Epigenetic Predictors of Impairment in Very Preterm Infants

极早产儿损伤的表观遗传预测因子

基本信息

批准号：
9320798
负责人：
Barry M. Lester
金额：
$ 29.38万
依托单位：
WOMEN AND INFANTS HOSPITAL-RHODE ISLAND
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-08-01 至 2018-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9320798
关键词：
Address Adult Affect Age Behavior Biology Brain Injuries Candidate Disease Gene Cheek structure Chronic Disease Cost Analysis DNA Methylation DNA Sequence Data Data Analyses Development Environment Epigenetic Process Funding Gene Expression Genetic Gestational Age Goals Heritability Hypoxia Impaired cognition Impairment Infant Infant Mortality Inflammatory Intervention Lead Measures Medical Methods Mitotic Molecular Neonatal Neonatal Intensive Care Units Outcome Outcome Measure Parents Performance Premature Birth Premature Infant Public Health Risk Role Sampling Specimen Structure Swab Time Uncertainty Variant Visit Woman behavioral impairment brain cell caregiving cost epigenetic marker experience genome-wide high risk infant morbidity methylation pattern neurobehavior neurobehavioral parent grant postnatal public health relevance therapy development

项目摘要

DESCRIPTION (provided by applicant): We are currently conducting a study ("Neonatal Neurobehavior and Outcomes in Very Preterm Infants," 1R01HD072267-01A1) of infants born <30 weeks postmenstrual age (PMA). These infants experience potentially devastating brain injuries associated with immaturity, hypoxic insults, and inflammatory exposures and are at high risk for developing neuromotor, cognitive, and behavioral impairments that persist through adulthood. However, for the majority of infants, there is no reliable method during their stay in the Neonatal Intensive Care Unit (NICU) to distinguish infants who will go on to develop later impairments from those who will not. The goal of the "parent" grant is to determine which infants born <30 weeks PMA are at greatest risk for impaired development using a neurobehavioral assessment (the NICU Network Neurobehavioral Scale or NNNS) and a medical risk score. In this proposed study, we have added an objective that enhances and is within the scope of the "parent grant"; the study of epigenetic markers that regulate gene expression and could suggest molecular mechanisms involved in our study findings. We are collecting cheek swabs shortly before discharge from the NICU and at the 24-month outcome visit to be used for the epigenetic analysis. The epigenetic measures were not included in the parent grant because the cost to cover the analysis of these data was prohibitive. This application is a request for funds for the analysis of the epigenetic data already being collected in the parent grant. The addition of epigenetics is potentially of great importance and highly likely to increase the impact of the study.

描述（由申请人提供）：我们目前正在进行一项研究（“极早产儿的新生儿神经行为和结果”，1R01HD072267-01A1），研究对象是月经后 30 周以下出生的婴儿 (PMA)，这些婴儿可能会遭受与相关的潜在破坏性脑损伤。不成熟、缺氧和炎症暴露，并且处于发展神经运动、认知和行为的高风险然而，对于大多数婴儿来说，在新生儿重症监护病房 (NICU) 期间没有可靠的方法来区分将继续出现障碍的婴儿和不会出现障碍的婴儿。 “父母”补助金的目的是使用神经行为评估（NICU 网络神经行为量表或 NNNS）和医疗风险评分来确定哪些出生 <30 周 PMA 的婴儿发育受损的风险最大。研究中，我们增加了一个目标，该目标增强了对调节基因表达的表观遗传标记的研究，并在其范围内；我们正在出院前不久收集脸颊拭子。 NICU 和用于表观遗传分析的 24 个月结果访视时，表观遗传测量未包含在家长补助金中，因为分析这些数据的费用过高。已经分析了表观遗传数据表观遗传学的增加可能非常重要，并且很可能会增加该研究的影响。