Neonatal Esophagus and Airway Interaction in Health and Disease

新生儿食道和气道在健康和疾病中的相互作用

• 批准号: 8742109
• 负责人: Sudarshan R Jadcherla
• 金额: $ 38.39万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-15 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8742109
• 关键词: Accounting; Acids; Address; Admission activity; Age-Months; Biological Markers; Bolus Infusion; Caring; Characteristics; Chronic; Clinical; Complex; Data; Deglutition; Deglutition Disorders; Diagnostic; Dietetics; Disease; Economic Burden; Economics; Effectiveness; Electrocardiogram; Esophageal; Esophagus; Fluoroscopy; Functional disorder; Future; Gagging; Gastroesophageal reflux disease; Goals; Growth; Health; Healthcare; Hospitalization; Impairment; Infant; Inferior esophageal sphincter structure; Innovative Therapy; Instruction; Intake; Knowledge; Larynx; Length of Stay; Manometry; Medical; Modification; Morbidity - disease rate; Motor; Multicenter Trials; Neonatal; Normalcy; Operative Surgical Procedures; Oral; Outcome; Parents; Penetration; Peristalsis; Pharyngeal structure; Physiology; Plethysmography; Population; Premature Infant; Program Research Project Grants; Pulse Oximetry; Quality of life; Randomized Controlled Trials; Reflex action; Reflux; Resolution; Safety; Sensory; Subgroup; Term Birth; Testing; Therapeutic; Therapeutic Intervention; Time; Upper Esophageal Sphincter; Viscosity; base; care burden; economic outcome; electric impedance; feeding; improved; indexing; innovation; migration; novel; novel diagnostics; respiratory; restoration; standard of care; success

In the infant population, the complex issues of dysphagia and swallowing remain to be a conundrum when it comes to the care management of this population. The lack of a pathophysiology guided diagnostic and safe feeding management strategies continue to be critical barriers to progress in this field. This proposal will focus on the dynamic changes in the integrative physiology of the neonatal pharynx, upper esophageal sphincter (UES), lower esophageal sphincter (LES) and esophagus during swallowing and GERD. The overall goal of this project is to examine new management approaches of dysphagia in the infant population. This project will address two aims. Aim 1: Effectiveness of two feeding strategies on clinical-, safety- and economic- outcomes in dysphagic infants with anterograde aspiration. The goal of this Aim is to develop novel feeding strategies, to improve clinical outcomes and to clarify aerodigestive protective mechanisms in oral-fed infants (under 6 months of age) with abnormalities proven by diagnostic video fluroscopy swallow study (VFSS). Aim 2: Mechanisms and Impact of feeding strategies on pharyngeal and esophageal sensitivity of aerodigestive reflexes in dysphagia with or without GERD. The goal of this Aim is to differentiate GERD and its consequences by examining the sensory-motor characteristics of the swallow, various reflexes and aero-digestive coordination using manometric studies.

在婴儿群体中，吞咽困难和吞咽的复杂问题仍然是一个难题。 涉及到这一人群的护理管理。缺乏病理生理学指导的诊断和安全 饲养管理策略仍然是该领域取得进展的关键障碍。该提案将 关注新生儿咽、食管上段综合生理的动态变化 吞咽过程中的括约肌 (UES)、下食管括约肌 (LES) 和食管以及 GERD。这 该项目的总体目标是研究婴儿吞咽困难的新管理方法。 该项目将实现两个目标。 目标 1：两种喂养策略对吞咽困难患者的临床、安全性和经济结果的有效性 顺行误吸的婴儿。 该目标的目标是开发新的喂养策略，改善临床结果并澄清 已证实存在异常的经口喂养婴儿（6 个月以下）的呼吸消化保护机制 通过诊断视频透视吞咽研究 (VFSS)。 目标 2：喂养策略对咽部和食管敏感性的机制和影响 伴有或不伴有 GERD 的吞咽困难的呼吸消化反射。 该目标的目标是通过检查感觉运动来区分 GERD 及其后果 使用测压研究来了解吞咽的特征、各种反射和呼吸消化协调。