Colorado PETAL Clinical Center

科罗拉多州 PETAL 临床中心

基本信息

批准号：
9268040
负责人：
Adit A. Ginde
金额：
$ 37.39万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-06-17 至 2021-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9268040
关键词：
Accident and Emergency department Acute Acute Lung Injury Address Admission activity Adult Respiratory Distress Syndrome Affect Alaska Native Ally American Indians Area Bilateral Caring Case Series Chest Clinical Clinical Medicine Clinical Research Clinical Trials Collaborations Colorado Conduct Clinical Trials Consent Country Critical Care Critical Illness Data Development Early treatment Emergency Medicine Emergency department visit Enrollment Extramural Activities Fostering Funding Goals Growth Health Hispanics Hospitals Hypoxemia Individual Injury Institutional Review Boards Intensive Care Units Intervention Lead Liquid substance Lung Manuscripts Mechanics Medical center Medicine Methodology Methods Mosses Multi-Institutional Clinical Trial National Heart, Lung, and Blood Institute Operative Surgical Procedures Outcome Patient Care Patient-Focused Outcomes Patients Pneumonia Positioning Attribute Prevention Prevention trial Principal Investigator Process Protocol Compliance Protocols documentation Publications Publishing Pulmonary Embolism Recording of previous events Research Research Infrastructure Research Personnel Research Project Grants Residencies Resources Risk Rosa Sampling Science Seminal Sepsis Site Symptoms Syndrome Testing Time Training Programs Transfusion United States Universities Work base clinical care clinical infrastructure data acquisition experience improved improved outcome innovation medical specialties member metropolitan multidisciplinary patient oriented research prevent public health relevance research study screening

项目摘要

DESCRIPTION (provided by applicant): Almost 50 years ago, Dr. Tom Petty and his surgical colleagues identified 12 patients at the University of Colorado with similar clinical symptoms: severe hypoxemia, bilateral infiltrates on chest radiograph, and diminished static pulmonary compliance. The clinical features of these patients were published as a case series in the Lancet and serve as the initial description of the acute respiratory distress syndrome (ARDS). This seminal discovery launched a long and productive history of ARDS research in Denver. We have been a member of the ARDS Network since its inception in 1994. Our multi-disciplinary and collaborative critical care research group is experienced in conducting high quality multi-center clinical trials. As a result, we have always been one of the top enrolling ARDS Network sites for over 19 years. The University of Colorado's Department of Emergency Medicine was one of the first residency training programs in Emergency Medicine and remains one of most highly regarded training programs in the country. Their extramural funding has grown rapidly in the past decade especially in the area of critical care research. The Division of Pulmonary Sciences and Critical Care Medicine and the Department of Emergency Medicine have an established record of effective collaborations in both patient-oriented and research initiatives. Building on this ARDS Network research infrastructure, we will create an integrated Critical Care and Emergency Medicine clinical center to effectively conduct clinical trials for the prevention and early treatment of acute lung injury. This Colorado PETAL Clinical Center will exceed meet our enrollment obligations; maintain excellence in the quality of protocol compliance, data acquisition, and regulatory responsibilities; actively participate and contribute to the subsequent responsibilities of the steering and other PETAL committees; and contribute to the improved care of patients with and at risk for ARDS.

描述（由申请人提供）：大约50年前，汤姆·佩蒂（Tom Petty）博士和他的外科同事在科罗拉多大学发现了12例患者，患有相似的临床症状：严重的低氧血症，胸部X光片上的双侧浸润，静态肺合规性降低。这些患者的临床特征是在柳叶刀中发表的病例系列，并作为急性呼吸窘迫综合征（ARDS）的最初描述。这一开创性发现在丹佛创造了漫长而富有成效的ARDS研究历史。自1994年成立以来，我们一直是ARDS网络的成员。我们的多学科和协作重症监护研究小组在进行高质量的多中心临床试验方面经验丰富。结果，我们一直是19年以上最重要的ARDS网络网站之一。科罗拉多大学急诊医学系是急诊医学上最早的居住培训计划之一，仍然是该国最受欢迎的培训计划之一。在过去的十年中，尤其是在重症监护研究领域，他们的校外资金迅速增长。肺科学和重症监护医学和急诊医学系具有既定的有效合作记录，以患者为导向和研究计划。在此ARDS网络研究基础设施的基础上，我们将创建一个综合的重症监护和急诊医学临床中心，以有效地进行临床试验，以预防和早期治疗急性肺损伤。这个科罗拉多花瓣临床中心将超过我们的入学义务；在协议合规，数据获取和监管责任的质量方面保持卓越；积极参与并为随后的转向和其他花瓣委员会的责任；并有助于改善患有ARD的患者的护理。