World Trade Center Tissue Biobank

世界贸易中心组织生物库

• 批准号: 9607412
• 负责人: EMANUELA TAIOLI
• 金额: $ 49.4万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9607412
• 关键词: World; Trade; Center; Tissue; Biobank

Immediately after the 9/11 terrorist attack, concerns were raised about the short and long term effects of exposure to the World Trade Center (WTC) dust cloud. Responders and residents were exposed to a complex mixture of toxic chemicals that included multiple known and suspected human carcinogens which could increase cancer risk. For most solid cancers, the relevant time window between exposure and cancer occurrence is approaching right now, 16 years after the event. The WTCHP has completed the follow-up of all the respondents up to 2014, and has confirmed a possible increase in thyroid and prostate cancers, where the possibility of a biologically more aggressive cancer type due to the nature of the environmental exposure in this population has not been discounted. In parallel with the biomarkers human studies, experimental animal studies of the systemic and local effects of controlled exposure to WTC dust have been conducted, to complement and help interpreting the epidemiological and biomarkers observations reported in the WTC responders cohort. We propose to update the existing biobank of human solid organ tissues from each cancer diagnosed among the WTC rescue and recovery workers, and to include a central repository of tissue samples from various relevant organs from all the animal experiments involving exposure to WTC dust, in order to facilitate and promote future clinical research and translational studies on cancer etiology, cancer biology and cancer outcome. This project proposes to update the central repository of cancer tissue samples and adjacent normal tissue from each solid cancer diagnosed among the WTC Health Program (WTCHP) participants. Relevant information from pathology and cytology reports from each cancer is also centrally stored. This repository has the capability to be linked with the main WTCHP data set containing clinical, epidemiological and exposure information, as well as with the peripheral blood sample collected from the participants at the time of inclusion in the WTCHP. We also propose to initiate and manage a central repository of tissue samples from various organs from rodents exposed to WTC dust at Mount Sinai and NYU. Relevant information from pathology reports will also be centrally stored, along with details of the exposure amount and duration, and of the experimental design. We establish the tissue bank as a resource for the science community, by defining a process for qualified applicants to request available samples for research use, and for linking with the epidemiologic and clinical information in the database. A plan for the evaluation of the tissue bank usage and success, as measured by publications and funding obtained by investigators using the samples, is also included.

9/11恐怖袭击后，立即对短期和长期提出了担忧 暴露于世界贸易中心（WTC）尘埃云的影响。响应者和居民是 暴露于有毒化学物质的复杂混合物中，其中包括多个已知和可疑的 人类致癌物可能会增加癌症风险。对于大多数固体癌症，相关时间 暴露与癌症发生之间的窗口正在接近 事件。 WTCHP已完成所有受访者的后续活动，直到2014年， 确认甲状腺和前列腺癌可能会增加 由于环境暴露的性质，生物学上更具侵略性的癌症类型 人口尚未打折。与生物标志物人类研究并行实验 动物研究受控暴露于WTC尘埃的系统和局部影响已经是 进行，以补充和帮助解释流行病学和生物标志物观察 在WTC响应者队列中报告。我们建议更新人类现有的生物库 WTC救援和恢复中诊断出的每种癌症的固体器官组织 工人，并包括来自各种相关的组织样品的中央存储库 来自所有涉及暴露于WTC尘埃的动物实验的器官 促进和促进未来的临床研究和癌症病因的翻译研究， 癌症生物学和癌症结果。该项目建议更新中央存储库 癌症组织样品和来自诊断出的每个固体癌症的邻近正常组织 WTC健康计划（WTCHP）参与者。病理学和细胞学的相关信息 每个癌症的报告也被集中存储。该存储库具有链接的功能 主要WTCHP数据集包含临床，流行病学和暴露信息， 以及在纳入参与者时从参与者那里收集的外周血样本 WTCHP。我们还建议从 啮齿动物的各种器官在西奈山和纽约大学暴露于WTC尘埃。相关信息 从病理报告中也将集中存储，以及暴露金额的详细信息和 持续时间和实验设计。我们将组织库建立为 科学界，定义合格申请人的过程，要求可用样本 研究用途，以及与数据库中的流行病学和临床信息链接。一个 按照出版物和 研究人员使用样品获得的资金也包括在内。