families: An American Academy of Pediatrics (AAP), Pediatric Research in Office Settings (PROS) Study.

儿科实践对与家人进行短信沟通的看法：美国儿科学会 (AAP)，办公室环境中的儿科研究 (PROS) 研究。

• DOI: 10.1055/s-0043-1763270
• 发表时间: 2023
• 期刊: ACI open
• 作者: Nekrasova,Ekaterina;Fiks,AlexanderG;Wynn,Chelsea;Torres,Alessandra;Griffith,Miranda;Shone,LauraP;Localio,Russell;Shults,Justine;Unger,Rebecca;Ware,LeighAnn;Stockwell,MelissaS
• 通讯作者: Stockwell,MelissaS