Aspen Lung Conference: Environment and Global Lung Health, Susceptibility, and Intervention

阿斯彭肺部会议：环境和全球肺部健康、易感性和干预

• 批准号: 9327639
• 负责人: LISA A MAIER
• 金额: $ 3万
• 依托单位: NATIONAL JEWISH HEALTH
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9327639
• 关键词: Address; Air Pollutants; Asthma; Biology; Chronic Disease; Chronic Obstructive Airway Disease; Chronic lung disease; Clinical; Development; Diffuse; Disease; Environment; Environmental Exposure; Epigenetic Process; Exposure to; Fibrosis; Functional disorder; Generations; Genetic; Genomics; Goals; Health; International; Intervention; Knowledge; Lead; Lung; Lung diseases; Malignant Neoplasms; Molecular; Molecular Biology; Obstructive Lung Diseases; Occupational; Patients; Performance; Populations at Risk; Predisposition; Prevalence; Public Health; Pulmonary Fibrosis; Research; Research Personnel; Scientific Advances and Accomplishments; Series; Translating; Translations; burden of illness; environmental tobacco smoke exposure; global health; improved; interest; novel strategies; pre-clinical; prevent; programs; public health relevance; success; symposium; toxicant; Address; Air Pollutants; Asthma; Biology; Chronic Disease; Chronic Obstructive Airway Disease; Chronic lung disease; Clinical; Development; Diffuse; Disease; Environment; Environmental Exposure; Epigenetic Process; Exposure to; Fibrosis; Functional disorder; Generations; Genetic; Genomics; Goals; Health; International; Intervention; Knowledge; Lead; Lung; Lung diseases; Malignant Neoplasms; Molecular; Molecular Biology; Obstructive Lung Diseases; Occupational; Patients; Performance; Populations at Risk; Predisposition; Prevalence; Public Health; Pulmonary Fibrosis; Research; Research Personnel; Scientific Advances and Accomplishments; Series; Translating; Translations; burden of illness; environmental tobacco smoke exposure; global health; improved; interest; novel strategies; pre-clinical; prevent; programs; public health relevance; success; symposium; toxicant

PROJECT SUMMARY/ABSTRACT With an emphasis on the integration of basic, translational and clinical approaches, the 60th annual Thomas L. Petty Aspen Lung Conference will focus on a central question: how can knowledge of the mechanisms underlying exposure-induced chronic lung diseases be translated into effective approaches to treat and ultimately prevent the burden of these lung diseases? To address this central question, we have organized the program into a series of thematic sessions focusing on (i) the magnitude and burden of exposure-induced lung diseases as well as the impact these chronic diseases are having on global health (ii) exposure assessment , exposure biology and the susceptible host, (iii) the molecular mechanisms of exposure that result in fibrosis, asthma and other chronic lung diseases, (iv) epigenetic, genetic, and genomic interactions with the environment, resulting in obstructive lung disease, cancer, and pulmonary fibrosis and (v) strategic approaches to translate scientific advances to prevent and intervene to reduce exposures and improve lung health. By addressing these topics across five thematic sessions, we seek to accomplish the following objectives: 1) To provide an international forum for leading basic, translational, and clinical researchers to exchange ideas regarding fundamental concepts regarding the contribution of exposure and susceptibility to development of chronic lung disease. 2) To stimulate interactions between the scientific fields of exposure biology, molecular biology, epigenetics, genetics, genomics and public health with the goal of identifying emerging, shared interests that may lead to the performance of more efficient and productive research. 3) To enhance the likelihood of success in translation of preclinical scientific advances into direct patient benefit by developing novel strategies to better implement scientific advances in treatment and reduction in exposures to enhance lung health globally. 4) To challenge and stimulate the scientific interests of trainees, attracting a new generation of junior investigators into the field of exposure-induced lung disease and global health.

项目摘要/摘要 第60届年度Thomas L.着重于基本，转化和临床方法的整合。 小阿斯彭肺会议将重点关注一个中心问题：如何了解机制 潜在的暴露诱发的慢性肺部疾病被转化为有效治疗和治疗的方法 最终防止这些肺部疾病的负担？为了解决这个中心问题，我们已经组织了 该计划分为一系列主题会议，重点是（i）曝光引起的大小和负担 肺部疾病以及这些慢性疾病对全球健康的影响（II）暴露评估 ，暴露生物学和易感宿主，（iii）导致纤维化的暴露的分子机制， 哮喘和其他慢性肺疾病，（iv）表观遗传，遗传和基因组相互作用与环境相互作用， 导致阻塞性肺部疾病，癌症和肺纤维化以及（v）翻译的战略方法 预防和干预以减少暴露并改善肺部健康的科学进步。通过解决这些问题 在五个主题会议上的主题，我们试图实现以下目标： 1）提供一个国际论坛，用于领导基本，转化和临床研究人员交流 关于有关暴露和易感性贡献的基本概念的想法 慢性肺部疾病的发展。 2）刺激暴露生物学，分子生物学，表观遗传学的科学领域之间的相互作用 遗传学，基因组学和公共卫生的目的是确定可能 导致更高效和生产性研究的表现。 3）增强了将临床前科学进步转化为直接患者的成功的可能性 通过制定新的策略来更好地实施治疗和减少的科学进步来受益 在全球增强肺部健康的暴露中。 4）挑战和刺激学员的科学利益，吸引了新一代的初级 研究人员研究了暴露诱发的肺部疾病和全球健康。