International Research Collaboration on Neuroimaging Studies of Alcoholism

酒精中毒神经影像学国际研究合作

• 批准号: 9042901
• 负责人: Adolf Pfefferbaum
• 金额: $ 24.78万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2020-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9042901
• 关键词: Accounting; Alcohol Amnestic Disorder; Alcohol consumption; Alcoholism; Alcohols; Award; Basic Science; Behavioral; Biological; Biological Markers; Blood; Brain; Chronic; Cognitive; Collaborations; Country; DSM-V; Data; Data Analyses; Data Collection; Diagnostic; Doctor of Medicine; Doctor of Philosophy; Episodic memory; Ethnic Origin; Fiber; Folic Acid; France; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Genes; Genetic Markers; Genotype; Health; Hematocrit procedure; Hemoglobin; Heterogeneity; Hippocampus (Brain); Homocysteine; Homocystine; Hospitals; Human; International; Korea; Koreans; Laboratories; Magnetic Resonance Imaging; Measures; Memory; Motor; NIH Program Announcements; National Institute on Alcohol Abuse and Alcoholism; Nervous system structure; Neuraxis; Neuropsychology; Neurosciences; Nutritional; Nutritional status; Outcomes Research; Patients; Pattern; Principal Investigator; Procedures; Protocols documentation; Recording of previous events; Recovery; Red Blood Cell Count; Research; Research Personnel; Rest; Risk Factors; Scientist; Secure; Single Nucleotide Polymorphism; Site; South Korea; Structure; System; Testing; Thalamic structure; Therapeutic; Thiamine; Thiamine Pyrophosphate; Translational Research; U-Series Cooperative Agreements; United States; Universities; Variant; Visit; Wernicke-Korsakoff Syndrome; Whole Blood; Work; Writing; addiction; alcohol effect; brain volume; cerebrovascular; genetic variant; indexing; interest; mean corpuscular volume observed; neuroimaging; neuropsychological; nutrition; problem drinker; programs; relating to nervous system; response

DESCRIPTION (provided by applicant): This application for a competing renewal of a U01 cooperative agreement award is written in response to Program Announcement (PA) number PAR-11-282, "International Research Collaboration on Alcohol and Alcoholism." Receipt of this award would enable us to continue a program of international collaborations among the well-established nationally funded research groups at INSERM/University of Caen site in France directed by Francis Eustache, Ph.D., the recently-established addictions research program at the Yonsei University affiliated Severance Hospital in Seoul, South Korea directed by Young-Chul Jung, M.D., Ph.D., and our longstanding neuroimaging and neuroscience laboratories funded principally by NIAAA, in the United States at Stanford University with Edith Sullivan, Ph.D., Principal Investigator (MPI) and at SRI International with Adolf Pfefferbaum, M.D. (MPI). The overarching aim of this collaboration is 1) to use neuroimaging, neuropsychology, and biomarkers of nutrition in alcoholics, with and without KS, and controls to compare and contrast the effects of alcohol on brain structure and function across nations and 2) to identify markers of nutritional status, genetic variants, and alcohol consumption patterns that modulate the principal dependent measures and explain heterogeneity in presentation and recovery of alcoholism. Three specific aims with testable hypotheses are proposed: 1. Prospectively screen with common diagnostic DSM-V criteria 100 alcoholics, 100 controls, and 10 KS in each country-U.S., France, and South Korea-and acquire the following data: 1a. Neuroimaging (MRI, FLAIR, DTI, and rs-fMRI) data using common protocols developed over the current funding period. 1b. Neuropsychological data using the common long and newly developed short test batteries. 1c. Blood for analysis of biomarkers of nutritional status (hemogram for red blood cell count, hematocrit, hemoglobin, mean corpuscular volume; vitamin B1 (whole blood thiamine diphosphate), folate, B12 and cerebrovascular risk factor (homocysteine). 1.d. Blood for analysis of thiamine transporter genotyping 2. Implement a secure pipeline for data reception, storage, analysis, and dissemination to and from project sites. 3. Conduct data analysis and hypothesis testing in collaboration with the project scientists (French and Korean visiting the U.S. and U.S. visiting France and Korea) and export results and analysis procedures to France and Korea.

描述（由申请人提供）：本申请申请U01合作协议奖的竞争申请是为了回应计划公告（PA）数字PAR-11-282，“国际酒精和酒精中毒研究合作”。获得该奖项的收到将使我们能够在法国的Inserm/Caen大学的全国资助研究小组中继续进行国际合作计划，该小组由Francis Eustache博士执导，该计划是Youse University of Seolance Hospital of Young-Chul-Chungung，M.D. and M.D.的Youse University section sectral declance Hospital and Younge and ph。神经科学实验室主要由NIAAA资助，在美国斯坦福大学，伊迪丝·沙利文（Edith Sullivan）博士，首席研究员（MPI）和SRI International与Adolf Pfefferbaum，M.D。（MPI）的SRI International。这项合作的总体目的是1）使用酗酒者的神经影像学，神经心理学和营养生物标志物，有或没有KS，以及控制和对比，以比较和对比酒精对跨国家的大脑结构和功能的影响以及2）识别 营养状况，遗传变异和酒精消耗模式，这些模式调节主要依赖性措施并解释酒精中毒的表现和恢复中的异质性。提出了具有可检验的假设的三个特定目标：1。具有常见的DSM-V标准的前瞻性筛选100酗酒者，100个对照和10 ks，在每个国家 /地区，法国和韩国，并获取以下数据：1A。神经影像学（MRI，FLAIR，DTI和RS-FMRI）数据使用当前资金期间开发的共同协议。 1B。使用常见的长期和新开发的短测试电池的神经心理学数据。 1C。血液用于分析营养状况的生物标志物（红细胞计数，血细胞核，血红蛋白，平均红细胞体积的血液图；维生素B1（全血硫胺二磷酸），叶酸，B12，B12和脑血管血管血管造风险因子（共生型）的血液（共生性分析）。向3号项目进行分发。