Developing a Treatment Planning System for Next Generation Rotating-Shield Brachytherapy

开发下一代旋转屏蔽近距离放射治疗的治疗计划系统

• 批准号: 9316911
• 负责人: Xiaodong Wu
• 金额: $ 2.6万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-10 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9316911
• 关键词: Algorithms; Applications Grants; Attenuated; Automobile Driving; Biomedical Engineering; Brachytherapy; Breast; Cancer Patient; Catheters; Cervix Uteri; Clinic; Clinical; Clinical Trials; Collaborations; Combinatorial Optimization; Complex; Complication; Computer software; Decision Making; Development; Discipline; Dose; Electronics; Endometrium; Epidural Anesthesia; Foundations; General Anesthesia; Goals; Health; High-Dose Rate Brachytherapy; Image; Intensity-Modulated Radiotherapy; Interdisciplinary Study; Magnetic Resonance Imaging; Malignant Neoplasms; Malignant neoplasm of cervix uteri; Malignant neoplasm of prostate; Maps; Medical Computer Science; Methods; Modality; Motion; Nature; Organ; Patients; Performance; Phase; Physics; Planning Techniques; Positron-Emission Tomography; Prostate; Radiation; Radiation Oncology; Radiation therapy; Rectum; Research; Research Personnel; Research Project Grants; Risk; Source; Spinal Anesthesia; Structure; System; Techniques; Technology; Time; Toxic effect; Treatment Effectiveness; Vagina; arm; base; cancer site; dosimetry; empowered; human subject; improved; innovation; innovative technologies; meetings; new technology; next generation; novel; tool; treatment planning; tumor

 DESCRIPTION (provided by applicant): Rotating shield brachytherapy (RSBT) is a novel form of high-dose-rate brachytherapy (HDR-BT) delivered through shielded, rotating, catheters, which provide unprecedented control over radiation dose distributions. RSBT is expected to provide superior sub-volume boosting and toxicity relative to any existing radiotherapy modality, resulting in a paradigm shift in HDR-BT for many cancer sites. Although RSBT was conceptualized more than ten years ago, its clinical implementation poses tremendous challenges, demanding fundamentally advanced innovative technologies. With recent development of radiation sources, an effective and efficient RSBT treatment planning system has become a limiting factor for clinical development of RSBT. To this end, this project will develop fundamentally novel technology and algorithms to break the formidable computational barriers to bring RSBT into clinic. We hypothesize that rotating shield brachytherapy, powered with advanced treatment planning techniques and software, will provide significant dosimetric improvements in tumor coverage and critical structure avoidance relative to conventional HDR-BT, with a clinically acceptable delivery time. We propose to: 1) Develop an efficient compressed sensing based RSBT inverse dose optimization method, enabling sparse intensity modulation and optimized homogeneity of dose distributions with smooth fluence maps in the resulting treatment plan. 2) Develop efficient shield sequencing methods to optimize the delivery of RSBT treatment plans, striving to achieve the best tradeoff between plan quality and treatment time, and to facilitate clinicians' decision making on selecting the best patient-specifi treatment plan. 3) Dosimetrically validate the RSBT treatment planning system retrospectively with clinical cases of cervical cancers and prostate cancers previously treated with HDR-BT. As a result, our project will pave the road to make RSBT clinically available, triggering a new era in brachytherapy delivery.

 描述（由适用提供）：旋转屏蔽近距离射术（RSBT）是通过屏蔽，旋转的导管提供的一种新型的高剂量速率近距离近距离疗法（HDR-BT），可提供对辐射剂量分布的前所未有的控制。相对于任何现有的放射疗法模式，RSBT有望提供较高的亚体积增强和毒性，从而导致许多癌症部位的HDR-BT范式变化。尽管RSBT在十多年前被概念化，但其临床实施构成了巨大的挑战，要求从根本上进行先进的创新技术。随着辐射源的最新发展，有效有效的RSBT治疗计划系统已成为RSBT临床发展的限制因素。为此，该项目将开发从根本上进行新颖的技术和算法，以打破强大的计算障碍，以将RSBT带入诊所。我们假设以先进的治疗计划技术和软件为动力的旋转屏蔽近距离放射治疗将在临床上可接受的交付时间上提供显着的肿瘤覆盖范围和临界结构避免的剂量法改善。我们建议：1）开发一个有效的基于压缩感应的RSBT反剂量优化方法，从而实现稀疏强度调节和在生成的治疗计划中具有光滑的剂量分布的优化剂量分布的均匀性。 2）开发有效的屏蔽测序方法，以优化RSBT治疗计划的交付，努力在计划质量和治疗时间之间取得最佳折衷，并促进临床医生在选择最佳患者特异性治疗计划方面的决策。 3）剂量法对RSBT治疗计划系统进行了回顾性，并使用先前用HDR-BT治疗的宫颈癌和前列腺癌的临床病例进行回顾性验证。结果，我们的项目将铺平道路，使RSBT在临床上可用，从而引发了一个新时代 近距离放射治疗。