Immunology Core

免疫学核心

• 批准号: 9248255
• 负责人: David A Rasko
• 金额: $ 18.86万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9248255
• 关键词: Address; Animal Model; Award; Communicable Diseases; Data; Data Analyses; Databases; Diagnosis; Dimensions; Disease; Disease Outcome; Enteral; Genomic approach; Goals; Human; Immune response; Immunologics; Immunology; Individual; Infection; Infectious Agent; Knowledge; Malaria; Manuscripts; Measurement; Measures; Parasites; Plasmodium falciparum; Preparation; Reporting; Research; Research Project Grants; Resources; Techniques; Technology; Vaccines; Vibrio cholerae; cost effective; data management; enterotoxigenic Escherichia coli; experience; instrumentation; microbiome; pathogen; prevent; vaccine development

Immune responses are of paramount importance in protection from infectious diseases and vaccines are an exceedingly cost-effective measure to prevent these illnesses. Despite considerable progress, the immunological correlates of protection from enteric infections and malaria, as well as other infectious agents that form part of this Ul 9 application remain unknown. To address these major gaps in knowledge, we will establish an Immunology Core that will generate unique immunological data to be correlated with microbiome, P. falciparum, V. cholerae, ETEC and other unique sequencing data resulting from studies proposed in this U19 application to address unexplored and critical new aspects of host-parasite interactions. The PI of this Immunology Core and his team are extremely experienced in the study of immune responses to infectious agents and vaccine development in humans and animal models using state-of-the-art techniques and instrumentation.

免疫反应在保护免受传染病和疫苗的保护中至关重要 非常具有成本效益的措施，以防止这些疾病。尽管进步很大，但 免受肠道感染和疟疾以及其他感染剂的保护的免疫学相关性 该UL 9应用程序的一部分仍然未知。为了解决知识上的这些主要差距，我们将 建立一种免疫学核心，该核心将生成独特的免疫数据以与之相关 Microbiome，P。falciparum，V。Cholerae，ETEC和其他研究由研究产生的独特测序数据 在本U19应用程序中提出的，以解决宿主 - 寄生虫相互作用的未开发和关键的新方面。 该免疫学核心及其团队的PI在免疫反应的研究中经验丰富 使用最先进 技术和仪器。