Effects of Dietary Blackcurrant Extract and PCSO-524

膳食黑加仑提取物和 PCSO-524 的作用

• 批准号: 9553315
• 负责人: Marguerite Engler
• 金额: $ 22.71万
• 依托单位: NATIONAL INSTITUTE OF NURSING RESEARCH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9553315
• 关键词: Age; Ankle; Antioxidants; Arteries; Atherosclerosis; Biological Availability; Biological Markers; Blood Vessels; Diet; Elderly; Fatty Acids; Flavonoids; Health; Inflammation; Injury; Lip structure; Lipids; Mediating; Mussels; Nitric Oxide; Oils; Omega-3 Fatty Acids; Oxidative Stress; Phase; Placebos; Property; Randomized; Source; Structure; Supplementation; Vasodilator Agents; Visit; arterial stiffness; brachial artery; cardiovascular disorder risk; cardiovascular risk factor; disorder risk; double-blind placebo controlled trial; endothelial dysfunction; fruits and vegetables; improved; indexing; interest

Numerous studies have shown the beneficial effects of fruits, vegetables and omega-3 fatty acids in reducing the risk of cardiovascular disease. The cardioprotective properties may be attributed to the bioactive compounds found in fruits and vegetables called flavonoids. High concentrations of flavonoids with antioxidant activity are found in blackcurrant extract. Flavonoids like omega-3 fatty acids may improve vascular function by increasing the bioavailability of nitric oxide, a potent vasodilator. PCSO-524 (Pernacanaliculus supercritical oil) is of particular interest as a rich source of omega-3 fatty acids derived from the green-lipped mussel. The objectives of this study are to determine the effects of blackcurrant extract, PCSO-524 or the combination of blackcurrant extract & PCSO-524 on endothelial function (flow-mediated brachial artery dilation) and arterial stiffness (cardio-ankle vascular index) as indicators of cardiovascular risk and atherosclerosis. These indices also provide an assessment of structure and function of the artery. The effects of the supplements on biomarkers of vascular health (endothelial dysfunction, inflammation, injury, oxidative stress, nitric oxide status), lipids and fatty acid profile, and flavonoid profiles will also be determined. In a randomized, double-blind, placebo-controlled trial, one hundred twenty-two healthy older adults (ages 55-75) will be given either blackcurrant extract (1000 mg), PCSO-524 (400 mg), or blackcurrant extract (1000 mg) & PCSO-524 (400 mg) daily for 8 weeks while consuming their usual diet. The study will include 4 visits at 8 week intervals consisting of treatment, washout and placebo phases.

大量研究表明，水果，蔬菜和omega-3脂肪酸对降低心血管疾病的风险有益。 心脏保护特性可能归因于称为类黄酮的水果和蔬菜中发现的生物活性化合物。 在黑加仑提取物中发现了具有抗氧化活性的高浓度的类黄酮。 像omega-3脂肪酸这样的类黄酮可以通过增加一氧化氮的生物利用度（一种有效的血管扩张剂）的生物利用度来改善血管功能。 PCSO-524（Pernacanaliculus超临界油）特别是源自绿色贻贝的欧米茄3脂肪酸的丰富来源。 这项研究的目的是确定黑加仑提取物，PCSO-524或黑加仑提取物和PCSO-524的组合对内皮功能（流介导的臂动脉膨胀）和动脉僵硬（心脏 - 伴随血管指标）作为心血管风险和胸腔内科症的指标。 这些指数还提供了动脉结构和功能的评估。补充剂对血管健康生物标志物的影响（内皮功能障碍，炎症，损伤，氧化应激，一氧化氮状况），脂质和脂肪酸概况以及类黄酮谱也将得到确定。在一项随机的，双盲的，安慰剂对照试验中，将给予一百二十二名健康的老年人（55-75岁），要么是黑克罗植物提取物（1000 mg），PCSO-524（400毫克），或黑加仑剂（400毫克），或每天消耗8周的日分饮食，每天消耗8周的日常用户，而黑加仑（400 mg）或黑加度提取物（1000 mg）和PCSO-524（400 mg）。该研究将包括4周的间隔4次访问，包括治疗，清洗和安慰剂相。

项目成果

Enteral nutritional intake in adult korean intensive care patients.

韩国成年重症监护患者的肠内营养摄入。

• DOI: 10.4037/ajcc2013629
• 发表时间: 2013
• 期刊: American journal of critical care : an official publication, American Association of Critical-Care Nurses
• 作者: Kim,Hyunjung;Stotts,NancyA;Froelicher,ErikaS;Engler,MargueriteM;Porter,Carol
• 通讯作者: Porter,Carol

Adequacy of early enteral nutrition in adult patients in the intensive care unit.

重症监护病房成年患者早期肠内营养的充分性。

• DOI: 10.1111/j.1365-2702.2012.04218.x
• 发表时间: 2012
• 期刊: Journal of clinical nursing
• 影响因子: 4.2
• 作者: Kim,Hyunjung;Stotts,NancyA;Froelicher,ErikaS;Engler,MargueriteM;Porter,Carol;Kwak,Heejeong
• 通讯作者: Kwak,Heejeong

Knowledge and beliefs about smoking and goals for smoking cessation in hospitalized men with cardiovascular disease.

• DOI: 10.1016/j.hrtlng.2012.11.010
• 发表时间: 2013-03
• 期刊: Heart & lung : the journal of critical care
• 作者: Elshatarat RA;Stotts NA;Engler M;Froelicher ES
• 通讯作者: Froelicher ES