Neural markers of speech error detection and correction abilities in aphasia

失语症言语错误检测和纠正能力的神经标志物

• 批准号: 9561389
• 负责人: Caroline Niziolek
• 金额: $ 24.9万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9561389
• 关键词: Acoustics; Agreement; Anatomy; Aphasia; Area; Auditory; Auditory system; Award; Beds; Behavioral; Biological Assay; Biological Markers; Boston; Brain region; Classification; Clinical; Cognitive deficits; Communication; Communication impairment; Data; Detection; Development Plans; Diagnosis; Diagnostic tests; Disease; Etiology; Failure; Feedback; Goals; Impairment; Individual; Language; Learning; Lesion; Location; Magnetic Resonance Imaging; Magnetoencephalography; Maps; Measures; Mentors; Monitor; Motor; Motor output; Participant; Pathologic; Pathway interactions; Patients; Pattern; Perception; Phase; Plant Roots; Population; Production; Research; Resolution; Series; Signal Transduction; Source; Speech; Speech Disorders; Speech Perception; Speech Sound; Speech Therapy; Stroke; Symptoms; System; Techniques; Testing; Time; Training; Unconscious State; Universities; Variant; Vision; Visual; Voice; Work; aphasic; base; career development; deviant; improved; individual patient; individualized medicine; learning ability; motor control; motor learning; neuroimaging; neurophysiology; novel; personalized medicine; public health relevance; relating to nervous system; research clinical testing; response; sensory feedback; sensory input; stem; temporal measurement; theories; translational research program; visual feedback; visual processing

 DESCRIPTION (provided by applicant): Individuals with aphasia, a disorder caused by damage to language-related brain regions, are often afflicted with speech production difficulties that greatly impair communication. The goal of this K99/R00 Pathway to Independence Award is to provide the candidate, Dr. Caroline Niziolek, with a strong grounding in patient- based research and cutting-edge neural connectivity analysis, enabling her to apply her expertise in speech motor control to investigate the functional abnormalities at the root of this communication disorder. In this proposal, Dr. Niziolek aims to identify the neurophysiological causes of speech production deficits in aphasia and to assess whether feedback-based speech training can ameliorate them. Her recent neuroimaging research in healthy speakers suggests that the auditory system constantly monitors its own speech for small deviations from intended speech sounds, and that successful monitoring may drive an unconscious motor correction of these deviations before they are realized as errors. The central hypothesis of this project is that in speakers with aphasia, production deficits may be due to a failure of detection: that is, the auditory system is not sensitive to an aphasic speaker's own deviations until after they become full-blown speech errors. Importantly, in testing this hypothesis, Dr. Niziolek will look across aphasic patients, regardless of their lesion location or clinically-defined subtype, using an objective neural marker she developed to assess detection ability. Her immediate goal for the K99 phase is to use this neural marker, along with behavioral metrics, to characterize each individual's deficit as either perceptual (difficulty detecting one's own errors) or motor (preservd ability to detect errors but difficulty in carrying out corrective commands). She will then relate these objectively-measured deficits to patterns of lesions and magnetoencephalographic (MEG) connectivity to determine the structural and functional network abnormalities that cause each type of deficit. With this understanding, she plans to carry out a novel speech production training study in the R00 phase of the award. The proposed speech training game uses a visual cursor that is mapped to acoustic input so that participants can use their voice to move the cursor to a visual target. The target will correspond to the production of a given speech sound, such as the "e" in "bed." This training provides a secondary source of sensory feedback for the detection of deviations from a target. By training aphasic patients to learn to hit vocal targets using visual feedback, Dr. Niziolek aims to use an intact system (vision) to retrain the damaged one (auditory detection). Her long-term goal is to use this paradigm in conjunction with the neural marker assessment to develop personalized treatments that are tailored to each patient's specific functional deficit (auditory detection or motor correction). This research career development plan will be carried out at Boston University with an impressive co-mentor team from whom she will gain invaluable clinical and technical training, with the ultimate aim of developing a translational research program that can be extended to other speech disorders.

 描述（由适用提供）：失语症的个体是对与语言相关的大脑区域损害造成的疾病，通常会遭受言语生产困难，极大地损害了沟通。这项K99/R00独立奖的目标是为候选人Caroline Niziolek博士提供基于患者的研究和尖端神经连通性分析的牢固基础，使她能够在这种通信障碍的根部应用语音运动的专业知识来研究功能异常。在此提案中，尼兹奥莱克博士旨在确定失语症中语音生产定义的神经生理原因，并评估基于反馈的语音培训是否可以改善它们。她最近在健康演讲者中进行的神经影像学研究表明，听觉系统不断监视自己的演讲，以偏离预期的语音，并且成功的监控可能会在这些偏离的情况下纠正这些偏离，然后才能意识到这些偏离。该项目的中心假设是 在失语症的演讲者中，生产定义可能是由于检测失败而引起的：也就是说，听觉系统直到他们成为成熟的语音错误之前，对失语扬声器的出发行为不敏感。重要的是，在检验这一假设时，尼齐洛克博士将使用她开发的客观神经标记物来评估检测能力。她的K99阶段的直接目标是使用此神经元标记以及行为指标，将每个人的防御表征为感知（难以检测自己的错误）或电动机（保留了检测错误但难以执行纠正命令的能力）。然后，她将将这些客观测量的缺陷与病变和磁脑电图（MEG）连接的模式联系起来，以确定导致每种防御类型的结构和功能网络异常。有了这种理解，她计划进行新的语音制作培训 在奖项的R00阶段进行研究。提出的语音训练游戏使用视觉光标，该光标被映射到声学输入，以便参与者可以使用声音将光标转移到视觉目标。目标将对应于给定语音的产生，例如“床”中的“ e”。该培训为检测到目标的出发提供了感官反馈的次要来源。通过训练失败者的患者学习使用视觉反馈来达到人声目标，Niziolek博士旨在使用完整的系统（视觉）来重新训练受损的人（审核员检测）。她的长期目标是将此范式与神经标志物评估结合使用，以开发针对每个患者的特定功能不足（审核员检测或运动校正）量身定制的个性化治疗方法。这项研究职业发展计划将在波士顿大学与一支令人印象深刻的同事团队一起制定，她将获得宝贵的临床和技术培训，最终的目的是制定可以扩展到其他语音障碍的翻译研究计划。