Bioinformatics Core

生物信息学核心

• 批准号: 9250077
• 负责人: Purveshkumar Khatri
• 金额: $ 12.6万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9250077
• 关键词: Address; Bioinformatics; Biological; Cohort Analysis; Collaborations; Computer Simulation; Data; Data Set; Databases; Dependency; Disease; Elements; Funding; Gene Expression; Gene Expression Profiling; Genomics; Goals; Human; Immune; Immunologic Monitoring; Individual; Infection; Influenza vaccination; Informatics; Instruction; Internet; Lead; Measures; Medicine; Memory; Methods; Modality; National Institute of Allergy and Infectious Disease; Natural Immunity; Pathway interactions; Publishing; Statistical Data Interpretation; Techniques; Testing; Universities; Vaccination; Validation; Work; adaptive immune response; adaptive immunity; clinical phenotype; cohort; differential expression; improved; professor; repository; tool; transcription factor

The overall goal of the Bioinformatics Core is to use advanced bioinformatics tools for identification and improved understanding of the innate and adaptive immune response in vaccination and diseases. The Bioinformatics Core will utilize existing informatics platforms, and adapt them as needed, to achieve these goals. The goals of the Bioinformatics Core will (1) provide robust bioinformatics methods to analyze the data generated by Projects 1, 2 and 3, (2) serve data to the Projects for hypothesis testing, and (3) publish the data for public availability in repositories including the NIAID-funded ImmPort, and the NCBI Gene Expression Omnibus (GEO). The Bioinformatics Core will directly work with all Projects to address their need for robust bioinformatics techniques. The Bioinformatics Core will create a central repository of the genomic and immune profiling data, generated by all Projects, and integrate with genomic and immune profiling data from public repositories, to enable multi-cohort integrated analysis. Furthermore, the Bioinformatics Core will work closely with the Genomics Core and the Human Immune Monitoring Center (HIMC) for this purpose. This will enable participating Projects to maximally utilize the genomic, immune monitoring and clinical phenotypic data sets to determine functional dependencies among the measured elements and to direct further biological validation of these putative dependencies.

生物信息学核心的总体目标是使用高级生物信息学工具进行识别和 对疫苗接种和疾病中先天和适应性免疫反应的了解得以提高。这 生物信息学核心将利用现有的信息学平台，并根据需要调整它们来实现这些平台 目标。生物信息学核心的目标将（1）提供强大的生物信息学方法来分析 项目1、2和3，（2）生成的数据将数据提供给项目的假设测试，以及（3）发布 包括NIAID资助的Immport和NCBI基因在内的存储库中公共可用性的数据 表达综合（GEO）。 生物信息学核心将直接与所有项目合作，以满足其对强大生物信息学的需求 技术。生物信息学核心将创建基因组和免疫分析的中央存储库 数据，由所有项目生成，并与公众的基因组和免疫分析数据集成 存储库，以实现多核心综合分析。此外，生物信息学核心将起作用 为此，与基因组核心和人类免疫监测中心（HIMC）紧密相关。这会 使参与的项目能够最大程度地利用基因组，免​​疫监测和临床表型 数据集以确定测量元素之间的功能依赖性，并向进一步指导 这些推定依赖性的生物学验证。