Environmental Change and Inflammation: Age, Cohort and Household Effects in China

环境变化和炎症：中国的年龄、群体和家庭影响

• 批准号: 8637666
• 负责人: Amanda L Thompson
• 金额: $ 11.32万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-06-22 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8637666
• 关键词: Abdomen; Accounting; Acute-Phase Proteins; Address; Adolescence; Adolescent and Young Adult; Adult; Age; Anthropometry; Award; Behavioral; Biological; Biological Markers; Biological Models; C-reactive protein; Characteristics; Child; Childhood; China; Chronic; Chronic Disease; Cohort Analysis; Cohort Effect; Communities; Complex; Data; Data Set; Demography; Development; Diet; Disease; Environment; Environmental Exposure; Environmental Risk Factor; Epidemiologic Methods; Exposure to; Fatty acid glycerol esters; Fostering; Funding; Generations; Health; Health Surveys; Heterogeneity; Hormonal; Household; Human; Human Biology; Immunology; Individual; Inflammation; K-Series Research Career Programs; Laboratories; Life Cycle Stages; Life Style; Linear Models; Link; Longitudinal Studies; Measures; Mentors; Mentorship; Methods; Modeling; Modernization; Nutrition Surveys; Nutritional; Obesity; Outcome; Pathway interactions; Pattern; Physical activity; Physical environment; Population; Positioning Attribute; Prevalence; Recording of previous events; Research; Research Training; Rural; Sanitation; Scientist; Shapes; Social Environment; Socioeconomic Status; Testing; Training; United States; United States National Institutes of Health; Universities; Urbanization; Work; age group; age related; base; burden of illness; cohort; driving force; early life exposure; environmental change; experience; immune activation; improved; innovation; nutrition; pathogen exposure; public health relevance; residence; skills; social; successful intervention; tool; waist circumference; young adult

DESCRIPTION (provided by applicant): Early life exposure to changing social and physical environments has been implicated as a driving force in the increasing global prevalence of obesity and chronic disease at younger ages. However, understanding of the complex pathways linking environmental exposures to the development of health and disease across the life course has been limited by methodological difficulties in disentangling the effects of changing environments from individual, age-related vulnerability to environmental change. The proposed career development award addresses this gap, bringing together training in sophisticated demographic methods and a unique dataset, the China Health and Nutrition Study, a 20-year NIH study of >11,000 individuals in 4400 households capturing dramatic changes in diet, disease burden and lifestyles, to characterize environmental determinants of inflammation, a measure of chronic immune activation linked to the development of cardiometabolic disease. Drawing on a life course framework, this project examines the pathways linking social and physical environments to inflammation among children, adolescents and young adults through three specific aims: 1) the characterization of salient social, behavioral, biological and physical environmental predictors of inflammation across age groups and urban/rural residence, 2) the use of latent class trajectory models and age, period, cohort analysis to characterize longitudinal patterns of exposure to pathogenic and obesogenic environments, and 3) the identification of shared and unique predictors of inflammation within individual households to address age and cohort differences in vulnerability on the micro-environmental level. This award will incorporate formal training in demography, mentorship from leaders in the fields of demography and nutrition, and fieldwork in China to create innovative models more broadly applicable to questions of health in changing environments in China and globally. The institutional environments, the Carolina Population Center, UNC- Chapel Hill and Duke University, and mentoring by an inter-disciplinary team of experts, will foster the development of a new research niche linking a human biological focus on the development of chronic disease with sophisticated demographic analytic tools. This training and mentoring will provide the unique set of skills I need to make a large step forward from my background in narrower bench research and smaller-scale human biology work to become an independent population scientist with a dynamic perspective on the interplay of environment and inflammation and a capacity to make significant, interdisciplinary contributions to the study of human health and disease.

描述（由申请人提供）：生命早期接触不断变化的社会和物理环境被认为是全球年轻肥胖和慢性病患病率不断上升的驱动力。然而，对整个生命过程中环境暴露与健康和疾病发展之间联系的复杂途径的理解受到方法学上的困难的限制，难以将环境变化的影响与个人、与年龄相关的环境变化脆弱性分开。拟议的职业发展奖弥补了这一差距，将复杂的人口统计方法的培训和独特的数据集“中国健康与营养研究”结合起来，这是一项为期 20 年的 NIH 研究，对 4400 个家庭中的 11,000 多人进行了研究，捕捉了饮食、疾病负担和健康方面的巨大变化。生活方式，以表征炎症的环境决定因素，炎症是与心脏代谢疾病的发展相关的慢性免疫激活的衡量标准。该项目利用生命历程框架，通过三个具体目标，研究了将社会和物理环境与儿童、青少年和年轻人炎症联系起来的途径：1）突出的社会、行为、生物和物理特征 跨年龄组和城市/农村居住的炎症的环境预测因子，2）使用潜在类别轨迹模型和年龄、时期、队列分析来表征纵向特征 暴露于致病和致肥胖环境的模式，以及3）识别各个家庭内共同和独特的炎症预测因子，以解决微环境水平上脆弱性的年龄和群体差异。该奖项将包括人口学方面的正式培训、人口学和营养领域领导者的指导以及在中国的实地考察，以创建更广泛地适用于中国和全球不断变化的环境中的健康问题的创新模型。卡罗莱纳州人口中心、北卡罗来纳大学教堂山分校和杜克大学的机构环境，以及跨学科专家团队的指导，将促进新研究领域的发展，将人类生物学对慢性病发展的关注与复杂的疾病联系起来。人口统计分析工具。这种培训和指导将提供我所需的独特技能，使我从较窄的实验室研究和较小规模的人类生物学工作的背景迈出一大步，成为一名独立的人口科学家，对环境和炎症的相互作用有动态的视角以及为人类健康和疾病研究做出重大跨学科贡献的能力。