Immunology Core

免疫学核心

• 批准号: 9248255
• 负责人: David A Rasko
• 金额: $ 18.86万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9248255
• 关键词: Address; Animal Model; Award; Communicable Diseases; Data; Data Analyses; Databases; Diagnosis; Dimensions; Disease; Disease Outcome; Enteral; Genomic approach; Goals; Human; Immune response; Immunologics; Immunology; Individual; Infection; Infectious Agent; Knowledge; Malaria; Manuscripts; Measurement; Measures; Parasites; Plasmodium falciparum; Preparation; Reporting; Research; Research Project Grants; Resources; Techniques; Technology; Vaccines; Vibrio cholerae; cost effective; data management; enterotoxigenic Escherichia coli; experience; instrumentation; microbiome; pathogen; prevent; vaccine development

Immune responses are of paramount importance in protection from infectious diseases and vaccines are an exceedingly cost-effective measure to prevent these illnesses. Despite considerable progress, the immunological correlates of protection from enteric infections and malaria, as well as other infectious agents that form part of this Ul 9 application remain unknown. To address these major gaps in knowledge, we will establish an Immunology Core that will generate unique immunological data to be correlated with microbiome, P. falciparum, V. cholerae, ETEC and other unique sequencing data resulting from studies proposed in this U19 application to address unexplored and critical new aspects of host-parasite interactions. The PI of this Immunology Core and his team are extremely experienced in the study of immune responses to infectious agents and vaccine development in humans and animal models using state-of-the-art techniques and instrumentation.

免疫反应对于预防传染病至关重要，而疫苗是一种重要手段 预防这些疾病的极其具有成本效益的措施。尽管取得了相当大的进展， 预防肠道感染和疟疾以及其他传染源的免疫相关性 构成此 Ul 9 应用程序一部分的内容仍然未知。为了解决这些主要的知识差距，我们将 建立免疫学核心，该核心将生成与相关的独特免疫学数据 微生物组、恶性疟原虫、霍乱弧菌、ETEC 和其他研究产生的独特测序数据 在此 U19 申请中提出，旨在解决宿主 - 寄生虫相互作用的未探索和关键的新方面。 该免疫学核心的 PI 及其团队在免疫反应研究方面经验丰富 使用最先进的技术在人类和动物模型中进行传染性病原体和疫苗开发 技术和仪器。