Head Up Cardiopulmonary Resuscitation Device

平视心肺复苏装置

基本信息

批准号：
9408319
负责人：
Keith Lurie
金额：
$ 22.49万
依托单位：
MINNESOTA RESUSCITATION SOLUTIONS, LLC
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-17 至 2019-07-16
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9408319
关键词：
Abdomen Accident and Emergency department American Americas Animal Model Animals Award Blinded Blood Blood Circulation Blood Gas Analysis Blood flow Brain Brain Injuries Cadaver Carbon Dioxide Cardiac Cardiac Catheterization Procedures Cardiopulmonary Resuscitation Caring Cause of Death Cerebral perfusion pressure Cerebrovascular Circulation Cerebrum Chest Clinical Clinical Trials Communities Coronary Device Designs Devices Disease Drainage procedure Effectiveness Emotional Employee Strikes Evaluation FDA approved Family Family suidae Feasibility Studies Force of Gravity Goals Gold Head Head-Down Tilt Heart Heart Arrest Heart Atrium Hospitals Hour Human Human Resources Interruption Intervention Studies Intracranial Hypertension Intracranial Pressure Laboratories Lower Extremity Lung Malignant Neoplasms Manikins Manuals Measurement Measures Medical Methods Microspheres Minnesota Modeling Modification Nervous System Physiology Neurologic Neurological outcome Organ Outcome Oxygen saturation measurement Patients Percussion Perfusion Phase Physiological Physiology Positioning Attribute Process Pupil light reflex Reproducibility Research Respiration Resuscitation Safety Sepsis Series Shock Small Business Innovation Research Grant Stroke Sudden Death Supine Position Survival Rate System Techniques Technology Testing Time Trauma Traumatic Brain Injury United States National Institutes of Health Universities Venous Veterinarians Work base blood pump c new clinically significant commercialization coronary perfusion design electric impedance ergonomics hemodynamics improved innovation light weight novel novel strategies pre-clinical preclinical safety pressure programs prototype psychologic research clinical testing sound

项目摘要

Abstract Nearly 90% of patients who suffer an out-of-hospital cardiac arrest (CA) die. This leading cause of unexpected and sudden death in the US results in an enormous emotional, psychological and financial burden to hundreds of thousands of families and communities across America annually. Relative to the many potentially lethal disease states such as cancer, stroke, sepsis, and trauma, CA survival rates have barely improved since 1960 when manual standard (S) was first described. Over the past 25 years, the applicants have discovered and developed new approaches, techniques and devices to increase cerebral and coronary blood flow and improve neurologically-sound survival after CA. With prior NIH SBIR support they developed the impedance threshold device (ITD), performed animal and clinical trials, and ultimately obtained FDA approval for manual active compression decompression (ACD) plus ITD, the first device ever approved by the FDA to increase the likelihood of survival after CA. Despite this progress, further innovation is needed to substantively improve successful outcomes for more Americans. This application is focused on a new discovery that elevation of the head and thorax during ACD + ITD CPR results in a striking decrease in intracranial pressures and an increase in cerebral and coronary perfusion pressures. These findings, due to the effects of gravity when the head and heart are elevated, have the potential to significantly further enhance cerebral and coronary blood flow and improve overall survivability. The proposed research in an animal model of cardiac arrest is focused on demonstrating proof-of-concept that a new head up CPR device, when used in combination with ACD + ITD CPR, is able to significantly improve blood flow to the heart and brain safely and effectively increase 48-hour survival in an animal model of prolonged CA. We further propose to assess the ergonomics and human factors associated with a light-weight human prototypic head up CPR device in manikins and human cadavers with help of professional firefighters. This novel and approach could increase neurologically-favorable survival rates for >10,000 more Americans annually due to greater blood flow and lower intracranial pressure afforded by gravity-enhanced head up CPR.

抽象的遭受院外心脏骤停（CA）的患者中，近90％死亡。这个主要原因美国意外的和突然的死亡导致了巨大的情感，心理和财务每年在美国各地成千上万的家庭和社区负担。相对于许多潜在的致命疾病状态，例如癌症，中风，败血症和创伤，CA存活率自1960年首次描述手动标准以来，几乎没有改善。过去25 多年来，申请人发现并开发了新的方法，技术和设备增加大脑和冠状动脉血流，并改善大约之后的神经学上的存活率。和在NIH SBIR之前，他们开发了阻抗阈值设备（ITD），执行动物和临床试验，并最终获得了手动主动压缩减压的FDA批准（ACD）加上ITD，这是FDA有史以来第一个增加生存可能性之后的设备大约尽管取得了这些进展，但仍需要进一步的创新来实质性地改善成功的成果对于更多的美国人。该应用程序的重点是新发现，即头部的抬高和 ACD + ITD CPR期间的胸部导致颅内压力的显着降低和增加大脑和冠状动脉灌注压力。这些发现，由于重力的影响心脏升高，有可能进一步增强大脑和冠状动脉血液流动并提高整体生存能力。心脏骤停模型中的拟议研究是专注于证明概念概念，即组合使用新的CPR设备使用ACD + ITD CPR，能够显着改善流向心脏和大脑的血液，并在长时间的动物模型中，有效地增加了48小时的生存。我们进一步建议评估与轻巧的人类原型头部相关的人体工程学和人为因素在专业消防员的帮助下，在Manikins和人类尸体中的CPR设备。这本小说和方法可能会增加> 10,000的美国人的神经学上有利的生存率由于血液流动更大和由重力增强的头部在CPR上提供的较高的颅内压。

项目成果

期刊论文数量（4）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Controlled sequential elevation of the head and thorax combined with active compression decompression cardiopulmonary resuscitation and an impedance threshold device improves neurological survival in a porcine model of cardiac arrest.

头部和胸部的受控顺序抬高结合主动加压减压心肺复苏和阻抗阈值装置可改善心脏骤停猪模型的神经存活率。

DOI：
10.1016/j.resuscitation.2020.09.030
发表时间：
2021-01
期刊：
Resuscitation
影响因子：
6.5
作者：
Moore JC;Salverda B;Rojas-Salvador C;Lick M;Debaty G;G Lurie K
通讯作者：
G Lurie K

Effect of controlled sequential elevation timing of the head and thorax during cardiopulmonary resuscitation on cerebral perfusion pressures in a porcine model of cardiac arrest.

DOI：
10.1016/j.resuscitation.2019.12.011
发表时间：
2020-04
期刊：
RESUSCITATION
影响因子：
6.5
作者：
Rojas-Salvador, Carolina;Moore, Johanna C.;Salverda, Bayert;Lick, Michael;Debaty, Guillaume;Lurie, Keith G.
通讯作者：
Lurie, Keith G.

Controlled progressive elevation rather than an optimal angle maximizes cerebral perfusion pressure during head up CPR in a swine model of cardiac arrest.