UAB Institutional Career Development Program in HIV-Related Heart, Lung, Blood and Research

UAB 艾滋病毒相关心脏、肺、血液和研究机构职业发展计划

• 批准号: 9753364
• 负责人: Paul Muntner
• 金额: $ 36.23万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9753364
• 关键词: Acquired Immunodeficiency Syndrome; Adult; African American; Alabama; Area; Blood; Cardiovascular Diseases; Centers for Disease Control and Prevention (U.S.); Clinic; Cohort Studies; Collaborations; Disease; Educational workshop; Ethnic group; Fostering; Foundations; Funding; Geographic Locations; Goals; Grant; HIV; Heart; Hypertension; Incidence; Individual; Lead; Life Expectancy; Lipids; Lung; Mentored Clinical Scientist Development Program; Mentors; Mentorship; NCI Scholars Program; National Heart, Lung, and Blood Institute; Patients; Prevalence; Principal Investigator; Program Development; Race; Records; Research; Research Methodology; Research Personnel; Research Project Grants; Research Training; Rotation; SECTM1 gene; Science; Site; Sleep; Southeastern United States; Training; Training Programs; Universities; antiretroviral therapy; career development; design; didactic education; experience; high risk; method development; online course; programs; recruit; skill acquisition; training opportunity

The Centers for Disease Control (CDC) has estimated there were more than 1.1 million people in the US living with HIV in 2014. Effective antiretroviral therapy (ART) has increased the life expectancy of HIV+ individuals and the number of US adults living with HIV is projected to increase by almost 40% over the next decade. This has created a new challenge for people living with HIV in the US. People living with HIV have a high risk for heart, lung, blood and sleep related diseases (NHLBI-targeted diseases). Furthermore, the prevalence and incidence of both HIV and NHLBI-targeted diseases are higher among African Americans compared with other race/ethnic groups and in the South compared with other regions of the US. Despite the recognized importance of NHLBI-targeted diseases in people with HIV, few researchers have been trained in this area. The University of Alabama at Birmingham (UAB) is exceptionally well-suited to lead an institutional K12 Career Development Program in HIV-related heart, lung, blood and sleep research. The burden of HIV and NHLBI- targeted diseases is higher in the Southeast US compared with other geographic regions. The overall objective of this K12 grant is to develop and sustain a training program for scholars to gain interdisciplinary, intensive mentored research training and career development to become research leaders in the field of HIV- related heart, lung, blood and sleep disease. To accomplish this goal, we have designed a career development program that is interdisciplinary, involves didactic and experiential training opportunities, and contains intensive mentorship. The key activities we propose include to (1) develop and deliver an intensive, didactic curriculum with research rotations for additional skill development, (2) identify and recruit five scholars for training to conduct heart, lung, blood and sleep-related research in the context of HIV, (3) provide career development support through individual and team mentoring, (4) foster interdisciplinary team-science, and (5) provide tailored research projects for scholars to lead. The UAB program will collaborate with the other K12 awardees from this NHLBI program to maximize opportunities and experiences received by scholars through coordinating activities, including online courses. We will build this program on a strong foundation at UAB including (1) the Center for AIDS Research (CFAR), (2) a clinic site for major HIV studies (e.g., WIHS and REPRIEVE), (3) ongoing NHLBI-funded cohort studies (e.g., CARDIA), (4) a large pool of established senior mentors, (5) established research methods and career development workshops, (5) long-standing T32 and K12 training programs and (6) a CTSA. Also, the co-Principal Investigators for this grant have complimentary experience leading cardiovascular disease (Dr. Muntner) and HIV (Dr. Overton) research, strong track-records mentoring scholars towards independence, and an established research collaboration involving lipids and hypertension among patients with HIV. By completion of the K12 program, scholars be prepared to assemble, launch and lead interdisciplinary teams conducting HIV-related heart, lung, blood and sleep research.

疾病控制中心（CDC）估计美国有超过110万人生活 2014年艾滋病毒。有效的抗逆转录病毒疗法（ART）提高了HIV+个体的预期寿命 在未来十年中，美国成年人的数量预计将增加近40％。这 为在美国艾滋病毒感染者带来了新的挑战。感染艾滋病毒的人有高风险 心脏，肺，血液和睡眠与与NHLBI的疾病有关的疾病。此外，患病率和 与其他人相比 与美国其他地区相比，种族/族裔群体和南部。尽管公认 在艾滋病毒患者中，NHLBI靶向的疾病的重要性很少，研究人员在这一领域接受了培训。 伯明翰（UAB）的阿拉巴马大学非常适合领导机构K12职业 与HIV有关的心脏，肺，血液和睡眠研究中的发展计划。艾滋病毒和NHLBI的负担 与其他地理区域相比，美国东南部有针对性疾病更高。总体 这项K12赠款的目的是制定和维持一项培训计划，以供学者获得跨学科的培训计划， 密集的指导研究培训和职业发展，成为HIV领域的研究领导者 相关心脏，肺，血液和睡眠疾病。为了实现这一目标，我们设计了一个职业 跨学科的发展计划涉及教学和体验培训机会，以及 包含密集的指导。我们建议的关键活动包括（1）开发和提供密集的， 与研究旋转进行额外技能发展的教学课程，（2）识别和招募五个学者 在艾滋病毒背景下进行训练以进行心脏，肺，血液和与睡眠有关的研究，（3）提供职业 通过个人和团队指导的发展支持，（4）促进跨学科团队科学和（5） 为学者提供量身定制的研究项目。 UAB计划将与其他K12合作 该NHLBI计划的获奖者，以最大程度地利用学者通过 协调活动，包括在线课程。我们将在UAB的强大基础上建立该程序 包括（1）艾滋病研究中心（CFAR），（2）主要艾滋病毒研究的诊所（例如WIHS和 （3）正在进行的NHLBI资助的队列研究（例如Cardia），（4）大量已建立的高级资深 导师（5）建立的研究方法和职业发展研讨会，（5）长期存在的T32和 K12培训计划和（6）A CTSA。此外，这笔赠款的联合首席调查员有免费 经验领先的心血管疾病（Muntner博士）和HIV（Overton博士）研究，强大的田径记录 指导学者实现独立性，以及涉及脂质和的既定研究合作 HIV患者的高血压。通过完成K12计划，学者准备组装， 启动和领导跨学科团队进行与HIV有关的心脏，肺，血液和睡眠研究。