ShEEP Request for Heidelberg Spectralis Tracking OCT System - HRA+OCT with OCT2 Multicolor

ShEEP 请求海德堡 Spectralis 跟踪 OCT 系统 - HRA OCT 与 OCT2 多色

• 批准号: 9362000
• 负责人: Matthew M. Harper
• 金额: --
• 依托单位: IOWA CITY VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-01-01 至 2017-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9362000
• 关键词: Achievement; Affect; Algorithmic Analysis; Angiography; Animals; Blindness; Choroid; Cities; Collection; Complications of Diabetes Mellitus; Computer software; Cornea; Country; Disease; Dyes; Engineering; Ensure; Equipment; Experimental Models; Eye; Functional disorder; Funding; Generations; Glaucoma; Health; Healthcare; Image; Image Analysis; Injectable; Iowa; Mus; Optical Coherence Tomography; POU2F2 gene; Patients; Perfusion; Prevention; Program Evaluation; Radiation; Request for Applications; Research; Research Personnel; Retina; Retinal; Retinal Diseases; Scanning; Sheep; Stress; Structure; System; Technology; Traumatic Brain Injury; Veterans; Vision research; Visual; imaging capabilities; improved; in vivo; instrument; interest; mitochondrial dysfunction; multidisciplinary; programs; retinal damage; treatment response

With this application we request funds from the ORD Shared Equipment Evaluation Program (SHEEP) to purchase a new generation Optical Coherence Tomography (OCT) unit with OCT- angiography (OCT-A) capabilities. Specifically, we seek to obtain a Heidelberg Engineering Spectralis Tracking OCT System - HRA+OCT w/OCT2 – MultiColor and Heidelberg Engineering Widefield Imaging Module. This instrument will be shared among investigators within the Department of Veterans Affairs Center for the Prevention and Treatment of Visual Loss (CPTVL). The rationale for our purchase is twofold. First, our current OCT, a Heidelberg Engineering HRA-OCT is becoming outdated and cannot be upgraded to a newer OCT-A mode. Second, the new version of the Spectralis HRA-OCT instrument offers several scientific advantages over the older version, which include the ability to image retinal vasculature without the need to inject dye into the animal. The investigators that are submitting this proposal are all investigators within the Iowa City VA Center for the Prevention and Treatment of Visual Loss. All investigators are interested in discovering the causes of various forms of visual loss and developing new treatments for visual loss to help affected Veterans. The research portfolio of investigators within with proposal is diverse with respect to visual loss. These include radiation-induced retinal damage, glaucoma, visual loss related to traumatic brain injury, mitochondrial dysfunction, retinal complications of diabetes, outer retinal visual loss, image analysis of retinal diseases and corneal damage and dysfunction. Thus, acquisition of a Heidelberg Spectralis HRA+OCT with OCT-A and Multicolor analysis will enhance the ability of investigators at the Iowa City VA to determine the causes of visual loss in mice through retinal imaging. This instrument will also integrate seamlessly with our multi-disciplinary image analysis team, which will allow us to extract a maximum amount of information from each animal subject.

在此申请中，我们要求从ORD共享设备评估计划中的资金 （绵羊）购买新一代的光学连贯层析成像（OCT）单元 血管造影（OCT-A）功能。具体来说，我们寻求获得海德堡工程光谱 跟踪OCT系统-HRA+OCT W/OCT2 - 多色和海德堡工程广场 成像模块。该工具将在部门内的调查人员之间共享 退伍军人事务中心预防和治疗视觉损失（CPTVL）。 我们购买的理由是双重的。 首先，我们目前的10月，海德堡工程HRA-OCT已经过时，不能是 升级到较新的Oct-A模式。第二，Spectralis HRA-OCT仪器的新版本 比较旧版本提供了几个科学优势，其中包括再次形象的能力 无需将染料注入动物的脉管系统。 提交该建议的调查人员都是爱荷华城弗吉尼亚州中心的调查员 用于预防和治疗视觉丧失。所有调查人员都有兴趣发现 各种形式的视觉丧失的原因并开发新的治疗方法以帮助受到影响 退伍军人。提案中的调查人员的研究组合在视觉上是潜水员 损失。这些包括辐射引起的残留损害，青光眼，与创伤性大脑有关的视觉损失 损伤，线粒体功能障碍，糖尿病的视网膜并发症，视网膜外视觉丧失，图像 分析残留疾病，角膜损伤和功能障碍。 这是，通过OCT-A和多色分析获得Heidelberg Spectralis HRA+OCT 增强爱荷华州弗吉尼亚州的研究人员确定小鼠视觉丧失原因的能力 通过视网膜成像。该乐器还将与我们的多学科无缝集成 图像分析团队，这将使我们能够从每个 动物主题。