Cross-national Analysis of Alcohol and Injury

酒精和伤害的跨国分析

• 批准号: 9249434
• 负责人: CHERYL J CHERPITEL
• 金额: $ 41.51万
• 依托单位: PUBLIC HEALTH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9249434
• 关键词: Accident and Emergency department; Acute; Address; Advertising; Affect; Alcohol consumption; Alcoholic Beverages; Alcohols; American; Area; Australia; Automobile Driving; Burn injury; Characteristics; Communities; Community Actions; Consumption; Country; Coupled; Data; Data Set; Dose; Economic Development; Emergency Department patient; Environment; Event; Gap Junctions; General Population; Grant; Guidelines; Health Professional; Hour; Individual; Injury; Intervention; Intramural Research Program; Label; Laws; Linear Models; Literature; Marketing; Methodology; Modeling; Morbidity - disease rate; National Institute on Alcohol Abuse and Alcoholism; Near Drowning; Organization and Administration; Pan American Health Organization; Patient Self-Report; Patients; Pattern; Poisoning; Policies; Population Attributable Risks; Prevention strategy; Price; Privatization; Probability Samples; Public Health; Relative Risks; Research; Risk; Self-Injurious Behavior; Services; Site; Suicide attempt; Testing; Violence; Work; World Health; World Health Organization; alcohol availability; alcohol epidemiology; alcohol research; alcohol risk; alcohol-related injury; base; burden of illness; data archive; drinking; drinking behavior; economic cost; falls; injured; instrumentation; intimate partner violence; knowledge base; public health relevance; public policy on alcohol; response; social; trauma centers

DESCRIPTION (provided by applicant): This competing continuation builds on and extends research which analyzed ER data from the 12-site WHO Collaborative Study on Alcohol and Injuries, 33 sites in 8 countries comprising the Emergency Room Collaborative Alcohol Analysis Project (ERCAAP), and 30 sites in 13 countries added in the previous project period, data from studies all of which used similar methodology and instrumentation on probability samples of ER patients. Study aims are to: 1) examine risk of alcohol-related injury for self-reported consumption within 6 hours prior to all-cause injury and by injury cause (traffic, falls, intimate partner violence, other violence, burns, near drowning, poisoning, attempted suicide) by country/region level drinking patterns, context of drinking, alcohol control policy, and ER-level characteristics; 2) estimate relative risk (RR) of injury related to alcohol consumption volume (dose-response relationship) by cause of injury, comparing estimates with and without adjusting for individual-level injury context, and comparing estimates across regions of varying aggregate level detrimental drinking pattern (DDP), drinking context and alcohol policies; 3) estimate alcohol attributable fraction (AAF) by cause of injury, combining ER data and general population (GP) data, applying ER-based RR of injury related to drinking and predicted acute drinking exposure based on both individual-level and GP usual drinking pattern data. Aims address objectives of the Global Strategy to Reduce the Harmful Use of Alcohol, endorsed by the World Health Assembly in May 2010, in strengthening the knowledge base on the magnitude and determinants of alcohol-related harm, and, among other aims, will inform five of their 10 recommended policy target areas: community action, drinking-driving, alcohol availability, marketing of alcoholic beverages and pricing. Data will be added on 21,007 patients from 44 ER sites in 16 countries, cumulating in 43,453 injured patients from 119 ER sites covering 37 countries. Hierarchical linear modeling and case-crossover analysis and will examine contextual variables, including alcohol policy with individual and event-level variables on the alcohol-injury nexus, addressing a major gap in this literature. Coupled with GP data, this data set is one of a kind in providing the requisite number of patients to analyze specific alcohol policy control domains and variables in relation to specific causes of injury, adjust bias in RR of injury related to context of the event, and apply a new ER-based approach to estimating AAF by injury cause, based on both ER and GP drinking pattern data, which has the potential for extrapolation to countries with similar profiles (e.g., per capita consumption, DDP), for which ER studies are not available but GP pattern data are, and for GPs for which there are no exposure data, but where demographic and archival data are available. This work will, importantly, inform U.S. policy, potentially leading to policy change, as the U.S. is composed of many micro-cultures reflected in the contextual environment dominating many of the countries in which these data were collected.

DESCRIPTION (provided by applicant): This competing continuation builds on and extends research which analyzed ER data from the 12-site WHO Collaborative Study on Alcohol and Injuries, 33 sites in 8 countries comprising the Emergency Room Collaborative Alcohol Analysis Project (ERCAAP), and 30 sites in 13 countries added in the previous project period, data from studies all of which used similar methodology and instrumentation on probability samples of ER patients.研究的目的是：1）检查全因受伤前6小时内自我报告的损伤的风险，以及受伤原因（交通，跌倒，亲密伴侣暴力，其他暴力，烧伤，近乎溺水，溺水，溺水，未遂自杀），按地区/地区级2）估计与饮酒量（剂量反应关系）相关的损伤的相对风险（RR），通过伤害的原因，比较或不调整个体水平损伤环境的估计值，并比较各个不同总体有害饮酒模式（DDP）的估计值（DDP），饮酒环境和酒精政策； 3）根据受伤原因估计酒精归因于可归因于饮酒的原因（AAF），将基于ER的损伤施加了与饮酒和预测急性饮酒有关的基于ER的RR，并基于个人级别和GP通常的饮酒模式数据。目的是解决全球战略的目标，以减少2010年5月世界卫生大会的有害使用，以加强与酒精相关危害的规模和决定因素的知识基础，除其他目的外，还将告知其10个推荐的政策目标中的5个：社区行动，饮酒，酒精饮酒，酒精饮酒，酒精饮料，酒精饮料和pric饮料。将添加来自16个国家 /地区44个ER部位的21,007名患者的数据，其中43,453名受伤的患者来自119个涉及37个国家的ER部位。分层线性建模和案例分解分析，并将检查上下文变量，包括对酒精侵害的个人和事件级变量的酒精政策 Nexus，解决了本文中的主要差距。加上GP数据，该数据集是提供必要数量的患者来分析特定酒精策略控制域和变量与特定伤害原因，调整与损伤相关的RR的偏差的一种患者之一 to context of the event, and apply a new ER-based approach to estimating AAF by injury cause, based on both ER and GP drinking pattern data, which has the potential for extrapolation to countries with similar profiles (e.g., per capita consumption, DDP), for which ER studies are not available but GP pattern data are, and for GPs for which there are no exposure data, but where demographic and archival data are available.重要的是，这项工作将为美国政策提供信息，可能导致政策变化，因为美国由许多微文化组成，这些微文化在上下文环境中反映了许多占主导地位的数据，这些国家收集了这些数据的许多国家。