District of Columbia Intellectual and Developmental Disabilities Research Center

哥伦比亚特区智力与发育障碍研究中心

基本信息

批准号：
9355675
负责人：
Vittorio Gallo
金额：
$ 116.36万
依托单位：
CHILDREN'S RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-22 至 2021-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9355675
关键词：
Academic Medical Centers Address Affect Animal Testing Animals Area Attenuated Behavioral Biological Markers Brain Brain Injuries Brain imaging Caring Cells Cerebellum Child Clinical Clinical Research Cognitive Collaborations Communication Communities Companions Core Facility DNA analysis Development Developmental Disabilities Disease District of Columbia Doctor of Philosophy Education Educational Curriculum Educational workshop Enhancement Technology Ensure Environment Evaluation Evolution Family Funding Future Gap Junctions Genomics Goals Grant Growth Health system Hereditary Disease Home environment Human Image Analysis Imaging Device Imaging technology Individual Injury Innovative Therapy Institution Intellectual functioning disability Interdisciplinary Study International Intervention Investigation Laboratories Lead Link Mental Retardation and Developmental Disabilities Research Centers Messenger RNA Microscopy Mission Molecular National Institute of Child Health and Human Development Neurobehavioral Manifestations Neuropsychology Neurosciences Outcome Measure Pathology Phenotype Pilot Projects Play Postdoctoral Fellow Premature Infant Prevention approach Prevention strategy Proteomics Rare Diseases Recruitment Activity Research Research Personnel Research Project Grants Research Support Resources Role Science Scientist Statistical Data Interpretation Strategic Planning Structure Sum Technology Therapeutic Tissues Training Training and Education Translating Translational Research Universities Washington animal imaging bench to bedside cellular imaging clinical development cognitive development cohesion collaborative environment community center cost effective design effective therapy fetal fundamental research health disparity human imaging image processing improved in vivo innovation molecular imaging multidisciplinary neurobehavioral neuroimaging next generation sequencing novel diagnostics novel therapeutics pre-clinical premature prevent programs quality assurance response success synergism tool training opportunity treatment strategy

项目摘要

Funded since 2001, the mission of the DC-IDDRC is to expand our understanding of the causes underlying intellectual and developmental disabilities (IDD), develop innovative therapies, and prevent or attenuate the full effects of these disorders, so that each child can achieve her/his full physical and intellectual potential. To realize this mission, we provide a rich environment for performing fully translational IDDR in the four collaborating DC academic medical centers (Children’s National Health System (lead), George Washington University, Howard University, and Georgetown University). In this proposal, our specific aims are: 1) To identify the causes and develop new clinical approaches for the prevention or amelioration of IDD; 2) To provide accessible, state-of-the-art and cost-effective core facilities for cohesive, multidisciplinary research and education/training in IDDR; 3) To create an intellectual home for investigators engaged in IDDR; and 4) To implement an innovative Research Project that addresses one of the five IDDR themes (Developing Biomarkers of Premature Brain Injury). The Director of the DC-IDDRC, Vittorio Gallo, PhD, is an internationally renowned neuroscientist who will continue to direct the Administrative Core that functions as the organizing nexus of the DC-IDDRC, providing management, administration, communication and training, assuring compliance and quality assurance, directing strategic planning and recruitment, and promoting the growth of the DC-IDDRC. The scientific cores provide an integrated platform and synergy for investigation as required by truly translational IDDR. The Clinical Translational Core (CTC) is designed to serve as a “one-stop-shop” for IDDR investigators, providing assistance at each stage of the clinical and translational research spectrum and optimizing the efficient, high quality implementation of fundamental research. The Genomics and Proteomics Core (GPC) provides advanced genomics and proteomics technologies, as well as specialized statistical analyses for DNA, mRNA and proteomics studies. The Cell and Tissue Microscopy Core (CTMC) supports investigators with a broad array of advanced cellular and molecular imaging tools for state-of-the-art neuroscience studies. The Human and Animal Imaging Core (HAIC) provides scientific and technical support for in vivo and ex vivo whole brain imaging, image processing, and image analysis for both human and animal studies. The Neurobehavioral Evaluation Core (NEC) provides sophisticated neurobehavioral and neuropsychological research support to define developmental and behavioral phenotypes in humans and animals. Our hypothesis-driven project is entitled “The vulnerable preterm cerebellum: Elucidating mechanisms and consequences of injury”. It utilizes the HAIC, NEC and CTC functions. Through these components, the DC-IDDRC will enhance the recruitment of investigators, generate innovation, and promote transdisciplinary research that together will facilitate the development, implementation, and dissemination of new diagnostic and therapeutic advances for the care of individuals with IDD.!

DC-IDDRC的任务从2001年起资助，是扩展我们对基本原因的理解智力和发育障碍（IDD），开发创新的疗法，并预防或衰减这些疾病的影响，以便每个孩子都能实现她/他的全部身体和智力潜力。到意识到这一任务，我们为在四个合作DC学术医疗中心（儿童国家卫生系统（LEAD），乔治·华盛顿大学，霍华德大学和乔治敦大学）。在此提案中，我们的具体目标是：1）确定原因并开发出预防或改善IDD的新临床方法； 2）到提供可访问的，最先进的和具有成本效益的核心设施，用于凝聚力，多学科研究和 IDDR的教育/培训； 3）为从事IDDR的调查人员创建知识分子；和4）到实施一个创新的研究项目，该项目涉及五个IDDR主题之一（开发）过早脑损伤的生物标志物）。 DC-IDDRC的主任Vittorio Gallo博士是国际著名的神经科学家，他将继续指导其作为组织的行政核心 DC-IDDRC的联系，提供管理，管理，沟通和培训，确保合规性和质量保证，指导战略规划和招聘，并促进 DC-IDDRC。科学核心提供了一个集成的平台和协同作用，以进行投资真正翻译的IDDR。临床翻译核心（CTC）旨在用作“一站式” IDDR调查人员，在临床和翻译研究范围的每个阶段提供帮助，优化基本研究的高效，高质量实施。基因组学和蛋白质组学 Core（GPC）提供高级基因组学和蛋白质组学技术以及专业统计数据 DNA，mRNA和蛋白质组学研究的分析。细胞和组织显微镜核心（CTMC）支持具有广泛的先进细胞和分子成像工具的研究人员用于最先进神经科学研究。人类和动物成像核心（HAIC）提供科学和技术支持用于体内和体内整个大脑成像，图像处理和人类和动物的图像分析研究。神经行为评估核心（NEC）提供了精致的神经行为和神经心理学研究支持，以定义人类的发展和行为表型动物。我们的假设驱动的项目标题为“脆弱的早产小脑：阐明机制和伤害的后果”。它利用了HAIC，NEC和CTC功能。 DC-IDDRC将增强调查人员的招聘，产生创新并促进跨学科研究将共同支持新诊断的开发，实施和传播 IDD个人护理的治疗进展。