Training in Reproductive Sciences

生殖科学培训

• 批准号: 9385648
• 负责人: PAMELA L MELLON
• 金额: $ 0.68万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-01 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9385648
• 关键词: Science; Training; reproductive

DESCRIPTION (provided by applicant): The urgency and importance of producing critically needed basic, translational, and clinical scientists in the area of women's health and reproduction is well recognized by the leadership of NIH, the scientific community, the national government, and the society as a whole. The UCSD T32 Training Program in Reproductive Sciences takes a unique multidisciplinary approach to the training of postdoctoral scholars as physician- scientists and reproductive biologists in the field of neuroendocrine and endocrine control of reproductive processes. The combination of clinical, physiological, and molecular approaches to reproductive biology and medicine creates an exceptional opportunity for the training of physician-scientists and basic scientists, as well- rounded reproductive endocrinologists who become extraordinarily qualified for academic careers. The program supports both fellows seeking advanced basic/translational research experience after the Ph.D. and/or M.D. degree, and those seeking clinical and research training with the aim of becoming board-certified in Reproductive Endocrinology and Infertility and continuing in academic clinical research. We have an outstanding 30-year track record as recognized by an NIH MENTOR AWARD that extended the program for 10 years from 2003-2012. A cohesive group of NIH-funded faculty from the Division of Reproductive Endocrinology in the Department of Reproductive Medicine and the Division of Endocrinology in the Department of Medicine at UCSD with common interests, shared grants, joint publications, and complimentary backgrounds, provides basic, translational, and clinical training and fosters the success and careers of the trainees. All faculty are members of the UCSD NICHD U54 Specialized Cooperative Centers Program in Reproductive and Infertility Research and all of the senior faculty members are mentors in the UCSD NICHD K12 Women's Reproductive Health Research Program for the training of OB/GYN junior faculty in research careers. Thus, this training program is integrated with both NICHD Centers, allowing the faculty and fellows to interact at many levels, creating an atmosphere of cooperation, collaboration, mentoring, and career support. Our research activities range from molecular to patient-oriented research utilizing models from in vitro analysis and cell culture, to whole animal and clinical research. Major foci of investigation include: gonadal, pituitary and hypothalamic development, ovarian physiology, polycystic ovary disease, signal transduction, Kisspeptin, NeurokininB, GnRH, and gonadotropin gene expression and secretion, metabolic impact on reproductive function, and activin and growth factors in reproduction. The program of training for the fellows includes group meetings and presentations, journal clubs, seminars, national meetings, clinical activity and training, laboratory training, independent research, grantsmanship training, and coursework in molecular biology, neuroendocrinology, bio- statistics, and ethics, and an innovative "Thesis Committee" mentoring structure. Our aim is to prepare outstanding physician-scientists and basic scientists to become the future leaders in academic reproductive research.

描述（由申请人提供）：NIH、科学界、国家政府和社会的领导层充分认识到培养妇女健康和生殖领域急需的基础科学家、转化科学家和临床科学家的紧迫性和重要性作为一个整体。加州大学圣地亚哥分校 T32 生殖科学培训项目采用独特的多学科方法，在生殖过程的神经内分泌和内分泌控制领域培训作为医师科学家和生殖生物学家的博士后学者。生殖生物学和医学的临床、生理和分子方法的结合为培养医师科学家和基础科学家以及成为具有学术职业资格的全面的生殖内分泌学家创造了绝佳的机会。该计划支持两位研究员在获得博士学位后寻求先进的基础/转化研究经验。和/或医学博士学位，以及那些寻求临床和研究培训的人，其目的是获得生殖内分泌学和不孕不育方面的委员会认证，并继续从事学术临床研究。我们拥有 30 年的杰出业绩记录，并获得 NIH 导师奖的认可，该奖将该计划从 2003 年至 2012 年延长了 10 年。由 NIH 资助的生殖医学系生殖内分泌学系和 UCSD 医学系内分泌学系的教师组成的一个有凝聚力的团队，拥有共同的兴趣、共享资助、联合出版物和互补的背景，提供基本的、翻译性的和临床培训，促进学员的成功和职业生涯。所有教员都是 UCSD NICHD U54 生殖和不孕不育研究专业合作中心项目的成员，所有高级教员都是 UCSD NICHD K12 妇女生殖健康研究项目的导师，该项目旨在培训妇产科初级教员的研究职业。因此，该培训计划与 NICHD 两个中心相结合，使教师和研究员能够在多个层面上互动，营造合作、协作、指导和职业支持的氛围。我们的研究活动范围从分子研究到以患者为导向的研究，利用体外分析和细胞培养的模型，到整体动物和临床研究。主要研究重点包括：性腺、垂体和下丘脑发育、卵巢生理学、多囊卵巢病、信号转导、Kisspeptin、NeurokininB、GnRH 和促性腺激素基因表达和分泌、代谢对生殖功能的影响以及生殖中的激活素和生长因子。研究员的培训计划包括小组会议和演讲、期刊俱乐部、研讨会、全国会议、临床活动和培训、实验室培训、独立研究、资助培训以及分子生物学、神经内分泌学、生物统计学和伦理学课程。以及创新的“论文委员会”指导结构。我们的目标是培养杰出的医学科学家和基础科学家，成为学术生殖研究的未来领导者。