Thermoacoustic Range Verification During Delivery of a Clinical Plan by a Synchrocyclotron: transition from research prototype to turnkey clinical device

同步回旋加速器交付临床计划期间的热声范围验证：从研究原型到交钥匙临床设备的过渡

• 批准号: 10600975
• 负责人: SARAH Kathryn PATCH
• 金额: $ 37.8万
• 依托单位: ACOUSTIC RANGE ESTIMATES, LLC
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10600975
• 关键词: 3D Print; Acoustics; Address; Agreement; American; Anatomy; Body Weight decreased; Caring; Certification; Charge; Chronic; Clinic; Clinical; Closure by clamp; Collaborations; Computer Systems; Computer software; Cost efficiency; Custom; Data; Defecation; Deposition; Devices; Digestion; Distal; Dose; Edema; Electronics; Environment; Equipment Failure; Eye; Frequencies; Funding; Gases; Gelatin; Goals; Hybrids; Hydrogels; Image; Imaging Phantoms; Intestines; Ions; Kidney; Legal patent; Liver; Magnetic Resonance Imaging; Manufacturer; Medicare; Modeling; Monitor; Monte Carlo Method; Morphology; Motion; Multimodal Imaging; Neck; Noise; Organ; Pancreas; Patient imaging; Patients; Performance; Phase; Photons; Positioning Attribute; Protocols documentation; Radiation Oncology; Radiation therapy; Research; Respiration; Rest; Roentgen Rays; Sampling; Secure; Selection for Treatments; Signal Transduction; Site; Societies; Solid Neoplasm; Speed; Spottings; Stress; Structure; Synchrocyclotron; System; Techniques; Testing; Therapeutic; Time; Tissues; Treatment Cost; Ultrasonography; Uncertainty; Universities; Validation; Vertebral column; Visualization; Washington; X-Ray Medical Imaging; analog; base; bundled payment; clinical efficacy; cone-beam computed tomography; cost effectiveness; data acquisition; design; detector; dosimetry; experimental study; improved; innovation; millimeter; particle; particle therapy; pediatric patients; proton beam; proton therapy; prototype; radiation detector; research study; soft tissue; software systems; success; treatment planning; tumor; ultrasound; wireless

Particle therapy is a technique for treating solid tumors that is potentially more precise than x-ray radiation therapy. Charged particles enter the patient at relativistic speeds, depositing increasingly more dose as they come to rest inside the patient. X-ray photon beams deliver an exponentially decaying dose along the beam path, dosing healthy tissue before and after the tumor. Proton therapy causes less collateral damage, and when patient alignment is accurate, delivers less dose to healthy proximal tissue and spares distal tissue altogether. Today, patients are positioned by matching bony structures in daily x- ray images to planning CT volumes acquired days (or weeks) prior. Inter-fraction changes to soft tissue (weight loss, edema) are common and intra-fraction changes (digestion, respiration, etc.) are unavoidable. Range errors incorrectly dose healthy tissue and undertreat the tumor, limiting benefits of proton therapy. Therefore, the American Society for Therapeutic Radiation Oncology currently supports proton therapy for tumors near the base of the neck, spine, eye and in pediatric patients, and only in the context of research studies for most other tumor sites. Thermoacoustic range verification relies upon stress confinement and is suitable for compact synchrocyclotrons recently introduced by two manufacturers, IBA and Mevion. A prototype system has been validated for use with IBA systems and the same receive chain has been validated for Mevion. System design for a thermoacoustic range verification (tARV) device will be finalized and validated during Phase II. The tARV consists of a wireless ultrasound array around which six thermoacoustic receivers are packed. A compact (65mm x 55mm) data acquisition (DAQ) board provides 56-59 dB gain over the thermoacoustic frequency range of 10-100 kHz, samples at 500 ksps to minimize aliasing of high frequency noise, and stores data to a secure data card onboard. A compact gamma detector monitors beam intensity and provides a trigger to the DAQ. End-to-end validation requires software integration with the treatment planning system (TPS) software used in radiotherapy clinics. Furthermore, QA and clinically realistic test objects, called phantoms, are required. Thermoacoustics is a hybrid technique that combines aspects of ultrasound imaging and radiation therapy. Commercial phantoms designed for ultrasound imaging have not yet been vetted for radiation therapy. We will integrate software, quantify materials in ultrasound phantoms already produced by CIRS, Inc and add dosimetric capability to enable end-to-end validation in a clinical environment.

粒子治疗是一种治疗实体瘤的技术，它可能比X射线放射治疗更精确。 带电的颗粒以相对论的速度进入患者，当他们放置在内部时越来越多的剂量 病人。 X射线光子梁沿梁路径呈指数衰减的剂量，在之前和 肿瘤后。 质子治疗会造成较少的附带损害，并且当患者对准准确时，对健康的剂量较少 近端组织和备距远端组织。如今，通过将每日x-中的骨结构匹配来定位。 射线图像在计划获得的CT卷之前（或几周）。分裂间变化对软组织（体重减轻，水肿） 是常见的，分数的变化（消化，呼吸等）是不可避免的。范围错误不正确地剂量健康 肿瘤的组织和未修复，限制了质子治疗的益处。因此，美国治疗学会 辐射肿瘤学目前支持颈部，脊柱，眼睛和小儿底部附近肿瘤的质子治疗 患者，仅在大多数其他肿瘤部位的研究中。 热声范围验证依赖于应力限制，适合紧凑的同步性囊肿 最近由两家制造商IBA和Mevion介绍。原型系统已经过验证以与IBA一起使用 系统和相同的接收链已被验证为Mevion。 热声范围验证（TARV）设备的系统设计将在阶段完成和验证 ii。 TARV由一个无线超声阵列组成，周围有六个热声接收器。紧凑 （65mm x 55mm）数据采集（DAQ）板在10-100的热声频率范围内提供56-59 dB的增益 KHz，在500 ksps处采样，以最大程度地减少高频噪声的混叠，并将数据存储到船上的安全数据卡中。一个 紧凑型伽马检测器监测光束强度，并为DAQ提供触发器。 端到端验证需要与处理计划系统（TPS）软件集成的软件 放疗诊所。此外，需要质量检查和临床现实的测试对象，称为幻影。热声学 是一种结合超声成像和放射疗法方面的混合技术。商业幻影设计 对于超声成像，尚未审查放射治疗。我们将整合软件，量化材料 CIRS，Inc和添加剂量学能力已经产生的超声幻象 临床环境。