Image Data Acquisition, Analysis, and Modeling Core

图像数据采集、分析和建模核心

基本信息

批准号：
9275044
负责人：
SHENG-KWEI SONG
金额：
$ 20.44万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-25 至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/9275044
关键词：
Acute Address Affect Agar Animal Model Animals Autopsy Axonal Transport Back Biological Markers Biopsy Blood - brain barrier anatomy Brain Cell Polarity Cells Cellularity Central Nervous System Diseases Chronic Clinical Trials Communities Computer software Conflict (Psychology)Data Data Analyses Decision Making Demyelinations Development Diagnostic Diffusion Diffusion Magnetic Resonance Imaging Disease Edema Endothelial Cells Ensure Experimental Autoimmune Encephalomyelitis Experimental Designs Extravasation Funding Gel Gold Histologic Histology Human Human Resources Image Immunohistochemistry Impairment Individual Infiltration Inflammation Magnetic Resonance Imaging Manganese Manuals Maps Measurement Measures Methods Modeling Multiple Sclerosis Multiple Sclerosis Lesions Mus Myelin Myelin Sheath Neuraxis Optic Nerve Outcome Measure Pathogenesis Pathology Patient Monitoring Patients Procedures Program Research Project Grants Protocols documentation Readability Regulation Reporting Resolution Sampling Services Signal Transduction Spinal Cord Staining method Stains Statistical Data Interpretation Supervision Testing Time Tissues Translating Treatment Efficacy Validation Visual Acuity Water Work axon injury data acquisition data management design head-to-head comparison human subject imaging biomarker imaging modality imaging study improved in vivo in vivo imaging member multiple sclerosis patient neuropathology novel therapeutics prevent professor spectrograph success tissue phantom tool white matter white matter injury

项目摘要

Objectives: The Image Data Acquisition, Analysis, and Modeling Core will be responsible for (1) supporting the MRI experimental design and execution for all projects; (2) developing an objective MRIimmunohistochemistry validation method; (3) improving data acquisition efficiency; (4) streamlining postprocessing procedures; and (5) participating in data interpretation and dissemination of all MRI results. Core C will explore the possibility of using T2 relaxometry, myelin water imaging, to detect and quantify multiple pathologies in CNS white matter. Core Services: Core C is specifically designed to support all Projects of this program project grant, not a general purposed service core unit to the community. Outside studies relevant to the scope of this PPG will be considered after the approval of Executive Committee (Drs. Cross, Klein, Song and Trinkaus). It is the responsibility of Core C to perform all necessary tasks assuring the success of all MRI measurements. Decision-Making: During the planning of this renewal of this PPG, members of the executive committee have met and discussed regularly on specific tasks of Core C. Thus, the Core Co-directors Song and Kim will work closely with all Project and Core personnel to perform the proposed MRI studies and modify if necessary as projects progress. Any conflict in experimental execution will first be resolved between the involved Project/Core directors and Song/Kim team. Any unresolved conflict will be resolved through the PPG Executive Committee. The data interpretation and dissemination will be conducted by all involved Project/Core personnel, submitting to Executive Committee for final approval.

目标：图像数据采集，分析和建模核心将负责（1）支持所有项目的MRI实验设计和执行；（2）开发客观的MRIIMUNO组织化学验证方法；（3）提高数据采集效率；（4）简化后处理程序；（5）参与所有MRI结果的数据解释和传播。核 C将探索使用T2松弛测定法，髓磷脂水成像的可能性，以检测和量化多个中枢神经系统白质的病理。核心服务：核心C专门设计用于支持该计划项目赠款的所有项目，而不是社区的一般目的服务核心单位。与此PPG范围相关的外部研究将在执行委员会批准后考虑（克罗斯博士，克莱因，宋和特林科斯）。是 Core C执行所有必要任务的责任确保所有MRI测量的成功。决策：执行委员会成员在此PPG的续约计划期间已经定期就核心C的特定任务进行了遇到并讨论。因此，核心联合导演歌曲和Kim 将与所有项目和核心人员紧密合作，以执行拟议的MRI研究并修改是否随着项目的进展而有必要。实验执行中的任何冲突将首先解决涉及项目/核心导演和歌曲/KIM团队。任何未解决的冲突将通过 PPG执行委员会。数据解释和传播将由所有涉及的所有项目/核心人员，向执行委员会提交最终批准。