Disability after ACL Reconstruction: Development of an Alternative Model of Care

ACL 重建后的残疾：替代护理模式的开发

基本信息

批准号：
9308429
负责人：
Laura C Schmitt
金额：
$ 15.81万
依托单位：
OHIO STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-06-01 至 2020-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9308429
关键词：
Address Adult Age Anterior Cruciate Ligament Attention Biomechanics Caring Cartilage Clinical Clinical Trials Data Data Set Degenerative polyarthritis Development Diagnostic radiologic examination Elderly Enrollment Evaluation Fibrinogen Frequencies Future Goals Health Care Costs Individual Injury Intervention Intervention Studies Joints Knee Knee Injuries Knee Osteoarthritis Knowledge Longevity Magnetic Resonance Imaging Medical Surveillance Mission Modeling Muscle function National Institute of Arthritis and Musculoskeletal and Skin Diseases Operative Surgical Procedures Outcome Outcome Study Pain Participant Patient Care Patient Outcomes Assessments Patient Self-Report Patients Physicians Population Positioning Attribute Prevention Prospective Studies Quality of life Reporting Risk Sex Behavior Surveillance Modeling Symptoms Testing Time United States Work anterior cruciate ligament reconstruction cartilage degradation clinical care cohort data registry design disability early onset functional decline functional disability high risk improved innovation joint destruction ligament injury multimodality muscle strength novel outcome prediction physical therapist premature public health relevance radiologist reconstruction standard care tool years lived with disability young adult

项目摘要

PROJECT SUMMARY Osteoarthritis (OA) is a leading cause of functional disability in the United States and worldwide. Premature development of knee OA is recognized with increasing frequency in young adults after anterior cruciate ligament (ACL) reconstruction (ACLR). As early as 7 to 15 years following reconstruction, a large majority of individuals develop knee OA, a major cause of pain, functional disability and decline in quality of life throughout the adult life-span. In line with the mission of the National Institute of Arthritis and Musculoskeletal and Skin Diseases, this proposal will advance knowledge into the causes, treatment, and prevention of knee OA and related disability after ACLR. The long-term objective of our team is to improve the current model of care for patients after ACLR. This prospective study will provide critical data needed to inform an effective future clinical trial. The proposed Aims incorporate multimodal testing of outcomes following ACLR. Through the proposed aims, we will obtain critical knowledge to guide our future clinical trial.

项目摘要骨关节炎（OA）是美国和全球功能残疾的主要原因。早产膝盖OA的发育均以前交叉后年轻人的频率越来越多韧带（ACL）重建（ACLR）。重建后7至15年，大部分大多个人发展膝盖OA，这是疼痛，功能残疾和生活质量下降的主要原因成人寿命。符合美国国家关节炎和肌肉骨骼和皮肤的任务疾病，该提案将使知识成为膝盖OA的原因，治疗和预防 ACLR后相关的残疾。我们团队的长期目标是改善当前的护理模式 ACLR后的患者。这项前瞻性研究将提供重要的数据，以告知有效的未来临床审判。拟议的目的纳入了ACLR后结果的多模式测试。通过拟议的目的，我们将获得关键知识，以指导我们未来的临床试验。