UAB Institutional Career Development Program in HIV-Related Heart, Lung, Blood and Research

UAB 艾滋病毒相关心脏、肺、血液和研究机构职业发展计划

• 批准号: 9753364
• 负责人: Paul Muntner
• 金额: $ 36.23万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9753364
• 关键词: Acquired Immunodeficiency Syndrome; Adult; African American; Alabama; Area; Blood; Cardiovascular Diseases; Centers for Disease Control and Prevention (U.S.); Clinic; Cohort Studies; Collaborations; Disease; Educational workshop; Ethnic group; Fostering; Foundations; Funding; Geographic Locations; Goals; Grant; HIV; Heart; Hypertension; Incidence; Individual; Lead; Life Expectancy; Lipids; Lung; Mentored Clinical Scientist Development Program; Mentors; Mentorship; NCI Scholars Program; National Heart, Lung, and Blood Institute; Patients; Prevalence; Principal Investigator; Program Development; Race; Records; Research; Research Methodology; Research Personnel; Research Project Grants; Research Training; Rotation; SECTM1 gene; Science; Site; Sleep; Southeastern United States; Training; Training Programs; Universities; antiretroviral therapy; career development; design; didactic education; experience; high risk; method development; online course; programs; recruit; skill acquisition; training opportunity

The Centers for Disease Control (CDC) has estimated there were more than 1.1 million people in the US living with HIV in 2014. Effective antiretroviral therapy (ART) has increased the life expectancy of HIV+ individuals and the number of US adults living with HIV is projected to increase by almost 40% over the next decade. This has created a new challenge for people living with HIV in the US. People living with HIV have a high risk for heart, lung, blood and sleep related diseases (NHLBI-targeted diseases). Furthermore, the prevalence and incidence of both HIV and NHLBI-targeted diseases are higher among African Americans compared with other race/ethnic groups and in the South compared with other regions of the US. Despite the recognized importance of NHLBI-targeted diseases in people with HIV, few researchers have been trained in this area. The University of Alabama at Birmingham (UAB) is exceptionally well-suited to lead an institutional K12 Career Development Program in HIV-related heart, lung, blood and sleep research. The burden of HIV and NHLBI- targeted diseases is higher in the Southeast US compared with other geographic regions. The overall objective of this K12 grant is to develop and sustain a training program for scholars to gain interdisciplinary, intensive mentored research training and career development to become research leaders in the field of HIV- related heart, lung, blood and sleep disease. To accomplish this goal, we have designed a career development program that is interdisciplinary, involves didactic and experiential training opportunities, and contains intensive mentorship. The key activities we propose include to (1) develop and deliver an intensive, didactic curriculum with research rotations for additional skill development, (2) identify and recruit five scholars for training to conduct heart, lung, blood and sleep-related research in the context of HIV, (3) provide career development support through individual and team mentoring, (4) foster interdisciplinary team-science, and (5) provide tailored research projects for scholars to lead. The UAB program will collaborate with the other K12 awardees from this NHLBI program to maximize opportunities and experiences received by scholars through coordinating activities, including online courses. We will build this program on a strong foundation at UAB including (1) the Center for AIDS Research (CFAR), (2) a clinic site for major HIV studies (e.g., WIHS and REPRIEVE), (3) ongoing NHLBI-funded cohort studies (e.g., CARDIA), (4) a large pool of established senior mentors, (5) established research methods and career development workshops, (5) long-standing T32 and K12 training programs and (6) a CTSA. Also, the co-Principal Investigators for this grant have complimentary experience leading cardiovascular disease (Dr. Muntner) and HIV (Dr. Overton) research, strong track-records mentoring scholars towards independence, and an established research collaboration involving lipids and hypertension among patients with HIV. By completion of the K12 program, scholars be prepared to assemble, launch and lead interdisciplinary teams conducting HIV-related heart, lung, blood and sleep research.

美国疾病控制中心 (CDC) 估计，美国有超过 110 万人生活在 2014 年感染 HIV。有效的抗逆转录病毒治疗 (ART) 延长了 HIV+ 个体的预期寿命 未来十年，美国成年人感染艾滋病毒的人数预计将增加近 40%。这 给美国艾滋病毒感染者带来了新的挑战。艾滋病毒感染者有很高的风险 心、肺、血液和睡眠相关疾病（NHLBI 目标疾病）。此外，患病率和 与其他人相比，非裔美国人的 HIV 和 NHLBI 目标疾病的发病率更高 种族/族裔群体以及南方与美国其他地区的比较。尽管公认 虽然 NHLBI 目标疾病对于 HIV 感染者的重要性，但很少有研究人员接受过该领域的培训。 阿拉巴马大学伯明翰分校 (UAB) 非常适合领导机构 K12 职业生涯 与艾滋病毒相关的心脏、肺、血液和睡眠研究发展计划。 HIV 和 NHLBI 的负担 与其他地理区域相比，美国东南部的目标疾病发病率更高。整体 这项 K12 补助金的目标是为学者制定和维持一个培训计划，以获得跨学科、 强化指导研究培训和职业发展，成为艾滋病毒领域的研究领导者 相关心、肺、血液和睡眠疾病。为了实现这一目标，我们设计了一个职业生涯 跨学科的发展计划，涉及教学和体验式培训机会，以及 包含密集的指导。我们建议的关键活动包括 (1) 开发和提供密集的、 具有研究轮换的教学课程，以促进额外的技能发展，(2) 确定并招募五名学者 用于在艾滋病毒背景下进行心脏、肺、血液和睡眠相关研究的培训，(3) 提供职业 通过个人和团队指导提供发展支持，(4) 培养跨学科团队科学，以及 (5) 为学者领导提供量身定制的研究项目。 UAB 项目将与其他 K12 项目合作 该 NHLBI 计划的获奖者将通过以下方式最大限度地提高学者获得的机会和经验： 协调活动，包括在线课程。我们将在 UAB 的坚实基础上建立这个项目 包括 (1) 艾滋病研究中心 (CFAR)，(2) 主要艾滋病毒研究的临床中心（例如 WIHS 和 REPRIEVE），（3）正在进行的 NHLBI 资助的队列研究（例如 CARDIA），（4）大量已建立的高级研究人员 导师，(5) 建立研究方法和职业发展研讨会，(5) 长期存在的 T32 和 K12 培训计划和 (6) CTSA。此外，这项资助的联合首席研究员还免费获得 拥有领先的心血管疾病（Muntner 博士）和艾滋病毒（Overton 博士）研究经验，良好的记录 指导学者走向独立，并建立涉及脂质和 HIV 感染者的高血压。完成 K12 课程后，学者们准备好聚集， 启动并领导跨学科团队进行与艾滋病毒相关的心脏、肺、血液和睡眠研究。