The Classification of Anxiety and Mood Disorders

焦虑和情绪障碍的分类

• 批准号: 9303450
• 负责人: Timothy A. Brown
• 金额: $ 71.44万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 1984
• 资助国家: 美国
• 起止时间: 1984-04-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9303450
• 关键词: Address; Anxiety; Anxiety Disorders; Behavioral Genetics; Biological; Blood; Boston; Candidate Disease Gene; Categories; Characteristics; Classification; Clinic; Clinical; Cognitive; Collaborations; Comorbidity; DNA; DSM-V; Data; Development; Diagnosis; Diagnostic; Dimensions; Disease; Elements; Emotional; Emotions; Etiology; Evaluation; Factor Analysis; Funding; Genetic; Genotype; Health; Institutes; Investigation; Laboratories; Life Stress; Longitudinal Studies; Measurement; Measures; Medical Genetics; Memory; Mental Depression; Mental disorders; Methodology; Methods; Modeling; Mood Disorders; Nature; Neurobiology; Neurotic Disorders; Neurotics; Panic Disorder; Patient Self-Report; Patients; Pattern; Personality; Pharmacology; Phase; Phenotype; Prevention; Progress Reports; Psychometrics; Psychopathology; Publications; Questionnaires; Research; Resources; Role; Saliva; Sampling; Scheme; Selection for Treatments; Series; Severities; Shapes; Specificity; Structural Models; Symptoms; System; Temperament; Time; Treatment Protocols; Universities; Validation; Virginia; Work; attentional bias; base; cognitive neuroscience; community based participatory research; distress tolerance; emotion dysregulation; emotion regulation; follow-up; foot; gene environment interaction; genetic analysis; genetic approach; genetic variant; genome wide association study; longitudinal course; novel; outcome forecast; phenomenological models; psychogenetics; psychologic; public health relevance; research clinical testing; response; treatment response

DESCRIPTION (provided by applicant): In the next phase of this longstanding project, we will conduct several cross-sectional and longitudinal studies focused on a dimensional approach to classification based on the shared features of internalizing disorders (IDs), large-scale clinical evaluation of several cognitive processing paradigms commonly used in cognitive and neuroscience studies of IDs, explication of genetic factors that influence temperament, cognitive processing biases, and the severity and course of ID psychopathology, and the refinement of the measurement of emotion dysregulation to examine the unique contribution of these constructs in predicting the severity and course of ID symptoms. 1,250 patients will be assessed with a broad suite of measures (e.g., clinical rating, self-report, laboratory tasks) of temperament, cognitive processing, vulnerability (e.g., emotion dysregulation), life stress, and ID symptoms, and will provide a blood or saliva sample for genetic analysis; 750 of these patients will be re-evaluated at 12- and 24-month follow-up (and 200 patients will be re-administered the cognitive processing tasks and study questionnaires following unified protocol treatment). These data will be used in studies that entail: (a) cross-sectional and longitudinal evaluation of a dimensional classification system based on the cross-cutting features of IDs; (b) evaluation of the differential predictive relationships of multiple aspects of cognitive processing (e.g., attention bias, emotion recognition, emotional memory) in cross-sectional and time-series structural models of temperament and ID psychopathology; (c) extensive measurement model evaluation of leading measures of emotional dysregulation and the relevance of emotional dysregulation to the phenomenology, severity, and temporal course of various ID symptom domains, (d) the strength and specificity of the effects of novel candidate genes derived from emerging GWAS on temperament, cognitive processing biases, and the severity and temporal course of ID psychopathology (and the potentiating effects of life stress and treatment), and (e) psychometrically oriented studies to address focal issues in measurement and classification. Key contributions of this work, which is focused on the cross-cutting dimensional features of IDs, include validation of a more robust organizational scheme that points us in the direction of etiology and prevention and predicts more precisely appropriate treatment selection, prognosis, and course. This work will also inform neurobiological studies by explicating a more valid and robust set of psychopathology and vulnerability constructs and mechanisms on which to base such investigations.

