Advanced virtual simulator for real-time ultrasound-guided renal biopsy training

用于实时超声引导肾活检训练的先进虚拟模拟器

• 批准号: 9408987
• 负责人: Andinet Asmamaw Enquobahrie
• 金额: $ 22.5万
• 依托单位: KITWARE, INC.
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-18 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9408987
• 关键词: Acute Renal Failure with Renal Papillary Necrosis; Area; Atlases; Biopsy; Biopsy Specimen; Cells; Child; Childhood; Chronic Kidney Failure; Clinical; Clinical Management; Collaborations; Competence; Complex; Computer software; Development; Devices; Diagnostic; Dimensions; Disease; Double-Blind Method; Ensure; Environment; Evaluation; Face; Feedback; Funding Opportunities; Goals; Home environment; Human; Image Guided Biopsy; Institutes; Institution; International; Intervention; Interventional radiology; Kidney; Kidney Neoplasms; Laboratories; Lead; Manikins; Manuals; Measures; Medical; Medical center; Methods; Modeling; Molecular Genetics; Morbidity - disease rate; Needle biopsy procedure; Needles; Operative Surgical Procedures; Outcome; Participant; Pathology; Pathway interactions; Pediatric Hospitals; Pediatric Radiologist; Performance; Phase; Physics; Procedures; Research; Resources; Risk; Safety; Small Business Innovation Research Grant; Specimen; Staging; Subgroup; System; Systems Development; Tactile; Techniques; Technology; Testing; Time; Tissues; Training; Tumor Tissue; Ultrasonography; Validation; Work; apprenticeship; base; clinical translation; design; dexterity; experience; field study; frontier; genetic information; haptics; image guided intervention; improved; innovation; mortality; new technology; new therapeutic target; open source; outcome forecast; precision medicine; prototype; radiologist; response; simulation; simulation software; skills; skills training; technology development; technology validation; tool; tumor; validation studies; virtual

ABSTRACT The objectives of the Kidney Precision Medicine Project (KPMP) project are to create a kidney tissue atlas, define disease subgroups, and identify critical cells, pathways and targets for novel therapies by obtaining and evaluating kidney biopsies from participants with acute kidney injury (AKI) and chronic kidney disease (CKD). As part of this effort, there is a need for new technologies that improve the safety of the human kidney biopsy as well as the quality and diagnostic yield so that the biopsy tissue yields useful research or clinical information. Ultrasound-guided kidney biopsy is a critically important tool in the evaluation and management of renal pathologies. The goal of this Phase I SBIR proposal is to develop a virtual simulator to train clinicians to improve procedural skill competence in real-time ultrasound-guided renal biopsy. Although improvements in needle design and ultrasound imaging have been helpful, excellent biopsy technique and skill are essential to consistently obtaining high yield renal biopsy samples. Furthermore, poor renal biopsy technique can potentially lead to significant complications and adverse lethal outcomes. The simulator proposed in this project will accelerate the training of ultrasound-guided renal biopsy in a risk-free environment, ultimately improving the safety of kidney biopsy and ensuring that the biopsy procedure yields high quality specimen that can provide useful clinical information. The proposed system will benefit radiologists, nephrologists, and interventional radiologists in two ways: (a) Improved three dimensional and dynamic ultrasound imaging interpretation specific to performing a needle biopsy and (b) Improved manual dexterity in needle handling with the aid of tactile feedback. This project is a collaboration between Kitware Inc. and Children's National Medical Center. Kitware is a leader in the creation and support of state-of-the-art software and technology with more than 15 years of experience in image-guided interventions. Children's National Medical Center (CNMC) is an internationally recognized pediatric hospital with extensive expertise in the clinical management of renal pathologies. The two institutions have already collaborated successfully on several projects including image guided biopsy projects. The aims of the Phase I project are to build the virtual simulator system and evaluate it by conducting a study with pediatric radiologists, nephrologists, and interventional radiologists at CNMC. The successful completion of the Phase I work will result in a proof of concept of our simulator system and lay the groundwork for further system development and validation in Phase II.

抽象的 肾脏精准医学项目 (KPMP) 项目的目标是创建一个 肾组织图谱，定义疾病亚组，并确定关键细胞、途径和靶点 通过获取和评估患有急性肾病的参与者的肾活检来寻找新疗法 肾损伤（AKI）和慢性肾病（CKD）。作为这项努力的一部分，需要 提高人体肾活检安全性以及质量和质量的新技术 诊断率，以便活检组织产生有用的研究或临床信息。 超声引导下的肾活检是评估和管理中至关重要的工具 肾脏病理学。第一阶段 SBIR 提案的目标是开发一个虚拟模拟器 培训临床医生提高实时超声引导肾病的操作技能 活检。 尽管针设计和超声成像的改进有所帮助， 卓越的活检技术和技能对于持续获得高产量肾至关重要 活检样本。此外，不良的肾活检技术可能会导致严重的后果。 并发症和不良致死结果。本项目中提出的模拟器将 最终在无风险的环境中加速超声引导肾活检的培训 提高肾活检的安全性并确保活检程序的高质量 可以提供有用的临床信息的标本。 拟议的系统将使放射科医生、肾脏科医生和介入科医生受益 放射科医生可以通过两种方式： (a) 改进三维和动态超声成像 (b) 提高​​针吸活检的操作灵活性 借助触觉反馈进行针处理。该项目是 Kitware 之间的合作 公司和国家儿童医疗中心。 Kitware 是创建和支持以下领域的领导者 最先进的软件和技术，在图像引导方面拥有超过 15 年的经验 干预措施。国家儿童医疗中心 (CNMC) 是国际公认的 儿科医院在肾脏病理临床管理方面拥有丰富的专业知识。这 两个机构已经在多个项目上成功合作，包括图像 引导活检项目。一期项目的目标是构建虚拟模拟器系统 并通过与儿科放射科医生、肾脏科医生和儿科放射科医生进行研究来评估它 CNMC 介入放射科医生。第一阶段工作的顺利完成将导致 我们的模拟器系统的概念证明，并为进一步的系统奠定基础 第二阶段的开发和验证。

项目成果

Towards an Advanced Virtual Ultrasound-guided Renal Biopsy Trainer.

迈向先进的虚拟超声引导肾活检训练器。

• DOI: 10.1117/12.2512871
• 发表时间: 2019
• 期刊: Proceedings of SPIE--the International Society for Optical Engineering
• 作者: Horvath,Samantha;Arikatla,Sreekanth;Cleary,Kevin;Sharma,Karun;Rosenberg,Avi;Enquobahrie,Andinet
• 通讯作者: Enquobahrie,Andinet