The Subgingival Microbiome in Non-Hispanic Black Women: Relationship to Periodontal Inflammation, Systemic Inflammation, and Preterm Birth

非西班牙裔黑人女性的龈下微生物群：与牙周炎症、全身炎症和早产的关系

• 批准号: 9453361
• 负责人: Irene Yang
• 金额: $ 8.89万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-19 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9453361
• 关键词: 37 weeks gestation; Affect; Appearance; Area; Behavioral; Birth; Birth Rate; Cardiovascular system; Communities; Data; Data Analyses; Developed Countries; Development; Ecology; Educational workshop; Enrollment; Environment; Environmental Risk Factor; Equilibrium; Etiology; Face; Forsythia; Funding; Future; Gestational Age; Gingiva; Goals; Health Promotion; Immune response; Individual; Infection; Inflammation; Inflammation Mediators; Inflammatory; Interdisciplinary Study; Intervention; Investigation; Knowledge; Maternal Health; Mentors; Metagenomics; Methodology; Morbidity - disease rate; Movement; Newborn Infant; Not Hispanic or Latino; Oral; Oral cavity; Oral health; Organism; Outcome; Parents; Participant; Pathway interactions; Periodontal Diseases; Periodontal Infection; Physiological; Play; Population; Porphyromonas gingivalis; Pregnancy; Pregnant Women; Premature Birth; Premature Infant; Prevalence; Prevention; Prevention strategy; Public Health; Research; Research Personnel; Research Proposals; Ribosomal RNA; Risk; Risk Factors; Role; Serum; Source; Structure; Techniques; Training; Treponema denticola; Underserved Population; United States; Vagina; Woman; Yang; biobehavior; career; career development; cytokine; design; ethnic minority population; experience; fetal; health disparity; indexing; infant death; innovation; microbial; microbial community; microbiome; microorganism; minority health; modifiable risk; mortality; oral microbiome; pathogen; periopathogen; pregnant; prenatal; prevent; programs; racial and ethnic; social; socioeconomics; subgingival biofilm

Project Summary/Abstract Preterm birth occurs at < 37 weeks gestation. It is associated with a host of newborn risks that increase the risk of preterm related infant death. The United States leads other industrialized nations in preterm birth rate and, for reasons unknown, non-Hispanic Black women in the U.S. have a 50% higher preterm birth rate compared to the overall national prevalence. Current preterm prevention strategies are limited due to lack of understanding about the underlying mechanisms of preterm birth. The association between intrauterine infection and preterm birth is well-established. Emerging research suggests that periodontal disease may be an etiologic source of this infection. Periodontal disease is an inflammatory condition that begins as a direct immune response to microorganisms that inhabit the subgingival biofilm. Pregnant women and racial/ethnic minorities are particularly at risk for periodontal disease. Gingival inflammation during pregnancy may allow for the movement of inflammatory products into the circulatory system and to the maternal-fetal unit, triggering an inflammatory cascade which may increase the likelihood of preterm birth. Critical to understanding the association between periodontal disease and preterm birth, is an understanding of the subgingival microbiome. This study, therefore, aims to: 1) Characterize the structure and diversity of the subgingival microbiome and of pregnant non-Hispanic Black women in early and late pregnancy. 2) Explore the relationship between the subgingival microbiome and localized inflammation. 3) Explore associations between localized and systemic inflammation, and gestational age at birth. Results from this study will inform an innovative approach to the assessment and intervention of periodontal disease in pregnant women as a potential modifiable target risk factor for preterm birth, thereby promoting maternal health, and preventing adverse birth outcomes for women and their newborns. The overarching goal of this K01 career development proposal is the development of Dr. Yang’s expertise in three areas: microbiome data analysis, oral health research, and health disparities research. The proposed project, in conjunction with the structured mentoring and training plan which includes didactic courses, workshops, and hands-on experience, are designed to facilitate this goal, as well as Dr. Yang’s long-term goal of developing an independently-funded biobehavioral research program that investigates how physiologic mechanisms combine with social, behavioral and environmental factors to give rise to maternal health disparities.

项目概要/摘要 早产发生在妊娠 < 37 周时，它与增加新生儿风险有关。 美国的早产率领先于其他工业化国家。 而且，由于未知的原因，美国非西班牙裔黑人女性的早产率要高出 50% 与全国总体患病率相比，目前的早产预防策略由于缺乏相关措施而受到限制。 了解早产的潜在机制。 最新研究表明，牙周病可能与感染和早产有关。 这种感染的一个病因是牙周病是一种直接开始的炎症。 对存在于龈下生物膜中的微生物的免疫反应和种族/民族。 少数族裔特别容易患牙周病，怀孕期间牙龈发炎可能会导致这种情况。 炎症产物进入循环系统和母胎单位，引发 炎症级联反应可能会增加早产的可能性。 牙周病与早产之间的关联，是对龈下微生物组的了解。 因此，本研究的目的是： 1) 表征龈下微生物组和怀孕的非西班牙裔黑人的结构和多样性 怀孕早期和晚期的妇女。 2）探索龈下微生物组与局部炎症之间的关系。 3) 探索局部和全身炎症与出生胎龄之间的关联。 这项研究的结果将为牙周病评估和干预的创新方法提供信息 孕妇疾病作为早产的潜在可改变目标危险因素，从而促进 孕产妇健康，以及预防妇女及其新生儿的不良分娩结果。 K01职业发展建议的重点是发展杨博士在三个领域的专业知识： 微生物组数据分析、口腔健康研究和健康差异研究。 结合结构化的指导和培训计划，包括教学课程、研讨会和 实践经验，旨在促进这一目标，以及杨博士开发一个 独立资助的生物行为研究项目，研究生理机制如何结合 社会、行为和环境因素导致孕产妇健康差异。