DESCRIPTION (provided by applicant): In the next phase of this longstanding project, we will conduct several cross-sectional and longitudinal studies focused on a dimensional approach to classification based on the shared features of internalizing disorders (IDs), large-scale clinical evaluation of several cognitive processing paradigms commonly used in cognitive and neuroscience studies of IDs, explication of genetic factors that influence temperament, cognitive processing biases, and the ID心理病理学的严重性和过程，以及对情绪失调的测量的完善，以检查这些结构在预测ID症状的严重性和过程中的独特贡献。 1,250名患者将通过一系列的气质，认知处理，脆弱性（例如情绪失调），生命压力和ID症状的措施（例如临床评级，自我报告，实验室任务）进行评估，并将为遗传分析提供血液或唾液样本；这些患者中有750例将在12个月和24个月的随访中重新评估（统一协议治疗后，将重新管理200名患者的认知处理任务，并研究问卷）。这些数据将用于需要的研究：（a）基于ID的横切特征对维度分类系统的横断面和纵向评估； （b）评估认知处理的多个方面的差异预测关系 （例如，注意力偏见，情绪识别，情绪记忆）在气质和ID心理病理学的横断面和时间序列结构模型中； （c）广泛的测量模型评估情绪失调的领先措施以及情绪失调与各种ID症状领域的现象学，严重程度和时间过程的相关性，（D）新型候选基因的强度和特异性来自于对气候，认知性的偏见和时间态度的偏见和时间态度的效果（启动性偏见）的强度和特异性（压力和治疗）以及（e）针对心理方向的研究，以解决测量和分类中的焦点问题。这项工作的关键贡献集中在ID的跨切割维度特征上，包括验证更强大的组织方案，该方案将我们指向病因和预防方向，并预测更准确地适当的治疗选择，预后和过程。这项工作还将通过阐明一组更有效，更健壮的心理病理学以及脆弱性结构和机制来为神经生物学研究提供依据。

项目成果

Stable "trait" variance of temperament as a predictor of the temporal course of depression and social phobia.

稳定的气质“特质”变异可以作为抑郁症和社交恐惧症时间过程的预测因子。

• DOI: 10.1037/a0032997
• 发表时间: 2013
• 期刊: Journal of abnormal psychology
• 影响因子: 4.6
• 作者: Naragon-Gainey,Kristin;Gallagher,MatthewW;Brown,TimothyA
• 通讯作者: Brown,TimothyA

The NEO Five-Factor Inventory: latent structure and relationships with dimensions of anxiety and depressive disorders in a large clinical sample.

• DOI: 10.1177/1073191110382848
• 发表时间: 2011-03
• 期刊: Assessment
• 影响因子: 3.8
• 作者: Rosellini AJ;Brown TA
• 通讯作者: Brown TA

A proposal for a dimensional classification system based on the shared features of the DSM-IV anxiety and mood disorders: implications for assessment and treatment.

• DOI: 10.1037/a0016608
• 发表时间: 2009-09
• 期刊: Psychological assessment
• 影响因子: 3.6
• 作者: Brown TA;Barlow DH
• 通讯作者: Barlow DH

The Multidimensional Emotional Disorder Inventory (MEDI): Assessing transdiagnostic dimensions to validate a profile approach to emotional disorder classification.

• DOI: 10.1037/pas0000649
• 发表时间: 2019-01
• 期刊: Psychological assessment
• 影响因子: 3.6
• 作者: Rosellini AJ;Brown TA
• 通讯作者: Brown TA

Generalized anxiety and generalized anxiety disorder: description and reconceptualization.

广泛性焦虑和广泛性焦虑症：描述和重新概念化。

• DOI: 10.1176/ajp.143.1.40
• 发表时间: 1986
• 期刊: The American journal of psychiatry
• 作者: Barlow,DH;Blanchard,EB;Vermilyea,JA;Vermilyea,BB;DiNardo,PA
• 通讯作者: DiNardo,PA