Center for Reproductive Science and Medicine

生殖科学与医学中心

• 批准号: 8079991
• 负责人: PAMELA L MELLON
• 金额: $ 13万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8079991
• 关键词: Activins; Address; Androgens; Anovulation; Award; Basic Science; Cells; Center for Translational Science Activities; Clinical; Clinical Medicine; Disease; Female infertility; Female of child bearing age; Fertility; Funding; Genetic Transcription; Goals; Gonadotrope Cell; Hormonal; Hormones; Human; Hypothalamic structure; In Vitro; Infertility; Instruction; Insulin Resistance; Lead; Medicine; Metabolic; Metabolic Control; Modeling; Molecular; Mus; Neurons; New Territories; Obesity; Ovarian; Ovary; Paper; Patients; Pituitary Diseases; Pituitary Gland; Pituitary Hormones; Polycystic Ovary Syndrome; Precocious Puberty; Production; Productivity; Publishing; Regulation; Relative (related person); Reproduction; Research Personnel; Research Project Grants; Role; Science; System; Tissue Banking; Tissue Banks; Tissues; Translations; Woman; adiponectin; experience; hormone regulation; human disease; hypothalamic pituitary ovarian axis; improved; in vivo; innovation; mouse model; multidisciplinary; novel; programs; reproductive; reproductive function; steroid hormone; theca cell

PROJECT SUMMARY (See instructions): The goal of the Center for Reproductive Science and Medicine at UCSD is to develop understanding of the mechanisms that govern normal and disordered function of the hypothalamic-pituitary-ovarian axis. This application represents our renewal for years 29-33. Our productivity has been outstanding with 60 papers published and 9 submitted in 3 years of a 4-year award. We will continue to produce novel, significant contributions to the reproductive sciences, integrating multidisciplinary clinical, translational, and basic research to facilitate and accelerate the translation of promising new discoveries into clinical medicine. We are proposing 3 integrated, innovative Research Projects, all with experienced, internationally renowned leaders. Project I (Pamela L. Mellon, PL) will address the hormonal control of the pituitary gonadotrope, focusing on regulation by activin, GnRH, and steroid hormones in vitro and in vivo. The emphasis will be on understanding the synergy and interdependence between these hormones in controlling transcription in model immortalized gonadotrope cells, genetically modified mice, and mouse models of precocious puberty and PCOS. Project II (Jerrold M. Olefsky, PL) will chart new territory in the role of metabolic control in fertility. A dual in vivo/in vitro approach will elucidate the mechanisms of adiponectin, SirT1, and PPARy actions in regulating reproduction, using immortalized hypothalamic GnRH-secreting neurons and gonadotrope cells, novel genetically modified mice, and mouse models of PCOS. Project III (R. Jeffrey Chang, PL) will delineate the relative roles of specific factors implicated in excess production of androgen by the ovarian theca cell in women with PCOS and undertake studies in human ovary culture systems, addressing fundamental mechanisms underlying PCOS. All Project Leaders serve as Co-l's on other components of the Center and all 3 projects include teams of very experienced investigators. The Projects are highly interactive and synergistic, creating a coherent mechanistic and translational Center. The Administrative Core supports the Center, provides the Enrichment Program, and facilitates interactions within the Center and the SCCPIR Program. The SCCPIR Human Ovary Tissue Bank provides tissue to NIH-funded investigators nation-wide.

项目摘要（请参阅说明）： UCSD生殖科学和医学中心的目标是对管理下丘脑垂体 - 垂体轴的正常功能的机制发展理解。该申请代表了我们在29 - 33年的续签。我们的生产力非常出色，有60篇论文 出版和9份在4年奖励的3年中提交。我们将继续为生殖科学产生新颖的贡献，将多学科的临床，转化和基础研究整合在一起，以促进和加速有希望的新发现向临床医学的翻译。我们提出了3个综合，创新的研究项目，所有研究项目都有经验丰富的国际知名领导人。项目I（Pamela L. Mellon，PL）将解决垂体性促性腺促性腺瘤的激素控制，重点介绍了Activin，GnRH和类固醇激素的调节，并在体内和体内进行调节。重点是理解这些激素在控制转录中的协同作用和相互依赖性 模型永生的促性腺细胞，转基因的小鼠以及早熟的青春期和PCOS的小鼠模型。 II项目（Jerrold M. Olefsky，PL）将在代谢控制中的作用中绘制新领域。 双重体内/体外方法将使用永生的下丘脑GNRH神经元和促性腺粒细胞，新的基因遗传化的小鼠以及PCOS的小鼠模型，阐明脂联素，SIRT1和PPARY在调节繁殖方面的机制。 III项目（R. Jeffrey Chang，PL）将划定 特定因素的相对作用在患有PCOS的女性并在人类卵巢培养系统中进行研究中涉及雄激素过量产生雄激素的相对作用，以解决PCOS的基本机制。所有项目负责人都担任该中心其他组件的共同体，所有3个项目均包括经验丰富的调查员团队。这些项目具有高度互动性，并且 协同作用，创建一个连贯的机械和转化中心。行政核心支持该中心，提供丰富计划，并促进中心和SCCPIR计划中的互动。 Sccpir人卵巢组织库为全国NIH资助的研究人员提供组织。