Development of fMRI Studies of Social-Emotional Information Processing

社会情感信息处理的功能磁共振成像研究进展

基本信息

批准号：
8702238
负责人：
EMIL Frank COCCARO
金额：
$ 19.75万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-07-16 至 2015-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8702238
关键词：
Affect Affective Aggressive behavior Amygdaloid structure Anger Anterior Area Behavior Benign Biological Neural Networks Brain Brain region Clip Cognition Cognitive Development Emotional Emotions Functional Magnetic Resonance Imaging Funding Mechanisms Hostility Individual Insula of Reil Intermittent Explosive Disorders Lateral Lead Measures Neurons Paper Parahippocampal Gyrus Personality Disorders Phase Prefrontal Cortex Process Property Protocols documentation Psychometrics Published Comment Reaction Recording of previous events Recurrence Regulation Series Signal Transduction Social Interaction Societies Staging Stimulus Study Subject Testing Work Writing base cingulate cortex healthy volunteer information processing insight neuropsychological public health relevance relating to nervous system response social visual stimulus

项目摘要

DESCRIPTION (provided by applicant): In this R21 application, we propose to build on work with recently developed Social-Emotional Information processing (SEIP) visual stimuli. These stimuli are composed of short video clips based on written SEIP vignettes that have already been shown to have excellent psychometric properties. We propose to develop and refine an fMRI protocol to examine neural networks related to the various aspects of SEIP. These relate to viewing (encoding), hostile attribution, and negative emotional response. The first group of subjects will include healthy volunteer subjects. The second group of subjects will include individuals with prominent histories of recurrent, problematic, impulsive aggression (Intermittent Explosive Disorder: IED). The fMRI-SEIP protocol will define the neural networks involved in the different aspects of SEIP in healthy volunteers. Then the fMRI protocol will be studied in subjects with histories of recurrent, problematic, impulsive aggression (IED). We hypothesize that: a) during the "Viewing Phase", increased fMRI BOLD signal response will be observed in brain regions associated with cognitive appraisal (DLPFC, OFC, PHG) and affective reaction (AMYG, ACC, INS), b) during the "Attribution Phase", increased fMRI BOLD signal response will be observed in brain regions associated with cognitive appraisal (DLPFC, OFC, PHG, PCN), c) during the "Negative Emotional Response Phase", increased fMRI BOLD signal response will be observed in brain regions associated with affective reaction (AMYG, ACC, INS) and that, d) scores of "Hostile Attribution" and of "Negative Emotional Response" (which both connote the extent of provoked anger/hostility/negative affect) scores will correlate with activation of AMYG, ACC, OFC, and INS. Finally, we hypothesize that, compared with Healthy Control subjects, impulsive aggressive subjects (IED) will demonstrate reduced brain activation during the Attribution (cognitive appraisal) in DLPFC, OFC, PHG, and PCN and heightened brain activation during the "Negative Emotional Response" (affective reaction) in AMYG, ACC, INS.

描述（由申请人提供）：在此 R21 申请中，我们建议以最近开发的社交情感信息处理（SEIP）视觉刺激为基础。这些刺激由基于书面 SEIP 插图的短视频片段组成，这些片段已被证明具有出色的心理测量特性。我们建议开发和完善功能磁共振成像协议来检查与 SEIP 各个方面相关的神经网络。这些与观看（编码）、敌意归因和负面情绪反应有关。第一组受试者将包括健康志愿者受试者。第二组受试者将包括具有反复、有问题、冲动攻击（间歇性爆炸性障碍：IED）的显着历史的个体。 fMRI-SEIP 协议将定义健康志愿者中涉及 SEIP 不同方面的神经网络。然后，功能磁共振成像方案将在有反复、有问题、冲动攻击（IED）历史的受试者中进行研究。我们假设：a) 在“观看阶段”，在与认知评估（DLPFC、OFC、PHG）和情感反应（AMYG、ACC、INS）相关的大脑区域将观察到 fMRI BOLD 信号反应增加，b）在“观看阶段” “归因阶段”，在“消极情绪反应”期间，与认知评估相关的大脑区域（DLPFC、OFC、PHG、PCN）将观察到 fMRI BOLD 信号反应增加，c) “阶段”，在与情感反应相关的大脑区域（AMYG、ACC、INS）将观察到 fMRI BOLD 信号反应增加，并且，d）“敌意归因”和“消极情绪反应”的分数（两者都表示激怒/敌意/负面情绪）分数将与 AMYG、ACC、OFC 和 INS 的激活相关。最后，我们假设，与健康对照受试者相比，冲动攻击受试者（IED）在 DLPFC、OFC、PHG 和 PCN 归因（认知评估）期间表现出大脑激活减少，而在“消极情绪反应”期间大脑激活增强AMYG、ACC、INS 中的（情感反应）。