Frontiers in Cancer Research

癌症研究前沿

• 批准号: 9753297
• 负责人: Jeanne Ting Chowning
• 金额: $ 26.93万
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9753297
• 关键词: Address; Bioethics; Biological; Biological Sciences; Biomedical Engineering; Biomedical Research; Bone Marrow Transplantation; CRISPR/Cas technology; Career Choice; Cessation of life; Clinical; Clinical Research; Clinical Trials; Communities; Companions; Development; Discipline; Disease; Education; Educational Curriculum; Educational process of instructing; Educational workshop; Engineering; Ethical Issues; Ethics; Fostering; Fred Hutchinson Cancer Research Center; Funding; Genetic Engineering; Goals; Health Resources; High School Student; Human; Immunotherapy; International; Knowledge; Laboratories; Learning; Malignant Neoplasms; Medical Research; Mentors; Modeling; Molecular and Cellular Biology; NCI Center for Cancer Research; National Institute of General Medical Sciences; Next Generation Science Standards; Plasmids; Program Development; Proteins; Randomized Controlled Trials; Research; Research Personnel; Resources; Role; School Teachers; Schools; Science; Scientist; Secondary Schools; Students; Teacher Professional Development; Training; Translating; Underrepresented Students; Underserved Population; United States National Institutes of Health; Viola; Visit; Washington; Work; Youth; anti-cancer; anticancer research; cancer immunotherapy; cancer therapy; career; curriculum development; design; experience; follow-up; frontier; gene therapy clinical trial; interest; learning materials; lens; novel strategies; outreach program; pedagogy; precision genetics; programs; science education; science teacher; skills; social; student training; teacher

PROJECT SUMMARY/ABSTRACT Frontiers in Cancer Research (“Frontiers”) is presented by the Science Education Partnership (SEP) at Fred Hutchinson Cancer Research Center (“Fred Hutch”). The Frontiers program is designed to meet two goals of the National Institutes of Health (NIH) and National Institute of General Medical Sciences (NIGMS): to increase the STEM content knowledge and pedagogical skills of teachers and to engage students, especially those from underserved populations, in basic and clinical medical research. Overall, Frontiers aims to increase public understanding of basic molecular and cellular biology, how this knowledge informs research questions, and how clinical research translates into cancer therapies and cures. More specifically, Frontiers focuses on exciting new NIH-funded research at Fred Hutch, such as immunotherapy, that promises to fundamentally change cancer treatment. The program will also explore the ethical implications of cancer research-related topics. Another goal is to introduce students, particularly those from backgrounds underrepresented in the biomedical sciences, to career possibilities in research. 1) Frontiers will engage secondary school students in basic molecular/cellular biology and cutting-edge cancer research by creating, piloting, and disseminating two Next Generation Science Standards (NGSS)-aligned cancer-focused curricular units (Project Violet: Anti-Cancer Molecules, Cancer Immunotherapy) and three different types of hands-on scientific kits (Protein Modeling and Cancer Treatment, Bioengineering Plasmid Design, and CRISPR/Cas9). The units, which will consist of 5-7 lessons to span 2-3 weeks, will also help students examine ethical issues related to genetic engineering, gene therapy, and clinical trials. We will use small randomized controlled trials to evaluate the efficacy of the developed curricular materials. 2) Frontiers will enhance the ability of secondary school life science teachers to teach fundamental biological principles and practices through the lens of cancer research by providing 20 teachers annually (Y2-Y5) with a 3-week summer professional development program that includes a mentored research experience, and 7 day- long sessions throughout the school year. 3) Frontiers aims to inspire secondary school students from underrepresented communities to pursue biomedical and clinical research careers. Our introductory school-year outreach program will bring 270 students annually to Fred Hutch to meet scientists and participate in Frontiers lessons held in dedicated Fred Hutch student training labs. We will also create and implement a model for scientists at Fred Hutch to visit classrooms to assist teachers with lessons and share their career paths with students.

项目摘要/摘要 癌症研究的前沿（“边境”）由弗雷德的科学教育合作伙伴关系（SEP）提出 哈钦森癌症研究中心（“ Fred Hutch”）。边境计划旨在满足两个目标 美国国家卫生研究院（NIH）和国家一般医学科学研究所（NIGMS）：增加 STEM内容知识和教师的教学技能和吸引学生，尤其是来自 在基础和临床医学研究中服务不足的人群。总体而言，边境旨在增加公众 了解基本分子和细胞生物学，这些知识信息研究如何提出质疑以及 临床研究如何转化为癌症疗法和治疗方法。更具体地说，边境专注于 在弗雷德·哈奇（Fred Hutch）（例如免疫疗法）上令人兴奋的新NIH资助的新研究有望从根本上 改变癌症治疗。该计划还将探讨与癌症研究相关的道德意义 主题。另一个目标是介绍学生，尤其是来自背景的学生 生物医学科学，研究研究的可能性。 1）边界将与中学生与基本分子/细胞生物学和尖端癌症。 通过创建，驾驶和传播两个与一致的下一代科学标准（NGSS）进行研究 以癌症为中心的课程单元（紫罗兰色项目：抗癌分子，癌症免疫疗法）和三个 不同类型的动手科学试剂盒（蛋白质建模和癌症治疗，生物工程质粒 设计和CRISPR/CAS9）。这些单位将由5-7次跨越2-3周的课程组成，也将有助于 学生检查与基因工程，基因治疗和临床试验有关的道德问题。我们将使用 小型随机对照试验评估已发达的课程材料的效率。 2）边界将增强中学生活科学教师教基本生物学的能力 通过每年为20名教师（Y2-Y5）提供了通过癌症研究的原则和实践 3周的夏季专业发展计划，其中包括指导的研究经验和7天 - 整个学年的漫长会议。 3）边境旨在激发来自代表性不足社区的中学生购买 生物医学和临床研究职业。我们的介绍学年外展计划将带来270 每年的学生去弗雷德·哈奇（Fred Hutch）会见科学家，并参加敬业的弗雷德（Fred）的边界课程 赫奇学生培训实验室。我们还将为弗雷德·哈奇（Fred Hutch）的科学家创建并实施一个模型 教室为教师提供课程，并与学生分享他们的职业道路。