N-CANDA: Data Analysis Component

N-CANDA：数据分析组件

• 批准号: 8544964
• 负责人: Adolf Pfefferbaum
• 金额: $ 74.93万
• 依托单位: SRI INTERNATIONAL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-15 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8544964
• 关键词: Abstinence; Address; Adolescence; Adolescent; Adolescent Development; Adverse effects; Affect; Affective; Age; Alcohol abuse; Alcohol consumption; Alcohol or Other Drugs use; Alcoholism; Alcohols; Anatomy; Archives; Atlases; Behavioral inhibition; Biological Neural Networks; Brain; Brain imaging; Clinical; Clinical Data; Clinical assessments; Cognitive; Collection; DNA; Data; Data Analyses; Databases; Deposition; Detection; Development; Diffusion Magnetic Resonance Imaging; Dose; Ensure; Family history of; Fiber; Functional Magnetic Resonance Imaging; Future; Heavy Drinking; High Prevalence; Image; Image Analysis; Informatics; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Mediating; Mining; Monitor; Neurocognitive; Neuropsychological Tests; Pattern; Performance; Physiologic pulse; Physiological; Physiology; Procedures; Process; Protocols documentation; Psychopathology; Quality Control; Recovery; Regulation; Research; Research Infrastructure; Research Personnel; Resolution; Rest; Retrieval; Rewards; Risk Factors; Role; Sampling; Science; Site; Sleep; Sleep Stages; Structure; System; Testing; Time; alcohol abstinence; alcohol effect; alcohol exposure; alcohol use disorder; base; computerized data processing; data integration; data mining; design; disorder risk; heavy drinking during adolescence; imaging modality; longitudinal design; neurodevelopment; neuroimaging; neuropsychological; programs; prospective; psychologic; relating to nervous system; response; sex; underage drinking; white matter; young adult

DESCRIPTION (provided by applicant): The National Consortium on Alcohol and NeuroDevelopment in Adolescence (N-CANDA) proposes a longitudinal study of developmental trajectories of brain structure, function, and physiology and their alteration by adolescent alcoho exposure. The prospective design will assess young people before the start of any significant substance use, thereby facilitating identification of antecedent conditions influencing the development of Alcohol Use Disorder (AUD) and the effects thereafter. A synergistic program to assess dependent-variable domains (clinical, neuropsychological, physiological, brain structural and functional), quantified and tracked longitudinally will be combined across 4 collection sites to create a large and rich body of data. An accelerated longitudinal design allows for construction of trajectories over the entire adolescent age range and encompasses the period of brain structural and functional development during the vulnerable time of AUD emergence. The investigators of the N- CANDA Data Analysis, Integration, and Informatics Component will provide fundamental neuroimaging science support for MRI pulse sequence development, acquisition, and analysis protocols. This component will also provide the infrastructure for deposition, organization, storage, archiving, retrieval, and initial analysis of neuroimaging, neuropsychological, and clinical data collected at all four N- CANDA acquisition sites. The Specific Aims of the Data Analysis, Integration, and Informatics Component are to: Aim 1. Develop procedures for collection of neuroimaging, neuropsychological, and clinical assessment data harmonized with existing large-scale neurodevelopmental research efforts. Aim 2. Ensure that quality control measures are in place at each site for the acquisition of imaging data. Aim 3. Develop the informatics infrastructure for data submission, database construction, data analysis, integration, and distribution for all N-CANDA sites through a query system that allows exploration of the multiple domains of the database. Aim 4. Provide a pipeline for macrostructural, microstructural and functional neuroimage data processing and analysis. Aim 5. Develop informatics processes to coordinate the combining of data and the analysis of results across and within research components for a priori hypothesis testing and association discovery and atheoretical data mining in search of relations not previously considered. !

描述（由申请人提供）：青春期酒精和神经发育的国家联盟（N-CANDA）提出了对大脑结构，功能和生理学发育轨迹的纵向研究，以及通过青少年酒精暴露的改变。前瞻性设计将在开始任何大量物质使用之前评估年轻人，从而促进影响饮酒障碍发展（AUD）及其后影响的前期疾病的鉴定。评估因变量域（临床，神经心理学，生理，大脑结构和功能）的协同程序，将在4个收集地点组合进行量化和纵向跟踪，以创建大量且丰富的数据。加速的纵向设计允许在整个青少年年龄范围内构建轨迹，并涵盖了易于出现的脆弱时间，涵盖了大脑结构和功能发展的时期。 N-CADDA数据分析，集成和信息学组件的研究者将为MRI脉冲序列开发，获取和分析方案提供基本的神经影像学支持。该组成部分还将提供用于沉积，组织，存储，归档，检索的基础架构，以及在所有四个N- CANDA采集地点收集的神经影像，神经心理学和临床数据的初步分析。数据分析，集成和信息学组件的具体目的是：目标1。开发收集神经成像，神经心理学和临床评估数据与现有的大规模神经发育研究工作一致的程序。目标2。确保每个站点都采取质量控制措施以获取成像数据。目标3。 通过查询系统为所有N-canda站点的数据提交，数据库构建，集成和分布开发信息学基础架构，该问题允许探索数据库的多个域。 AIM 4。为宏观结构，微结构和功能神经图像数据处理和分析提供管道。目标5。开发信息学过程，以协调数据的组合以及研究组件和内部的结果分析，以进行先验假设检验和关联发现和理论数据挖掘，以寻找以前不考虑的关系。呢