A mechanistic study of prenatal air pollution exposure and offspring obesity risk

产前空气污染暴露与后代肥胖风险的机制研究

• 批准号: 9490474
• 负责人: Anne Starling
• 金额: $ 24.48万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9490474
• 关键词: Address; Adolescent; Affect; Age; Air; Air Pollutants; Air Pollution; Aromatic Polycyclic Hydrocarbons; Award; Biological; Biological Factors; Biometry; Birth; Blood Cells; Body Composition; Body mass index; Carbon Monoxide; Centers for Disease Control and Prevention (U.S.); Child; Childhood; Chronic Disease; Cohort Studies; Collaborations; DNA Methylation; Data; Development; Diet; Ecology; Environmental Epidemiology; Environmental Exposure; Environmental Pollutants; Environmental Risk Factor; Epidemiologic Methods; Epidemiologist; Epidemiology; Epigenetic Process; Evaluation; Exposure to; Faculty; Fatty acid glycerol esters; Follow-Up Studies; Genomics; Geographic Information Systems; Geography; Growth; Health; Height; Infant; Inflammation; Inflammation Mediators; Informatics; Interleukin-6; K-Series Research Career Programs; Lead; Life; Link; Longitudinal cohort; Maternal Exposure; Measurement; Measures; Mediating; Mediation; Mediator of activation protein; Mentors; Metabolic; Metabolic Diseases; Methods; Modeling; Modification; Morbidity - disease rate; Mothers; Obesity; Outcome; Overweight; Parents; Particulate; Particulate Matter; Pathway interactions; Phase; Play; Plethysmography; Pregnancy; Pregnant Women; Prevention; Reporting; Research; Risk; Role; Sampling; Science of genetics; Serum; Specimen; Statistical Methods; TNF gene; Techniques; Toxic Environmental Substances; Training; Umbilical Cord Blood; Umbilical cord structure; Visit; Weights and Measures; Work; atmospheric sciences; base; cardiovascular disorder risk; career; cohort; density; disorder prevention; disorder risk; early childhood; early life exposure; environmental chemical; epidemiology study; epigenetic marker; experience; fetal; gestational weight gain; in utero; inflammatory marker; lifetime risk; maternal cigarette smoking; maternal obesity; methylation biomarker; mortality; obesity in children; obesity risk; offspring; postnatal; prenatal; prenatal exposure; prenatal influence; prevent; public health priorities; public health relevance; skills; spatial epidemiology; traffic-related air pollution

 DESCRIPTION (provided by applicant) The prevention of childhood obesity is an urgent public health priority. The Centers for Disease Control and Prevention reported that 17% of children and adolescents in the US had obesity in 2012, and children with obesity may experience higher lifetime risks of age-specific morbidity and mortality. Environmental exposures in early life may promote the development of obesity and related adverse cardio-metabolic outcomes in children. Specifically, maternal exposure to particulate and gaseous air pollutants during pregnancy may lead to programming of offspring adiposity and altered postnatal growth trajectories. Previous epidemiologic studies have identified associations between air pollution exposure and childhood overweight or obesity, but have rarely looked at exposures in the prenatal period, or measured biological factors in the mother or infant that could mediate the observed relationship. The proposed research is an in-depth evaluation of the role that prenatal exposure to traffic-related air pollution may play in offspring adiposity and early childhood overweight and obesity, considering as mediators both inflammatory markers in maternal and umbilical cord blood, and epigenetic markers of DNA methylation in umbilical cord blood. The overall aim of this Career Development Award is to advance the candidate into an independent research career in environmental epidemiology, with an emphasis on the long-term health effects of exposure to environmental toxicants during the prenatal period. The analytical skills acquired during the mentored training period of this award will include the use of geographic information systems-based methods of spatial exposure assessment and modeling, the implementation of advanced statistical methods to evaluate possible causal mediation, and the analysis and interpretation of epigenetic markers in epidemiologic studies. These skills will be developed through mentored independent study, course work, and collaboration with experienced faculty in the fields of Epidemiology, Geography and Environmental Sciences, Atmospheric Science, Genetics and Genomics, and Biostatistics and Informatics. The candidate will use spatial modeling methods to estimate residential exposure to traffic-related air pollution during pregnancy in an existing longitudinal pre-birth cohort study focused on the developmental origins of obesity and related cardio-metabolic disorders. Stored maternal and umbilical cord serum samples will be analyzed for markers of systemic inflammation, which may be linked to traffic-related air pollution exposure and also to offspring risk for overweight and obesity. During the independent period of the award, the candidate will use the exposure assessment developed in the mentored period to estimate associations between prenatal exposure to traffic-related air pollution and offspring adiposity and obesity. Maternal and fetal systemic inflammation and offspring DNA methylation in umbilical cord blood will be investigated as possible mediators of the association. The project will make a substantial contribution to the field of air pollution epidemiology and the early-life environmental factors that influence childhood obesity risk.

 描述（由申请人提供） 疾病控制中心和预先预先认为，2012年，美国的N和青少年中有17％的人患有肥胖症，肥胖症的儿童可能会终生寿命特定年龄的风险以及n。尤其是在以前的流行性轨迹的后代和D后，空气污染可能会导致空气污染暴露与cild污染和肥胖期之间的表演中的生长轨迹。关系。h评估与交通交通相关的andiprutity adpring和早期的choodo肥胖奖励期间的暴露有毒物质的第三影响。在流行病学，大气科学，遗传学和基因组学以及生物统计学和信息学领域与经验丰富的教师合作。 。流行病学和影响儿童肥胖风险的早期长颈。